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onychomycosis

  • Open Access
    Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate
    Experimental Therapeutics
    Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate

    Onychomycosis is a common, difficult-to-treat nail infection that is mainly caused by dermatophytes. Current therapies are not wholly effective and are associated with manifold side effects.

    Derry K. Mercer, Colin S. Stewart, Lorna Miller, Jennifer Robertson, Vanessa M. S. Duncan, Deborah A. O’Neil
  • Low <em>In Vitro</em> Antifungal Activity of Tavaborole against Yeasts and Molds from Onychomycosis
    Susceptibility
    Low In Vitro Antifungal Activity of Tavaborole against Yeasts and Molds from Onychomycosis

    The in vitro activity of tavaborole, an FDA-approved antifungal drug, was compared to that of four antifungal agents against 170 clinical fungal isolates originating from patients with onychomycosis. Tavaborole had low activity against all isolates compared to itraconazole, terbinafine, and fluconazole, the principal choices for treatment of onychomycosis.

    Mahdi Abastabar, Iman Haghani, Tahereh Shokohi, Mohammad Taghi Hedayati, Seyed Reza Aghili, Ali Jedi, Sulmaz Dadashi, Shafigheh Shabanzadeh, Tahereh Hosseini, Narges Aslani, Jacques F. Meis, Hamid Badali
  • Clinical Therapeutics
    Nitric Oxide-Releasing Macromolecule Exhibits Broad-Spectrum Antifungal Activity and Utility as a Topical Treatment for Superficial Fungal Infections
    Nathan Stasko, Kimberly McHale, Stanley J. Hollenbach, Megan Martin, Ryan Doxey
  • Pharmacology
    In Vitro Human Onychopharmacokinetic and Pharmacodynamic Analyses of ME1111, a New Topical Agent for Onychomycosis
    Natsuki Kubota-Ishida, Naomi Takei-Masuda, Kaori Kaneda, Yu Nagira, Tsubasa Chikada, Masahiro Nomoto, Yuji Tabata, Sho Takahata, Kazunori Maebashi, Xiaoying Hui, Howard I. Maibach
  • Clinical Therapeutics
    Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models
    Luisa Christensen, Rob Turner, Sean Weaver, Francesco Caserta, Lisa Long, Mahmoud Ghannoum, Marc Brown
  • Experimental Therapeutics
    Therapeutic Efficacy of Topically Applied KP-103 against Experimental Tinea Unguium in Guinea Pigs in Comparison with Amorolfine and Terbinafine
    Yoshiyuki Tatsumi, Mamoru Yokoo, Hisato Senda, Kazuaki Kakehi
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