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Neisseria gonorrhoeae

  • Open Access
    Atypical Mutation in <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> 23S rRNA Associated with High-Level Azithromycin Resistance
    Mechanisms of Resistance
    Atypical Mutation in Neisseria gonorrhoeae 23S rRNA Associated with High-Level Azithromycin Resistance

    A2059G mutation in the 23S rRNA gene is the only reported mechanism conferring high-level azithromycin resistance (HL-AZMR) in Neisseria gonorrhoeae. Through U.S. gonococcal antimicrobial resistance surveillance projects, we identified four HL-AZMR gonococcal isolates lacking this mutational genotype. Genetic analysis revealed an A2058G mutation of 23S rRNA alleles in...

    Cau D. Pham, Evelyn Nash, Hsi Liu, Matthew W. Schmerer, Samera Sharpe, Grace Woods, Brad Roland, Karen Schlanger, Sancta B. St. Cyr, Jonathan Carlson, Kevin Sellers, Aaron Olsen, Ruth Sanon, Henrietta Hardin, Olusegun O. Soge, Brian H. Raphael, Ellen N. Kersh
    and on behalf of the AR Lab Network Workgroup for GC
  • Open Access
    Sodium Tetraphenylborate Displays Selective Bactericidal Activity against <span class="named-content genus-species" id="named-content-1">Neisseria meningitidis</span> and <span class="named-content genus-species" id="named-content-2">N. gonorrhoeae</span> and Is Effective at Reducing Bacterial Infection Load
    Experimental Therapeutics
    Sodium Tetraphenylborate Displays Selective Bactericidal Activity against Neisseria meningitidis and N. gonorrhoeae and Is Effective at Reducing Bacterial Infection Load

    Neisseria meningitidis and Neisseria gonorrhoeae, two highly related species that might have emerged from a common commensal ancestor, constitute major human threats. Vaccines are available to prevent N. meningitidis infection,...

    Eve Bernet, Marthe Lebughe, Antony T. Vincent, Mohammad Mehdi Haghdoost, Golara Golbaghi, Steven Laplante, Annie Castonguay, Frederic J. Veyrier
  • Antimicrobial Resistance of <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> Isolates from High-Risk Men in Johannesburg, South Africa
    Epidemiology and Surveillance
    Antimicrobial Resistance of Neisseria gonorrhoeae Isolates from High-Risk Men in Johannesburg, South Africa

    Neisseria gonorrhoeae antimicrobial drug resistance has emerged worldwide; however, the situation in sub-Saharan Africa is not well documented. We investigated the molecular epidemiology and occurrence of antimicrobial resistance in Neisseria gonorrhoeae infections in two core transmission groups of...

    Liteboho D. Maduna, Marleen M. Kock, Brian M. J. W. van der Veer, Oscar Radebe, James McIntyre, Lieke B. van Alphen, Remco P. H. Peters
  • Open Access
    Relationship between Gepotidacin Exposure and Prevention of On-Therapy Resistance Amplification in a <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> Hollow-Fiber <em>In Vitro</em> Infection Model
    Mechanisms of Resistance
    Relationship between Gepotidacin Exposure and Prevention of On-Therapy Resistance Amplification in a Neisseria gonorrhoeae Hollow-Fiber In Vitro Infection Model

    Multidrug-resistant Neisseria gonorrhoeae has emerged as a threat to global health. The relationship between gepotidacin exposure and prevention of on-therapy amplification of drug-resistant N. gonorrhoeae was examined using a 7-day hollow-fiber in vitro infection model. The study design...

    Brian D. VanScoy, Nicole E. Scangarella-Oman, Steven Fikes, Sharon Min, Jianzhong Huang, Karen Ingraham, Sujata M. Bhavnani, Haley Conde, Paul G. Ambrose
  • Genomic Analysis Reveals Antibiotic-Susceptible Clones and Emerging Resistance in <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> in Saskatchewan, Canada
    Epidemiology and Surveillance
    Genomic Analysis Reveals Antibiotic-Susceptible Clones and Emerging Resistance in Neisseria gonorrhoeae in Saskatchewan, Canada

    Whole-genome sequencing was used to identify mutations in antibiotic resistance-conferring genes to compare susceptibility predictions with MICs and to ascertain strain types in 99 isolates of Neisseria gonorrhoeae. Genotypes associated with susceptibility, as well as MIC creep or emerging resistance, were noted. Phylogenomic analysis revealed three distinctive clades...

    Nidhi R. Parmar, Reema Singh, Irene Martin, Sumudu R. Perera, Walter Demczuk, Anthony Kusalik, Jessica Minion, Jo-Anne R. Dillon
  • Genomic Characterization of <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> Strains from 2016 U.S. Sentinel Surveillance Displaying Reduced Susceptibility to Azithromycin
    Epidemiology and Surveillance
    Genomic Characterization of Neisseria gonorrhoeae Strains from 2016 U.S. Sentinel Surveillance Displaying Reduced Susceptibility to Azithromycin

    In 2016, the proportion of Neisseria gonorrhoeae isolates with reduced susceptibility to azithromycin rose to 3.6%. A phylogenetic analysis of 334 N. gonorrhoeae isolates collected in 2016 revealed a single, geographically diverse lineage of isolates with MICs of 2 to 16 μg/ml that carried a mosaic-...

    Matthew W. Schmerer, A. Jeanine Abrams, Sandra Seby, Jesse C. Thomas, John Cartee, Sean Lucking, Eshaw Vidyaprakash, Cau D. Pham, Samera Sharpe, Kevin Pettus, Sancta B. St. Cyr, Elizabeth A. Torrone, Ellen N. Kersh, Antimicrobial-Resistant Neisseria gonorrhoeae Working Group, Kim M. Gernert, Antimicrobial-Resistant Neisseria gonorrhoeae Working Group
  • Equations To Predict Antimicrobial MICs in <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> Using Molecular Antimicrobial Resistance Determinants
    Mechanisms of Resistance
    Equations To Predict Antimicrobial MICs in Neisseria gonorrhoeae Using Molecular Antimicrobial Resistance Determinants

    The emergence of Neisseria gonorrhoeae strains that are resistant to azithromycin and extended-spectrum cephalosporins represents a public health threat, that of untreatable gonorrhea infections. Multivariate regression modeling was used to determine the contributions of molecular antimicrobial resistance determinants to the overall antimicrobial MICs for ceftriaxone...

    Walter Demczuk, Irene Martin, Pam Sawatzky, Vanessa Allen, Brigitte Lefebvre, Linda Hoang, Prenilla Naidu, Jessica Minion, Paul VanCaeseele, David Haldane, David W. Eyre, Michael R. Mulvey
  • A Loop-Mediated Isothermal Amplification Assay Targeting <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> <em>penA</em>-60.001
    Mechanisms of Resistance
    A Loop-Mediated Isothermal Amplification Assay Targeting Neisseria gonorrhoeae penA-60.001

    Ceftriaxone (CRO) is widely used as the first-line treatment for gonococcal infections. However, CRO-resistant Neisseria gonorrhoeae strains carrying mosaic penA-60.001 have emerged recently and disseminated worldwide. To meet the urgent need to detect these strains, we report here a loop-mediated isothermal amplification (LAMP) assay system that targets...

    Ken Shimuta, Shu-ichi Nakayama, Hideyuki Takahashi, Makoto Ohnishi
  • Repurposing Salicylamide for Combating Multidrug-Resistant <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span>
    Experimental Therapeutics
    Repurposing Salicylamide for Combating Multidrug-Resistant Neisseria gonorrhoeae

    The U.S. Centers for Disease Control and Prevention (CDC) lists Neisseria gonorrhoeae as one of the most urgent antibiotic-resistant threats in the United States. This is due to the emergence of clinical isolates that have developed resistance to nearly every antibiotic used to treat gonorrhea and highlights the critical need to find new therapeutics.

    ...
    Marwa Alhashimi, Abdelrahman Mayhoub, Mohamed N. Seleem
  • Open Access
    Trends and Risk Factors for Antimicrobial-Resistant <em>Neisseria gonorrhoeae</em>, Melbourne, Australia, 2007 to 2018
    Editor's Pick Epidemiology and Surveillance
    Trends and Risk Factors for Antimicrobial-Resistant Neisseria gonorrhoeae, Melbourne, Australia, 2007 to 2018

    Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a major public health problem. Traditionally, AMR surveillance programs for N. gonorrhoeae have focused mainly on laboratory data to describe the prevalence and trends of resistance. However, integrating individual-level risk factors (e.g.,...

    Deborah A. Williamson, Christopher K. Fairley, Benjamin P. Howden, Marcus Y. Chen, Kerrie Stevens, Vesna De Petra, Ian Denham, Eric P. F. Chow

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