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pentoxifylline

  • Vancomycin Is Protective in a Neonatal Mouse Model of <em>Staphylococcus epidermidis</em>-Potentiated Hypoxic-Ischemic Brain Injury
    Editor's Pick Experimental Therapeutics
    Vancomycin Is Protective in a Neonatal Mouse Model of Staphylococcus epidermidis-Potentiated Hypoxic-Ischemic Brain Injury

    Infection is correlated with increased risk of neurodevelopmental sequelae in preterm infants. In modeling neonatal brain injury, Toll-like receptor agonists have often been used to mimic infections and induce inflammation. Using the most common cause of bacteremia in preterm infants, Staphylococcus epidermidis, we present a more clinically relevant neonatal mouse...

    Jacqueline C. Y. Lai, Pernilla Svedin, C. Joakim Ek, Amin Mottahedin, Xiaoyang Wang, Ofer Levy, Andrew Currie, Tobias Strunk, Carina Mallard
  • Open Access
    Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes <em>In Vitro</em>
    Biologic Response Modifiers
    Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro

    Neonatal sepsis and its accompanying inflammatory response contribute to substantial morbidity and mortality. Pentoxifylline (PTX), a phosphodiesterase inhibitor which suppresses transcription and production of proinflammatory cytokines, is a candidate adjunctive therapy for newborn sepsis.

    Esther M. Speer, Elizabeth Diago-Navarro, Lukasz S. Ozog, David J. Dowling, Wei Hou, Mahnoor Raheel, Bettina C. Fries, Ofer Levy
  • Pharmacology
    Pharmacokinetics of Pentoxifylline and Its Metabolites in Healthy Mice and in Mice Infected with Candida albicans
    Kenneth Miller, Arnold Louie, Aldona L. Baltch, Raymond P. Smith, Patrick J. Davis, Morris A. Gordon
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