persistence
Mechanisms of ResistanceCandida albicans Biofilms Are Generally Devoid of Persister CellsCandida albicans is known for its ability to form biofilms, which are communities of microorganisms embedded in an extracellular matrix developing on different surfaces. Biofilms are highly tolerant to antifungal therapy.
Mechanisms of Action: Physiological EffectsIsoniazid Bactericidal Activity Involves Electron Transport Chain PerturbationAccumulating evidence suggests that the bactericidal activity of some antibiotics may not be directly initiated by target inhibition. The activity of isoniazid (INH), a key first-line bactericidal antituberculosis drug currently known to inhibit mycolic acid synthesis, becomes extremely poor under stress conditions, such as hypoxia and starvation.
- Mechanisms of Action: Physiological EffectsRelationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System
- Mechanisms of ResistanceDeterminants of Extreme β-Lactam Tolerance in the Burkholderia pseudomallei Complex
- Mechanisms of Action: Physiological EffectsThe Alternative Sigma Factors SigE and SigB Are Involved in Tolerance and Persistence to Antitubercular Drugs
- Mechanisms of ResistanceClinical Relevance of Type II Fatty Acid Synthesis Bypass in Staphylococcus aureus
- Mechanisms of Action: Physiological EffectsSubinhibitory Concentrations of Bacteriostatic Antibiotics Induce relA-Dependent and relA-Independent Tolerance to β-Lactams