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MRSA

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    Case Commentary: Imipenem/Cilastatin and Fosfomycin for Refractory Methicillin-Resistant <em>Staphylococcus aureus</em> Infection: a Novel Combination Therapy
    Editor's Pick Challenging Clinical Case in Antimicrobial Resistance
    Case Commentary: Imipenem/Cilastatin and Fosfomycin for Refractory Methicillin-Resistant Staphylococcus aureus Infection: a Novel Combination Therapy

    Given that it is unlikely that randomized clinical trials will yield answers for treating the most challenging bacteremic infections caused by methicillin-resistant Staphylococcus aureus, clinicians, microbiologists, and pharmacists will have to cooperate to discover novel ways to select successful individualized antimicrobial therapy for these patients. An example of...

    George Sakoulas
  • Efficacy of Telavancin in Comparison to Linezolid in a Porcine Model of Severe Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Pneumonia
    Experimental Therapeutics
    Efficacy of Telavancin in Comparison to Linezolid in a Porcine Model of Severe Methicillin-Resistant Staphylococcus aureus Pneumonia

    Current guidelines recommend vancomycin and linezolid as first-line agents against methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. Telavancin is a potential new therapeutic alternative, specifically in monomicrobial MRSA pneumonia. This study compared the efficacies of telavancin versus linezolid in a porcine model of severe MRSA pneumonia. In...

    D. Battaglini, A. Motos, G. Li Bassi, H. Yang, F. Pagliara, M. Yang, E. Aguilera Xiol, A. Meli, J. Bobi, G. Frigola, T. Senussi, F. Idone, C. Travierso, C. Chiurazzi, L. Fernandez-Barat, M. Rigol, J. Ramirez, P. Pelosi, D. Chiumello, M. Antonelli, D. P. Nicolau, J. Bringue, A. Artigas, L. Guerrero, D. Soy, A. Torres
  • <em>De Novo</em> Resistance to Arg<sub>10</sub>-Teixobactin Occurs Slowly and Is Costly
    Mechanisms of Resistance
    De Novo Resistance to Arg10-Teixobactin Occurs Slowly and Is Costly

    Bacterial pathogens are rapidly evolving resistance to all clinically available antibiotics. One part of the solution to this complex issue is to better understand the resistance mechanisms to new and existing antibiotics. Here, we focus on two antibiotics. Teixobactin is a recently discovered promising antibiotic that is claimed to “kill pathogens without detectable resistance” (L. L. Ling, T. Schneider, A. J. Peoples, A. L. Spoering,...

    Daniel G. Lloyd, Benjamin J. Schofield, Matthew R. Goddard, Edward J. Taylor
  • <em>In Vivo</em> Pharmacodynamic Target Assessment of Antofloxacin against <span class="named-content genus-species" id="named-content-1">Streptococcus pneumoniae</span> and <span class="named-content genus-species" id="named-content-2">Staphylococcus aureus</span> in a Neutropenic Murine Pneumonia Model
    Pharmacology
    In Vivo Pharmacodynamic Target Assessment of Antofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a Neutropenic Murine Pneumonia Model

    We determined in vivo efficacy and target PK/PD exposures of antofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in the murine pneumonia model. The mean plasma free drug area under the concentration-time curve/MIC (fAUC/MIC) targets associated with stasis and 1-...

    Yu-Feng Zhou, Ping Liu, Shu-He Dai, Jian Sun, Ya-Hong Liu, Xiao-Ping Liao
  • Open Access
    Successful Development of Bacteriocins into Therapeutic Formulation for Treatment of MRSA Skin Infection in a Murine Model
    Experimental Therapeutics
    Successful Development of Bacteriocins into Therapeutic Formulation for Treatment of MRSA Skin Infection in a Murine Model

    The emergence of antibiotic-resistant pathogens has caused a serious worldwide problem in infection treatment in recent years. One of the pathogens is methicillin-resistant Staphylococcus aureus (MRSA), which is a major cause of skin and soft tissue infections. Alternative strategies and novel sources of antimicrobials to solve antibiotic resistance problems are...

