mycobacteria
Editor's Pick Mechanisms of Action: Physiological EffectsUtilization of CRISPR Interference To Validate MmpL3 as a Drug Target in Mycobacterium tuberculosisThere is an urgent need for novel therapeutics to treat Mycobacterium tuberculosis infections. Genetic strategies for validating novel targets are available, yet their time-consuming nature limits their utility. Here, using MmpL3 as a model target, we report on the application of mycobacterial CRISPR interference for the rapid validation of target essentiality and...
SusceptibilityA Rapid Unraveling of the Activity and Antibiotic Susceptibility of MycobacteriaThe development of antibiotic-resistant bacteria is a worldwide health-related emergency that calls for new tools to study the bacterial metabolism and to obtain fast diagnoses. Indeed, the conventional analysis time scale is too long and affects our ability to fight infections.
Mechanisms of ResistanceIn Vitro Activity of PBTZ169 against Multiple Mycobacterium SpeciesIn this study, we demonstrate that PBTZ169 exhibits significant differences in in vitro activity against multiple Mycobacterium species. The amino acid polymorphism at codon 387 of decaprenylphosphoryl-beta-d-ribose oxidase (DprE1) can be used as a surrogate marker for in vitro susceptibility to PBTZ169 in mycobacteria.
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Letter to the EditorGrowing Knowledge about Mycobacterium simiae from Two Recent Studies- Mechanisms of Action: Physiological EffectsAccelerating Early Antituberculosis Drug Discovery by Creating Mycobacterial Indicator Strains That Predict Mode of Action
- Mechanisms of ResistanceImidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels
- Mechanisms of ResistanceIn Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis
- Experimental TherapeuticsSynthetic (p)ppGpp Analogue Is an Inhibitor of Stringent Response in Mycobacteria