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mucormycosis

  • <em>In Vitro</em> Evaluation of Radiolabeled Amphotericin B for Molecular Imaging of Mold Infections
    Chemistry; Biosynthesis
    In Vitro Evaluation of Radiolabeled Amphotericin B for Molecular Imaging of Mold Infections

    Invasive pulmonary aspergillosis and mucormycosis are life-threatening complications in immunocompromised patients. A rapid diagnosis followed by early antifungal treatment is essential for patient survival. Given the limited spectrum of biomarkers for invasive mold infections, recent studies have proposed the use of radiolabeled siderophores or antibodies as molecular probes to increase the specificity of radiological findings by...

    Lukas Page, Andrew J. Ullmann, Fabian Schadt, Sebastian Wurster, Samuel Samnick
  • Open Access
    Fosmanogepix (APX001) Is Effective in the Treatment of Pulmonary Murine Mucormycosis Due to <span class="named-content genus-species" id="named-content-1">Rhizopus arrhizus</span>
    Experimental Therapeutics
    Fosmanogepix (APX001) Is Effective in the Treatment of Pulmonary Murine Mucormycosis Due to Rhizopus arrhizus

    Mucormycosis is a life-threatening infection with high mortality that occurs predominantly in immunocompromised patients. Manogepix (MGX) is a novel antifungal that targets Gwt1, a protein involved in an early step in the conserved glycosylphosphotidyl inositol (GPI) posttranslational modification pathway of surface proteins in eukaryotic cells. Inhibition of fungal inositol acylation by MGX results in pleiotropic effects, including...

    Teclegiorgis Gebremariam, Sondus Alkhazraji, Abdullah Alqarihi, Nathan P. Wiederhold, Karen Joy Shaw, Thomas F. Patterson, Scott G. Filler, Ashraf S. Ibrahim
  • Therapeutic Challenges of Non-<em>Aspergillus</em> Invasive Mold Infections in Immunosuppressed Patients
    Editor's Pick Minireview
    Therapeutic Challenges of Non-Aspergillus Invasive Mold Infections in Immunosuppressed Patients

    While Aspergillus spp. remain the major cause of invasive mold infections in hematologic cancer patients and transplant recipients, other opportunistic molds, such as Mucorales, Fusarium, and Scedosporium spp. are increasingly encountered in an expanding population of patients with severe and prolonged immunosuppression. High potential for tissue invasion and dissemination, resistance to multiple...

    Frederic Lamoth, Dimitrios P. Kontoyiannis
  • <span class="named-content genus-species" id="named-content-1">Lichtheimia corymbifera</span> Colonization Leading to Pulmonary Infection Can Be Prevented with Liposomal Amphotericin B in a New Murine Model
    Experimental Therapeutics
    Lichtheimia corymbifera Colonization Leading to Pulmonary Infection Can Be Prevented with Liposomal Amphotericin B in a New Murine Model

    The incidence of pulmonary mucormycosis is constantly increasing, especially in hematological patients staying in high-efficiency particulate air-filtered rooms. Pulmonary inhalation of spores may occur outside the hospital, leading to invasive disease once patients received chemotherapies.

    Thomas Brunet, Kévin Brunet, Grégory Jouvion, Estelle Cateau, Sandrine Marchand, Blandine Rammaert
  • Immunosuppressed Adult Zebrafish Model of Mucormycosis
    Letter to the Editor
    Immunosuppressed Adult Zebrafish Model of Mucormycosis
    A. M. Tatara, S. Wurster, C. R. Lockworth, N. D. Albert, T. J. Walsh, A. G. Mikos, G. T. Eisenhoffer, D. P. Kontoyiannis
  • Letter to the Editor
    In Situ Validation of the Endothelial Cell Receptor GRP78 in a Case of Rhinocerebral Mucormycosis
    Evgenii Shumilov, Ulrike Bacher, Christina Perske, Alexander Mohr, Helmut Eiffert, Justin Hasenkamp, Lorenz Trümper, Gerald G. Wulf, Philipp Ströbel, Ashraf S. Ibrahim, Vivek Venkataramani
  • Experimental Therapeutics
    Prophylactic Treatment with VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection
    Teclegiorgis Gebremariam, Sondus Alkhazraji, Lin Lin, Nathan P. Wiederhold, Edward P. Garvey, William J. Hoekstra, Robert J. Schotzinger, Thomas F. Patterson, Scott G. Filler, Ashraf S. Ibrahim
  • Open Access
    Pharmacology
    Impact of Mucositis on Absorption and Systemic Drug Exposure of Isavuconazole
    Laura L. Kovanda, Francisco M. Marty, Johan Maertens, Amit V. Desai, Christopher Lademacher, Marc Engelhardt, Qiaoyang Lu, William W. Hope
  • Experimental Therapeutics
    Prophylaxis with Isavuconazole or Posaconazole Protects Immunosuppressed Mice from Pulmonary Mucormycosis
    Teclegiorgis Gebremariam, Sondus Alkhazraji, Clara Baldin, Laura Kovanda, Nathan P. Wiederhold, Ashraf S. Ibrahim
  • Experimental Therapeutics
    In Vitro and In Vivo Antifungal Susceptibilities of the Mucoralean Fungus Cunninghamella
    F. Javier Pastor, Mery Ruíz-Cendoya, Isabel Pujol, Emilio Mayayo, Deanna A. Sutton, Josep Guarro

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