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nontuberculous mycobacteria

  • Differential <em>In Vitro</em> Activities of Individual Drugs and Bedaquiline-Rifabutin Combinations against Actively Multiplying and Nutrient-Starved <span class="named-content genus-species" id="named-content-1">Mycobacterium abscessus</span>
    Experimental Therapeutics
    Differential In Vitro Activities of Individual Drugs and Bedaquiline-Rifabutin Combinations against Actively Multiplying and Nutrient-Starved Mycobacterium abscessus

    Current treatment options for lung disease caused by Mycobacterium abscessus complex infections have limited effectiveness. To maximize the use of existing antibacterials and to help inform regimen design for treatment, we assessed the in vitro bactericidal activity of single drugs against actively multiplying and net nonreplicating...

    Jin Lee, Nicole Ammerman, Anusha Agarwal, Maram Naji, Si-Yang Li, Eric Nuermberger
  • KatG as Counterselection Marker for Nontuberculous Mycobacteria
    Letter to the Editor
    KatG as Counterselection Marker for Nontuberculous Mycobacteria
    Aron Gagliardi, Petra Selchow, Sakshi Luthra, Daniel Schäfle, Bettina Schulthess, Peter Sander
  • Open Access
    TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against <span class="named-content genus-species" id="named-content-1">Mycobacterium abscessus</span>
    Experimental Therapeutics
    TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus

    Lung disease caused by Mycobacterium abscessus is very difficult to cure, and treatment failure rates are high. The antituberculosis drug bedaquiline (BDQ) is used as salvage therapy against this dreadful disease. However, BDQ is highly lipophilic, displays a long terminal half-life, and presents a cardiotoxicity liability associated with QT interval prolongation....

    Jickky Palmae Sarathy, Uday S. Ganapathy, Matthew D. Zimmerman, Véronique Dartois, Martin Gengenbacher, Thomas Dick
  • Open Access
    Rifabutin Is Active against <span class="named-content genus-species" id="named-content-1">Mycobacterium abscessus</span> in Mice
    Editor's Pick Experimental Therapeutics
    Rifabutin Is Active against Mycobacterium abscessus in Mice

    There is no reliable cure for Mycobacterium abscessus lung disease. Rifampin is not used clinically due to poor in vitro potency. In contrast, we have shown that rifabutin, another approved rifamycin used to treat tuberculosis, is potent in vitro against M. abscessus. Here, we...

    Thomas Dick, Sung Jae Shin, Won-Jung Koh, Véronique Dartois, Martin Gengenbacher
  • <em>In Vitro</em> Activity of Bedaquiline and Delamanid against Nontuberculous Mycobacteria, Including Macrolide-Resistant Clinical Isolates
    Susceptibility
    In Vitro Activity of Bedaquiline and Delamanid against Nontuberculous Mycobacteria, Including Macrolide-Resistant Clinical Isolates

    We evaluated the in vitro activities of the antimicrobial drugs bedaquiline and delamanid against the major pathogenic nontuberculous mycobacteria (NTM). Delamanid showed high MIC values for all NTM except Mycobacterium kansasii. However, bedaquiline showed low MIC values for the major pathogenic NTM, including...

    Dae Hun Kim, Byung Woo Jhun, Seong Mi Moon, Su-Young Kim, Kyeongman Jeon, O Jung Kwon, Hee Jae Huh, Nam Yong Lee, Sung Jae Shin, Charles L. Daley, Won-Jung Koh
  • Improved Performance Predicting Clarithromycin Resistance in <em>Mycobacterium abscessus</em> on an Independent Data Set
    Letter to the Editor
    Improved Performance Predicting Clarithromycin Resistance in Mycobacterium abscessus on an Independent Data Set
    Samuel Lipworth, Natasha Hough, Ruaridh Buchanan, E. Grace Smith, Esther Robinson, Eliza Alexander, Tim Peto, Derrick Crook, Timothy Walker
  • <em>In Vitro</em> Activities of Bedaquiline and Delamanid against Nontuberculous Mycobacteria Isolated in Beijing, China
    Susceptibility
    In Vitro Activities of Bedaquiline and Delamanid against Nontuberculous Mycobacteria Isolated in Beijing, China

    Due to the natural resistance of nontuberculous mycobacteria (NTM) against multiple antibiotics, treatment of infections caused by them is often long-course and less successful. The main objective of our study was the evaluation of in vitro susceptibility of 209 isolates consisting of different NTM species against bedaquiline and delamanid. Furthermore, reference strains of 33 rapidly growing mycobacterium (RGM) species and 19...

    Xia Yu, XiaoPan Gao, Chenghai Li, Jingjing Luo, Shuan Wen, Tingting Zhang, Yifeng Ma, Lingling Dong, Fen Wang, Hairong Huang
  • Species Distribution and Macrolide Susceptibility of <em>Mycobacterium fortuitum</em> Complex Clinical Isolates
    Mechanisms of Resistance
    Species Distribution and Macrolide Susceptibility of Mycobacterium fortuitum Complex Clinical Isolates

    The understanding of species distribution and inducible macrolide resistance in the Mycobacterium fortuitum complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were M. fortuitum, followed by M. peregrinum...

    Su-Young Kim, Seong Mi Moon, Byung Woo Jhun, O Jung Kwon, Hee Jae Huh, Nam Yong Lee, Seung Heon Lee, Sung Jae Shin, Shannon H. Kasperbauer, Gwen A. Huitt, Charles L. Daley, Won-Jung Koh
  • <em>In Vitro</em> Activities of Omadacycline against Rapidly Growing Mycobacteria
    Susceptibility
    In Vitro Activities of Omadacycline against Rapidly Growing Mycobacteria

    The in vitro activity of omadacycline, a new tetracycline derivative, was evaluated against isolates of Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum using a broth microtiter dilution assay...

    Carolyn Shoen, David Benaroch, Mary Sklaney, Michael Cynamon
  • Indole-2-Carboxamides Are Active against <em>Mycobacterium abscessus</em> in a Mouse Model of Acute Infection
    Chemistry; Biosynthesis
    Indole-2-Carboxamides Are Active against Mycobacterium abscessus in a Mouse Model of Acute Infection

    Nontuberculous mycobacteria (NTM) pathogens particularly infect patients with structural lung disorders. We previously reported novel indole-2-carboxamides (ICs) that are active against a wide panel of NTM pathogens.

    Amit N. Pandya, Pavan K. Prathipati, Pooja Hegde, Wei Li, Kyle F. Graham, Subhra Mandal, Kristen M. Drescher, Christopher J. Destache, Diane Ordway, Mary Jackson, E. Jeffrey North

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