    Kirill V. Ovchinnikov, Christian Kranjec, Tage Thorstensen, Harald Carlsen, Dzung B. Diep
  • <em>In Vitro</em> Activity and Potency of the Novel Oxazolidinone Contezolid (MRX-I) Tested against Gram-Positive Clinical Isolates from the United States and Europe
    Epidemiology and Surveillance
    In Vitro Activity and Potency of the Novel Oxazolidinone Contezolid (MRX-I) Tested against Gram-Positive Clinical Isolates from the United States and Europe

    Contezolid, a new oxazolidinone antibacterial agent currently in development for the treatment of skin and skin structure infections, was susceptibility tested against Gram-positive clinical isolates (n = 1,211). Contezolid demonstrated potent activity against Staphylococcus aureus (MIC50/90, 0.5/1 mg/liter), coagulase-negative Staphylococcus...

    Cecilia G. Carvalhaes, Leonard R. Duncan, Wen Wang, Helio S. Sader
  • Effect of the Lysin Exebacase on Cardiac Vegetation Progression in a Rabbit Model of Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Endocarditis as Determined by Echocardiography
    Pharmacology
    Effect of the Lysin Exebacase on Cardiac Vegetation Progression in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Endocarditis as Determined by Echocardiography

    Methicillin-resistant Staphylococcus aureus (MRSA) poses significant therapeutic challenges related to its frequency in clinical infections, innate virulence properties, and propensity for multiantibiotic resistance. MRSA is among the most common causes of endovascular infections, including infective endocarditis (IE). Our objective was to employ transthoracic...

    Sonia U. Shah, Yan Q. Xiong, Wessam Abdelhady, James Iwaz, Youngju Pak, Raymond Schuch, Cara Cassino, Dario Lehoux, Arnold S. Bayer
  • Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> (MRSA) Nasal Screening: Clinical Use for Excluding Diabetic Foot Infection with MRSA
    Letter to the Editor
    Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Screening: Clinical Use for Excluding Diabetic Foot Infection with MRSA
    Maroun M. Sfeir
  • Ceftobiprole Activity against Bacteria from Skin and Skin Structure Infections in the United States from 2016 through 2018
    Susceptibility
    Ceftobiprole Activity against Bacteria from Skin and Skin Structure Infections in the United States from 2016 through 2018

    Ceftobiprole medocaril is an advanced-generation cephalosporin prodrug that has qualified infectious disease product status granted by the US FDA and is currently being evaluated in phase 3 clinical trials in patients with acute bacterial skin and skin structure infections (ABSSSIs) and in patients with Staphylococcus aureus bacteremia. In this study, the activity of...

    Robert K. Flamm, Leonard R. Duncan, Kamal A. Hamed, Jennifer I. Smart, Rodrigo E. Mendes, Michael A. Pfaller
  • Antagonistic Effect of Colistin on Vancomycin Activity against Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> in <em>In Vitro</em> and <em>In Vivo</em> Studies
    Susceptibility
    Antagonistic Effect of Colistin on Vancomycin Activity against Methicillin-Resistant Staphylococcus aureus in In Vitro and In Vivo Studies

    As concerns arise that the vancomycin MIC of methicillin-resistant Staphylococcus aureus (MRSA) could be increased by concurrent colistin administration, we evaluated the effect of colistin on vancomycin efficacy against MRSA via in vitro and in vivo studies. Among MRSA blood isolates collected in a tertiary-care hospital, we selected representative...

    Sungim Choi, Song Mi Moon, Su-Jin Park, Seung Cheol Lee, Kyung Hwa Jung, Heung-sup Sung, Mi-Na Kim, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jin-Yong Jeong, Jun Hee Woo, Yang Soo Kim, Yong Pil Chong

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