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mortality

  • Open Access
    A Retrospective Controlled Cohort Study of the Impact of Glucocorticoid Treatment in SARS-CoV-2 Infection Mortality
    Editor's Pick Antiviral Agents
    A Retrospective Controlled Cohort Study of the Impact of Glucocorticoid Treatment in SARS-CoV-2 Infection Mortality

    Evidence to support the use of steroids in coronavirus disease 2019 (COVID-19) pneumonia is lacking. We aim to determine the impact of steroid use for COVID-19 pneumonia on hospital mortality. We performed a single-center retrospective cohort study in a university hospital in Madrid, Spain, during March of 2020. To determine the role of steroids in in-hospital mortality, patients admitted with severe acute respiratory syndrome...

    Ana Fernández-Cruz, Belén Ruiz-Antorán, Ana Muñoz-Gómez, Aránzazu Sancho-López, Patricia Mills-Sánchez, Gustavo Adolfo Centeno-Soto, Silvia Blanco-Alonso, Laura Javaloyes-Garachana, Amy Galán-Gómez, Ángela Valencia-Alijo, Javier Gómez-Irusta, Concepción Payares-Herrera, Ignacio Morrás-Torre, Enrique Sánchez-Chica, Laura Delgado-Téllez-de-Cepeda, Alejandro Callejas-Díaz, Antonio Ramos-Martínez, Elena Múñez-Rubio, Cristina Avendaño-Solá
    and on behalf of the Puerta de Hierro COVID-19 Study Group
  • Free
    A Randomized Clinical Trial of the Efficacy and Safety of Interferon β-1a in Treatment of Severe COVID-19
    Editor's Pick Antiviral Agents
    A Randomized Clinical Trial of the Efficacy and Safety of Interferon β-1a in Treatment of Severe COVID-19

    To the best of our knowledge, there is no published study on the use of interferon β-1a (IFN β-1a) in the treatment of severe COVID-19. In this randomized clinical trial, the efficacy and safety of IFN β-1a were evaluated in patients with severe COVID-19. Forty-two patients in the interferon group received IFN β-1a in addition to the national protocol medications (hydroxychloroquine plus lopinavir-ritonavir or atazanavir-ritonavir)....

    Effat Davoudi-Monfared, Hamid Rahmani, Hossein Khalili, Mahboubeh Hajiabdolbaghi, Mohamadreza Salehi, Ladan Abbasian, Hossein Kazemzadeh, Mir Saeed Yekaninejad
  • Extended-Spectrum-β-Lactamase- and Plasmid AmpC-Producing <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Causing Community-Onset Bloodstream Infection: Association of Bacterial Clones and Virulence Genes with Septic Shock, Source of Infection, and Recurrence
    Epidemiology and Surveillance
    Extended-Spectrum-β-Lactamase- and Plasmid AmpC-Producing Escherichia coli Causing Community-Onset Bloodstream Infection: Association of Bacterial Clones and Virulence Genes with Septic Shock, Source of Infection, and Recurrence

    Invasive infections due to extended-spectrum-β-lactamase- and pAmpC-producing Escherichia coli (ESBL/pAmpC-EC) are an important cause of morbidity, often caused by the high-risk clone sequence type (ST131) and isolates classified as extraintestinal pathogenic E. coli (ExPEC). The relative influence...

    Inga Fröding, Badrul Hasan, Isak Sylvin, Maarten Coorens, Pontus Nauclér, Christian G. Giske
  • Impact of KPC Production and High-Level Meropenem Resistance on All-Cause Mortality of Ventilator-Associated Pneumonia in Association with <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span>
    Clinical Therapeutics
    Impact of KPC Production and High-Level Meropenem Resistance on All-Cause Mortality of Ventilator-Associated Pneumonia in Association with Klebsiella pneumoniae

    Carbapenemase-producing Enterobacterales and specifically Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) are rapidly spreading worldwide. The prognosis of ventilator-associated pneumonia (VAP) caused by KPC-Kp is not well known. Our study tries to assess...

    Francisco Rivera-Espinar, Isabel Machuca, Rocio Tejero, Jorge Rodríguez, Ana Mula, Eduardo Marfil, Ángela Cano, Belén Gutiérrez-Gutiérrez, Marina Rodríguez, Juan Carlos Pozo, Carmen De la Fuente, Jesús Rodriguez-Baño, Luis Martínez-Martínez, Rafael León, Julian Torre-Cisneros
  • Relationship between Vancomycin MIC and Virulence Gene Expression in Clonal Complexes of Methicillin-Susceptible <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Strains Isolated from Left-Sided Endocarditis
    Clinical Therapeutics
    Relationship between Vancomycin MIC and Virulence Gene Expression in Clonal Complexes of Methicillin-Susceptible Staphylococcus aureus Strains Isolated from Left-Sided Endocarditis

    Higher vancomycin MICs have been associated with more complicated courses and higher mortality rates in patients with Staphylococcus aureus bacteremia and infective endocarditis (IE).

