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Naegleria fowleri

  • Open Access
    Inhibition of Fatty Acid Oxidation as a New Target To Treat Primary Amoebic Meningoencephalitis
    Experimental Therapeutics
    Inhibition of Fatty Acid Oxidation as a New Target To Treat Primary Amoebic Meningoencephalitis

    Primary amoebic meningoencephalitis (PAM) is a rapidly fatal infection caused by the free-living amoeba Naegleria fowleri. The amoeba migrates along the olfactory nerve to the brain, resulting in seizures, coma, and, eventually, death. Previous research has shown that Naegleria gruberi, a close...

    Maarten J. Sarink, Aloysius G. M. Tielens, Annelies Verbon, Robert Sutak, Jaap J. van Hellemond
  • Enzymatic and Structural Characterization of the <em>Naegleria fowleri</em> Glucokinase
    Experimental Therapeutics
    Enzymatic and Structural Characterization of the Naegleria fowleri Glucokinase

    Infection with the free-living amoeba Naegleria fowleri leads to life-threatening primary amoebic meningoencephalitis. Efficacious treatment options for these infections are limited, and the mortality rate is very high (∼98%).

    Jillian E. Milanes, Jimmy Suryadi, Jan Abendroth, Wesley C. Van Voorhis, Kayleigh F. Barrett, David M. Dranow, Isabelle Q. Phan, Stephen L. Patrick, Soren D. Rozema, Muhammad M. Khalifa, Jennifer E. Golden, James C. Morris
  • Experimental Therapeutics
    Effect of Therapeutic Chemical Agents In Vitro and on Experimental Meningoencephalitis Due to Naegleria fowleri
    Jong-Hyun Kim, Suk-Yul Jung, Yang-Jin Lee, Kyoung-Ju Song, Daeho Kwon, Kyongmin Kim, Sun Park, Kyung-Il Im, Ho-Joon Shin
  • Experimental Therapeutics
    Synergistic Activities of Azithromycin and Amphotericin B against Naegleria fowleri In Vitro and in a Mouse Model of Primary Amebic Meningoencephalitis
    Shannon M. Soltow, George M. Brenner
  • Experimental Therapeutics
    Activities of Azithromycin and Amphotericin B against Naegleria fowleri In Vitro and in a Mouse Model of Primary Amebic Meningoencephalitis
    Shannon M. Goswick, George M. Brenner
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