oxazolidinones
Letter to the EditorMyelosuppression with Oxazolidinones: Are There Differences?
PharmacologyUse of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid PhosphateTedizolid phosphate, the prodrug of the active antibiotic tedizolid, is an oxazolidinone for the treatment of acute bacterial skin and skin structure infections. Studies in a mouse thigh infection model demonstrated that tedizolid has improved potency and pharmacokinetics/pharmacodynamics (PK/PD) compared with those of linezolid.
Mechanisms of ResistanceEmergence and Within-Host Genetic Evolution of Methicillin-Resistant Staphylococcus aureus Resistant to Linezolid in a Cystic Fibrosis PatientMethicillin-resistant Staphylococcus aureus (MRSA) infection has increased in recent years among cystic fibrosis (CF) patients. Linezolid (LZD) is one of the antistaphylococcal antibiotics widely used in this context.
- Experimental TherapeuticsIn Vitro and In Vivo Activities of Contezolid (MRX-I) against Mycobacterium tuberculosis
- Mechanisms of ResistanceIn Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis
