NDM
Mechanisms of ResistanceKinetic Profile and Molecular Dynamic Studies Show that Y229W Substitution in an NDM-1/L209F Variant Restores the Hydrolytic Activity of the Enzyme toward Penicillins, Cephalosporins, and CarbapenemsThe New Delhi metallo-β-lactamase-1 (NDM-1) enzyme is the most common metallo-β-lactamase identified in many Gram-negative bacteria causing severe nosocomial infections. The aim of this study was to focus the attention on non-active-site residues L209 and Y229 of NDM-1 and to investigate their role in the catalytic mechanism.
Epidemiology and SurveillanceDiverse Vectors and Mechanisms Spread New Delhi Metallo-β-Lactamases among Carbapenem-Resistant Enterobacteriaceae in the Greater Boston AreaNew Delhi metallo-beta-lactamases (NDMs) are an uncommon but emerging cause of carbapenem resistance in the United States. Genomic factors promoting their domestic spread remain poorly characterized.
- Epidemiology and SurveillanceDiversity of Carbapenemase-Producing Escherichia coli Isolates in France in 2012-2013
With the dissemination of carbapenemase-producing Enterobacteriaceae (CPE) strains worldwide, carbapenem-hydrolyzing enzymes are increasingly reported among isolates of Escherichia coli, the first hospital and community-acquired opportunistic pathogen. Here, we have performed an epidemiological...
- Mechanisms of ResistanceCoexistence of Two blaNDM-5 Genes on an IncF Plasmid as Revealed by Nanopore Sequencing
- Epidemiology and SurveillanceComparison of Two Phenotypic Algorithms To Detect Carbapenemase-Producing Enterobacteriaceae
- Mechanisms of ResistanceEvaluation of the Carba NP Test in Oregon, 2013