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microdialysis

  • Open Access
    Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis
    Pharmacology
    Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis

    The nitroimidazole DNDI-0690 is a clinical drug candidate for visceral leishmaniasis (VL) that also shows potent in vitro and in vivo activity against cutaneous leishmaniasis (CL). To support further development of this compound into a patient-friendly oral or topical formulation for the treatment of CL, we investigated the free drug exposure at the dermal site of infection and subsequent elimination of the causative...

    Gert-Jan Wijnant, Simon L. Croft, Raul de la Flor, Mo Alavijeh, Vanessa Yardley, Stéphanie Braillard, Charles Mowbray, Katrien Van Bocxlaer
  • Microdialysis Study of Aztreonam-Avibactam Distribution in Peritoneal Fluid and Muscle of Rats with or without Experimental Peritonitis
    Pharmacology
    Microdialysis Study of Aztreonam-Avibactam Distribution in Peritoneal Fluid and Muscle of Rats with or without Experimental Peritonitis

    The purpose of this study was to investigate aztreonam (ATM) and avibactam (AVI) distribution in intraperitoneal fluid and muscle interstitial fluid by microdialysis in rats, with or without peritonitis, and to compare the unbound concentrations in tissue with the unbound concentrations in blood. Microdialysis probes were inserted into the jugular veins, hind leg muscles, and peritoneal cavities of control rats (n = 5) and rats...

    Alexia Chauzy, Isabelle Lamarche, Christophe Adier, William Couet, Sandrine Marchand
  • Clinical Therapeutics
    Population Pharmacokinetics of Meropenem in Plasma and Subcutis from Patients on Extracorporeal Membrane Oxygenation Treatment
    Pelle Hanberg, Kristina Öbrink-Hansen, Anders Thorsted, Mats Bue, Mikkel Tøttrup, Lena E. Friberg, Tore Forsingdal Hardlei, Kjeld Søballe, Jakob Gjedsted
  • Clinical Therapeutics
    Concentrations of Cefuroxime in Brain Tissue of Neurointensive Care Patients
    A. Hosmann, L. C. Ritscher, H. Burgmann, Z. Oesterreicher, W. Jäger, S. Poschner, E. Knosp, A. Reinprecht, A. Gruber, M. Zeitlinger
  • Pharmacology
    Comparative Assessment of Tedizolid Pharmacokinetics and Tissue Penetration between Diabetic Patients with Wound Infections and Healthy Volunteers via In Vivo Microdialysis
    Sean M. Stainton, Marguerite L. Monogue, Arlinda Baummer-Carr, Ashley K. Shepard, James F. Nugent, Joseph L. Kuti, David P. Nicolau
  • Clinical Therapeutics
    Pharmacokinetics and Tissue Penetration of Ceftolozane-Tazobactam in Diabetic Patients with Lower Limb Infections and Healthy Adult Volunteers
    Marguerite L. Monogue, Sean M. Stainton, Arlinda Baummer-Carr, Ashley K. Shepard, James F. Nugent, Joseph L. Kuti, David P. Nicolau
  • Susceptibility
    Pharmacokinetics of Cefuroxime in Synovial Fluid
    R. Schwameis, S. Syré, D. Marhofer, A. Appelt, D. Burau, K. Sarahrudi, C. Kloft, M. Zeitlinger
  • Pharmacology
    Population Pharmacokinetic Modeling as a Tool To Characterize the Decrease in Ciprofloxacin Free Interstitial Levels Caused by Pseudomonas aeruginosa Biofilm Lung Infection in Wistar Rats
    Bruna G. S. Torres, Victória E. Helfer, Priscila M. Bernardes, Alexandre José Macedo, Elisabet I. Nielsen, Lena E. Friberg, Teresa Dalla Costa
  • Pharmacology
    Influence of Experimental Cryptococcal Meningitis in Wistar Rats on Voriconazole Brain Penetration Assessed by Microdialysis
    Izabel Almeida Alves, Keli Jaqueline Staudt, Carolina de Miranda Silva, Graziela de Araujo Lock, Teresa Dalla Costa, Bibiana Verlindo de Araujo
  • Pharmacology
    Lung Tissue Concentrations of Pyrazinamide among Patients with Drug-Resistant Pulmonary Tuberculosis
    Russell R. Kempker, M. Tobias Heinrichs, Ketino Nikolaishvili, Irina Sabulua, Nino Bablishvili, Shota Gogishvili, Zaza Avaliani, Nestani Tukvadze, Brent Little, Adam Bernheim, Timothy D. Read, Jeannette Guarner, Hartmut Derendorf, Charles A. Peloquin, Henry M. Blumberg, Sergo Vashakidze

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