    Juan M. Pericàs, Carlos Cervera, Cristina Garcia-de-la-Mària, Batu K. Sharma-Kuinkel, Rachelle Gonzales, Asunción Moreno, Manel Almela, Carlos Falces, Eduard Quintana, David Fuster, Francesc Marco, Arnold S. Bayer, Vance G. Fowler, José M. Miró
    and the Hospital Clinic Endocarditis Study Group
  • Predictors of Mortality in Bloodstream Infections Caused by <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> and Impact of Antimicrobial Resistance and Bacterial Virulence
    Clinical Therapeutics
    Predictors of Mortality in Bloodstream Infections Caused by Pseudomonas aeruginosa and Impact of Antimicrobial Resistance and Bacterial Virulence

    Whether multidrug resistance (MDR) is associated with mortality in patients with Pseudomonas aeruginosa bloodstream infections (BSI) remains controversial. Here, we explored the prognostic factors of P. aeruginosa BSI with emphasis on antimicrobial resistance and virulence. All...

    Raúl Recio, Mikel Mancheño, Esther Viedma, Jennifer Villa, María Ángeles Orellana, Jaime Lora-Tamayo, Fernando Chaves
  • Open Access
    Clinical Data on Daptomycin plus Ceftaroline versus Standard of Care Monotherapy in the Treatment of Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Bacteremia
    Clinical Therapeutics
    Clinical Data on Daptomycin plus Ceftaroline versus Standard of Care Monotherapy in the Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia

    Vancomycin (VAN) and daptomycin (DAP) are approved as a monotherapy for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. A regimen of daptomycin plus ceftaroline (DAP+CPT) has shown promise in published case series of MRSA salvage therapy, but no comparative data exist to compare up-front DAP+CPT head-to-head therapy versus standard monotherapy as an...

    Matthew Geriak, Fadi Haddad, Khulood Rizvi, Warren Rose, Ravina Kullar, Kerry LaPlante, Marie Yu, Logan Vasina, Krista Ouellette, Marcus Zervos, Victor Nizet, George Sakoulas
  • Antibiotic-Induced Dysbiosis Predicts Mortality in an Animal Model of <span class="named-content genus-species" id="named-content-1">Clostridium difficile</span> Infection
    Mechanisms of Action: Physiological Effects
    Antibiotic-Induced Dysbiosis Predicts Mortality in an Animal Model of Clostridium difficile Infection

    Antibiotic disruption of the intestinal microbiota favors colonization by Clostridium difficile. Using a charcoal-based adsorbent to decrease intestinal antibiotic concentrations, we studied the relationship between antibiotic concentrations in feces and the intensity of dysbiosis and quantified the link between this intensity and mortality.

    Charles Burdet, Sakina Sayah-Jeanne, Thu Thuy Nguyen, Perrine Hugon, Frédérique Sablier-Gallis, Nathalie Saint-Lu, Tanguy Corbel, Stéphanie Ferreira, Mark Pulse, William Weiss, Antoine Andremont, France Mentré, Jean de Gunzburg
  • Clinical Therapeutics
    Systematic Review and Meta-analysis of the Efficacy of Short-Course Antibiotic Treatments for Community-Acquired Pneumonia in Adults

    The duration of therapy for community-acquired pneumonia (CAP) remains undefined. We sought to investigate whether short-course antibiotic treatment for CAP is associated with favorable clinical outcomes in adult patients.

    Giannoula S. Tansarli, Eleftherios Mylonakis
  • Clinical Therapeutics
    Role of Lock Therapy for Long-Term Catheter-Related Infections by Multidrug-Resistant Bacteria

    The management of long-term central venous catheter (LTCVC) infections by multidrug-resistant (MDR) bacteria in cancer patient is a challenge. The objectives of this study were to analyze outcomes in cancer patients with LTCVC-associated infection, identify risks for unfavorable outcomes, and determine the impact of MDR bacteria and antibiotic lock therapy (ALT) in managing such infections.

    Maristela P. Freire, Ligia C. Pierrotti, Antonio E. Zerati, Luciana Benites, Joaquim Mauricio da Motta-Leal Filho, Karim Y. Ibrahim, Pedro H. Araujo, Edson Abdala

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