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piperacillin

  • Population Pharmacokinetics of Piperacillin following Continuous Infusion in Critically Ill Patients and Impact of Renal Function on Target Attainment
    Clinical Therapeutics
    Population Pharmacokinetics of Piperacillin following Continuous Infusion in Critically Ill Patients and Impact of Renal Function on Target Attainment

    Pharmacokinetic changes are often seen in patients with severe infections. Administration by continuous infusion has been suggested to optimize antibiotic exposure and pharmacokinetic/pharmacodynamic (PK/PD) target attainment for β-lactams. In an observational study, unbound piperacillin concentrations (n = 196) were assessed in 78 critically ill patients following continuous infusion of piperacillin-tazobactam (ratio 8:1). The...

    Vibeke Klastrup, Anders Thorsted, Merete Storgaard, Steffen Christensen, Lena E. Friberg, Kristina Öbrink-Hansen
  • Systematic Review and Meta-analysis of the Association of Acute Kidney Injury with the Concomitant Use of Vancomycin and Piperacillin-Tazobactam in Children
    Clinical Therapeutics
    Systematic Review and Meta-analysis of the Association of Acute Kidney Injury with the Concomitant Use of Vancomycin and Piperacillin-Tazobactam in Children

    Concomitant use of vancomycin plus piperacillin-tazobactam (TZP) has been associated with increased risk of acute kidney injury (AKI) in hospitalized adults. In this systematic review and meta-analysis, we searched PubMed and EMBASE for pediatric studies examining this hypothesis, with reference to vancomycin monotherapy or in combination with another beta-lactam antibiotic. Of 1,381 nonduplicate studies, 10 met our inclusion criteria...

    Markos Kalligeros, Spyridon A. Karageorgos, Fadi Shehadeh, Ioannis M. Zacharioudakis, Eleftherios Mylonakis
  • The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span>
    Editor's Pick Mechanisms of Action: Physiological Effects
    The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus

    The quinazolinones are a new class of antibacterials with in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA). The quinazolinones target cell wall biosynthesis and have a unique mechanism of action by binding to the allosteric site of penicillin-binding protein 2a (PBP 2a).

    Jeshina Janardhanan, Renee Bouley, Siseth Martínez-Caballero, Zhihong Peng, Mayte Batuecas-Mordillo, Jayda E. Meisel, Derong Ding, Valerie A. Schroeder, William R. Wolter, Kiran V. Mahasenan, Juan A. Hermoso, Shahriar Mobashery, Mayland Chang
  • Pharmacology
    Population Pharmacokinetics of Piperacillin in Sepsis Patients: Should Alternative Dosing Strategies Be Considered?
    Maria Goul Andersen, Anders Thorsted, Merete Storgaard, Anders N. Kristoffersson, Lena E. Friberg, Kristina Öbrink-Hansen
  • Pharmacology
    Using Population Pharmacokinetic Modeling and Monte Carlo Simulations To Determine whether Standard Doses of Piperacillin in Piperacillin-Tazobactam Regimens Are Adequate for the Management of Febrile Neutropenia
    Fekade Bruck Sime, Uwe Hahn, Morgyn S. Warner, Ing Soo Tiong, Michael S. Roberts, Jeffrey Lipman, Sandra L. Peake, Jason A. Roberts
  • Letter to the Editor
    Reply to Aitken et al., “Should Piperacillin-Tazobactam Be Used as Definitive Therapy against Enterobacteriaceae Harboring Inducible AmpC β-Lactamases?”
    Lucy Cheng, Brian C. Nelson, Monica Mehta, Qiuhu Shi, Angela Gomez-Simmonds, Anne-Catrin Uhlemann
  • Letter to the Editor
    Should Piperacillin-Tazobactam Be Used as Definitive Therapy against Enterobacteriaceae Harboring Inducible AmpC β-Lactamases?
    Samuel L. Aitken, Farnaz Foolad, Patrick M. McDaneld
  • Pharmacology
    Neurotoxic Concentration of Piperacillin during Continuous Infusion in Critically Ill Patients
    Marie-Charlotte Quinton, Sandra Bodeau, Loay Kontar, Yoann Zerbib, Julien Maizel, Michel Slama, Kamel Masmoudi, Anne-Sophie Lemaire-Hurtel, Youssef Bennis
  • Pharmacology
    Population Pharmacokinetics of Piperacillin in Nonobese, Obese, and Morbidly Obese Critically Ill Patients
    Abdulaziz S. Alobaid, Steven C. Wallis, Paul Jarrett, Therese Starr, Janine Stuart, Melissa Lassig-Smith, Jenny Lisette Ordóñez Mejia, Michael S. Roberts, Claire Roger, Andrew A. Udy, Jeffrey Lipman, Jason A. Roberts
  • Pharmacology
    Pharmacokinetics of Intravenous Piperacillin Administration in Patients Undergoing On-Line Hemodiafiltration
    Kook-Hwan Oh, Chiweon Kim, Hankyu Lee, Hajeong Lee, Ji Yong Jung, Nam Joong Kim, Kyung-Sang Yu, Kwang-Hee Shin, In-Jin Jang, Curie Ahn

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