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NDM-1

  • Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in <em>Acinetobacter</em> Species in Argentina
    Epidemiology and Surveillance
    Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in Acinetobacter Species in Argentina

    A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying blaNDM-1. Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii...

    Mark D. Adams, Fernando Pasteran, German M. Traglia, Jasmine Martinez, Fanny Huang, Christine Liu, Jennifer S. Fernandez, Carolina Lopez, Lisandro J. Gonzalez, Ezequiel Albornoz, Alejandra Corso, Alejandro J. Vila, Robert A. Bonomo, Maria Soledad Ramirez
  • Free
    Coinfections of Two Strains of NDM-1- and OXA-232-Coproducing <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> in a Kidney Transplant Patient
    Challenging Clinical Case in Antimicrobial Resistance
    Coinfections of Two Strains of NDM-1- and OXA-232-Coproducing Klebsiella pneumoniae in a Kidney Transplant Patient

    We report here a fatal case of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections in a renal transplant patient without a travel history in the prior year, from whom 2 genetically different CRKP (sequence type 14 [ST14] and ST2497) strains carrying the same plasmids and antimicrobial resistance genes, including blaNDM-1, bla...

    Deisy A. Contreras, Sean P. Fitzwater, Deepa D. Nanayakkara, Joanna Schaenman, Grace M. Aldrovandi, Omai B. Garner, Shangxin Yang
  • Synergistic Combinations and Repurposed Antibiotics Active against the Pandrug-Resistant <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> Nevada Strain
    Letter to the Editor
    Synergistic Combinations and Repurposed Antibiotics Active against the Pandrug-Resistant Klebsiella pneumoniae Nevada Strain
    Thea Brennan-Krohn, James E. Kirby
  • Impact of the Timing of Antibiotic Administration on Digestive Colonization with Carbapenemase-Producing <em>Enterobacteriaceae</em> in a Murine Model
    Experimental Therapeutics
    Impact of the Timing of Antibiotic Administration on Digestive Colonization with Carbapenemase-Producing Enterobacteriaceae in a Murine Model

    While antibiotic use is a risk factor of carbapenemase-producing Enterobacteriaceae (CPE) acquisition, the importance of timing of antibiotic administration relative to CPE exposure remains unclear. In a murine model of gut colonization by New Delhi metallo-beta-lactamase-1 (NDM-1)-producing Klebsiella...

    Rémi Le Guern, Teddy Grandjean, Marvin Bauduin, Martin Figeac, Guillaume Millot, Aurore Loquet, Karine Faure, Eric Kipnis, Rodrigue Dessein
  • Azidothymidine Produces Synergistic Activity in Combination with Colistin against Antibiotic-Resistant <em>Enterobacteriaceae</em>
    Experimental Therapeutics
    Azidothymidine Produces Synergistic Activity in Combination with Colistin against Antibiotic-Resistant Enterobacteriaceae

    Bacterial infections remain a leading killer worldwide, which is worsened by the continuous emergence of antibiotic resistance. In particular, antibiotic-resistant Enterobacteriaceae are prevalent and extremely difficult to treat.

    Yanmin Hu, Yingjun Liu, Anthony Coates
  • Identification and Characterization of IncA/C Conjugative, <em>bla</em><sub>NDM-1</sub>-Bearing Plasmid in <span class="named-content genus-species" id="named-content-1">Vibrio alginolyticus</span> of Food Origin
    Letter to the Editor
    Identification and Characterization of IncA/C Conjugative, blaNDM-1-Bearing Plasmid in Vibrio alginolyticus of Food Origin
    Zhiwei Zheng, Ruichao Li, Lianwei Ye, Edward Wai-chi Chan, Sheng Chen
  • Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1
    Mechanisms of Resistance
    Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1

    β-Lactam antibiotics are the mainstay for the treatment of bacterial infections. However, elevated resistance to these antibiotics mediated by metallo-β-lactamases (MBLs) has become a global concern.

    Hongmin Zhang, Guixing Ma, Yifan Zhu, Lingxiao Zeng, Ashfaq Ahmad, Changzhi Wang, Bo Pang, Huiyan Fang, Liqing Zhao, Quan Hao
  • Synergistic Activity of Colistin-Containing Combinations against Colistin-Resistant <span class="named-content genus-species" id="named-content-1">Enterobacteriaceae</span>
    Susceptibility
    Synergistic Activity of Colistin-Containing Combinations against Colistin-Resistant Enterobacteriaceae

    Resistance to colistin, a polypeptide drug used as an agent of last resort for the treatment of infections caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative bacteria, including carbapenem-resistant Enterobacteriaceae (CRE), severely limits treatment options and may even transform an XDR organism into one that is pan-resistant. We...

    Thea Brennan-Krohn, Alejandro Pironti, James E. Kirby
  • Coidentification of <em>mcr-4.3</em> and <em>bla</em><sub>NDM-1</sub> in a Clinical <span class="named-content genus-species" id="named-content-1">Enterobacter cloacae</span> Isolate from China
    Mechanisms of Resistance
    Coidentification of mcr-4.3 and blaNDM-1 in a Clinical Enterobacter cloacae Isolate from China

    We describe the first report of a clinical colistin-resistant ST84 Enterobacter cloacae isolate coharboring mcr-4.3 (previously named mcr-4.2) and blaNDM-1 from a patient in China. The blaNDM-1-harboring IncX3 plasmid and the novel mcr-4.3-harboring ColE plasmid were completely sequenced.

    ...
    Bhakti Chavda, Jingnan Lv, Mengyun Hou, Kalyan D. Chavda, Barry N. Kreiswirth, Youjun Feng, Liang Chen, Fangyou Yu
  • Mechanisms of Resistance
    Spread of Plasmid-Encoded NDM-1 and GES-5 Carbapenemases among Extensively Drug-Resistant and Pandrug-Resistant Clinical Enterobacteriaceae in Durban, South Africa
    Torunn Pedersen, John Osei Sekyere, Usha Govinden, Krishnee Moodley, Audun Sivertsen, Ørjan Samuelsen, Sabiha Yusuf Essack, Arnfinn Sundsfjord

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