Naegleria fowleri
Experimental TherapeuticsInhibition of Fatty Acid Oxidation as a New Target To Treat Primary Amoebic MeningoencephalitisPrimary amoebic meningoencephalitis (PAM) is a rapidly fatal infection caused by the free-living amoeba Naegleria fowleri. The amoeba migrates along the olfactory nerve to the brain, resulting in seizures, coma, and, eventually, death. Previous research has shown that Naegleria gruberi, a close...
Experimental TherapeuticsEnzymatic and Structural Characterization of the Naegleria fowleri GlucokinaseInfection with the free-living amoeba Naegleria fowleri leads to life-threatening primary amoebic meningoencephalitis. Efficacious treatment options for these infections are limited, and the mortality rate is very high (∼98%).