MmpL3
Mechanisms of Action: Physiological EffectsSynergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessusNew drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus. Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus. We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and...
![1<em>H</em>-Benzo[<em>d</em>]Imidazole Derivatives Affect MmpL3 in <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span>](https://aac.asm.org/sites/default/files/styles/thumbnail/public/externals/0284aba2d9c90d343ecad3753723bc65.jpg?itok=g4CsECuU)
Mechanisms of Action: Physiological Effects1H-Benzo[d]Imidazole Derivatives Affect MmpL3 in Mycobacterium tuberculosis1H-benzo[d]imidazole derivatives exhibit antitubercular activity in vitro at a nanomolar range of concentrations and are not toxic to human cells, but their mode of action remains unknown. Here, we showed that these compounds are active against intracellular Mycobacterium tuberculosis.
Chemistry; BiosynthesisIndole-2-Carboxamides Are Active against Mycobacterium abscessus in a Mouse Model of Acute InfectionNontuberculous mycobacteria (NTM) pathogens particularly infect patients with structural lung disorders. We previously reported novel indole-2-carboxamides (ICs) that are active against a wide panel of NTM pathogens.
- Experimental TherapeuticsHC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid Transporter