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paradoxical effect

  • Echinocandins for the Treatment of Invasive Aspergillosis: from Laboratory to Bedside
    Minireview
    Echinocandins for the Treatment of Invasive Aspergillosis: from Laboratory to Bedside

    Echinocandins (caspofungin, micafungin, anidulafungin), targeting β-1,3-glucan synthesis of the cell wall, represent one of the three currently available antifungal drug classes for the treatment of invasive fungal infections. Despite their limited antifungal activity against Aspergillus spp., echinocandins are considered an alternative option for the treatment of invasive aspergillosis (IA).

    Marion Aruanno, Emmanouil Glampedakis, Frédéric Lamoth
  • Link between Heat Shock Protein 90 and the Mitochondrial Respiratory Chain in the Caspofungin Stress Response of <span class="named-content genus-species" id="named-content-1">Aspergillus fumigatus</span>
    Mechanisms of Resistance
    Link between Heat Shock Protein 90 and the Mitochondrial Respiratory Chain in the Caspofungin Stress Response of Aspergillus fumigatus

    Aspergillus fumigatus is an opportunistic mold responsible for invasive aspergillosis. Triazoles (e.g., voriconazole) represent the first-line treatment, but emerging resistance is of concern.

    M. Aruanno, D. Bachmann, D. Sanglard, F. Lamoth
  • Mechanisms of Resistance
    Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in β-1,3-Glucan Synthase Localization
    Sergio D. Moreno-Velásquez, Constanze Seidel, Praveen R. Juvvadi, William J. Steinbach, Nick D. Read
  • Mechanisms of Resistance
    The Paradoxical Effect of Echinocandins in Aspergillus fumigatus Relies on Recovery of the β-1,3-Glucan Synthase Fks1
    Veronika Loiko, Johannes Wagener
  • Susceptibility
    Frequency of the Paradoxical Effect Measured Using the EUCAST Procedure with Micafungin, Anidulafungin, and Caspofungin against Candida Species Isolates Causing Candidemia
    Laura Judith Marcos-Zambrano, Pilar Escribano, Carlos Sánchez-Carrillo, Emilio Bouza, Jesús Guinea
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