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Nitroreductases

  • Susceptibility
    Exploiting the Drug-Activating Properties of a Novel Trypanosomal Nitroreductase
    Belinda S. Hall, Xinghua Wu, Longqin Hu, Shane R. Wilkinson
  • Mechanisms of Action: Physiological Effects
    Giardia, Entamoeba, and Trichomonas Enzymes Activate Metronidazole (Nitroreductases) and Inactivate Metronidazole (Nitroimidazole Reductases)
    Dibyarupa Pal, Sulagna Banerjee, Jike Cui, Aaron Schwartz, Sudip K. Ghosh, John Samuelson
  • Mechanisms of Action: Physiological Effects
    Chloramphenicol Is a Substrate for a Novel Nitroreductase Pathway in Haemophilus influenzae
    Arnold L. Smith, Alice L. Erwin, Toni Kline, William C. T. Unrath, Kevin Nelson, Allan Weber, William N. Howald
  • Mechanisms of Action: Physiological Effects
    A Novel Giardia lamblia Nitroreductase, GlNR1, Interacts with Nitazoxanide and Other Thiazolides
    Joachim Müller, Jonathan Wastling, Sanya Sanderson, Norbert Müller, Andrew Hemphill
  • Mechanisms of Resistance
    Mutational Analysis of Metronidazole Resistance in Helicobacter pylori
    Jill M. Moore, Nina R. Salama
  • Mechanisms of Action: Physiological Effects
    Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori
    Gary Sisson, Avery Goodwin, Ausra Raudonikiene, Nicky J. Hughes, Asish K. Mukhopadhyay, Douglas E. Berg, Paul S. Hoffman
  • Mechanisms of Resistance
    DNA Sequence Analysis of rdxA andfrxA from 12 Pairs of Metronidazole-Sensitive and -Resistant Clinical Helicobacter pyloriIsolates
    D. H. Kwon, K. Hulten, M. Kato, J. J. Kim, M. Lee, F. A. K. El-Zaatari, M. S. Osato, D. Y. Graham
  • Mechanisms of Resistance
    Mouse-Colonizing Helicobacter pylori SS1 Is Unusually Susceptible to Metronidazole Due to Two Complementary Reductase Activities
    Jin-Yong Jeong, Douglas E. Berg
  • Mechanisms of Resistance
    Frequent Association between Alteration of therdxA Gene and Metronidazole Resistance in French and North African Isolates of Helicobacter pylori
    Jacques Tankovic, Dominique Lamarque, Jean-Charles Delchier, Claude-James Soussy, Agnes Labigne, Peter J. Jenks
  • Mechanisms of Resistance
    Isolation of Nitrofurantoin-Resistant Mutants of Nitroreductase-Producing Clostridium sp. Strains from the Human Intestinal Tract
    Fatemeh Rafii, Eugene B. Hansen
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