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persistence

  • Deletion of <em>pknG</em> Abates Reactivation of Latent <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span> in Mice
    Experimental Therapeutics
    Deletion of pknG Abates Reactivation of Latent Mycobacterium tuberculosis in Mice

    Eradication of tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), has been a challenge due to its uncanny ability to survive in a dormant state inside host granulomas for decades. Mtb rewires its metabolic and redox regulatory networks to survive in the hostile hypoxic and nutrient-limiting environment, facilitating the formation of drug-...

    Mehak Zahoor Khan, Vinay Kumar Nandicoori
  • (p)ppGpp and Its Role in Bacterial Persistence: New Challenges
    Minireview
    (p)ppGpp and Its Role in Bacterial Persistence: New Challenges

    Antibiotic failure not only is due to the development of resistance by pathogens but can also often be explained by persistence and tolerance. Persistence and tolerance can be included in the “persistent phenotype,” with high relevance for clinics. Two of the most important molecular mechanisms involved in tolerance and persistence are toxin-antitoxin (TA) modules and signaling via guanosine pentaphosphate/tetraphosphate [(p)ppGpp],...

    Olga Pacios, Lucia Blasco, Inés Bleriot, Laura Fernandez-Garcia, Antón Ambroa, María López, German Bou, Rafael Cantón, Rodolfo Garcia-Contreras, Thomas K. Wood, Maria Tomás
  • Adaptation of <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span> to Biofilm Growth Is Genetically Linked to Drug Tolerance
    Mechanisms of Resistance
    Adaptation of Mycobacterium tuberculosis to Biofilm Growth Is Genetically Linked to Drug Tolerance

    Mycobacterium tuberculosis spontaneously grows at the air-medium interface, forming pellicle biofilms, which harbor more drug-tolerant persisters than planktonic cultures. The underlying basis for increased persisters in M. tuberculosis biofilms is unknown.

    Jacob P. Richards, Wenlong Cai, Nicholas A. Zill, Wenjun Zhang, Anil K. Ojha
  • Open Access
    Repeated Isolation of Extended-Spectrum-β-Lactamase-Positive <em>Escherichia coli</em> Sequence Types 648 and 131 from Community Wastewater Indicates that Sewage Systems Are Important Sources of Emerging Clones of Antibiotic-Resistant Bacteria
    Editor's Pick Mechanisms of Resistance
    Repeated Isolation of Extended-Spectrum-β-Lactamase-Positive Escherichia coli Sequence Types 648 and 131 from Community Wastewater Indicates that Sewage Systems Are Important Sources of Emerging Clones of Antibiotic-Resistant Bacteria

    Antibiotic resistance in bacteria is an emerging problem globally. Resistant bacteria are found in human and animal microbiota, as well as in the environment. Wastewater receives bacteria from all these sources and thus can provide a measurement of abundance and diversity of antibiotic-resistant bacteria circulating in communities. In this study, water samples were collected from a wastewater pump station in a Norwegian suburban...

    Erik Paulshus, Kaisa Thorell, Jessica Guzman-Otazo, Enrique Joffre, Patricia Colque, Inger Kühn, Roland Möllby, Henning Sørum, Åsa Sjöling
  • <em>Candida albicans</em> Biofilms Are Generally Devoid of Persister Cells
    Mechanisms of Resistance
    Candida albicans Biofilms Are Generally Devoid of Persister Cells

    Candida albicans is known for its ability to form biofilms, which are communities of microorganisms embedded in an extracellular matrix developing on different surfaces. Biofilms are highly tolerant to antifungal therapy.

    Iryna Denega, Christophe d’Enfert, Sophie Bachellier-Bassi
  • Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation
    Mechanisms of Action: Physiological Effects
    Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation

    Accumulating evidence suggests that the bactericidal activity of some antibiotics may not be directly initiated by target inhibition. The activity of isoniazid (INH), a key first-line bactericidal antituberculosis drug currently known to inhibit mycolic acid synthesis, becomes extremely poor under stress conditions, such as hypoxia and starvation.

    Sheng Zeng, Karine Soetaert, Faustine Ravon, Marie Vandeput, Dirk Bald, Jean-Michel Kauffmann, Vanessa Mathys, Ruddy Wattiez, Véronique Fontaine
  • Open Access
    Mechanisms of Action: Physiological Effects
    Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System
    Laura Fernández-García, Felipe Fernandez-Cuenca, Lucía Blasco, Rafael López-Rojas, Anton Ambroa, María Lopez, Álvaro Pascual, Germán Bou, María Tomás
  • Mechanisms of Resistance
    Determinants of Extreme β-Lactam Tolerance in the Burkholderia pseudomallei Complex
    Kiara Held, Joe Gasper, Sarah Morgan, Richard Siehnel, Pradeep Singh, Colin Manoil
  • Open Access
    Pharmacology
    Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum
    Jansy P. Sarathy, Laura E. Via, Danielle Weiner, Landry Blanc, Helena Boshoff, Eliseo A. Eugenin, Clifton E. Barry, Véronique A. Dartois
  • Mechanisms of Action: Physiological Effects
    The Alternative Sigma Factors SigE and SigB Are Involved in Tolerance and Persistence to Antitubercular Drugs
    Davide Pisu, Roberta Provvedi, Dulce Mata Espinosa, Jorge Barrios Payan, Francesca Boldrin, Giorgio Palù, Rogelio Hernandez-Pando, Riccardo Manganelli

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