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plasmid

  • Epidemic Territorial Spread of IncP-2-Type VIM-2 Carbapenemase-Encoding Megaplasmids in Nosocomial <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Populations
    Epidemiology and Surveillance
    Epidemic Territorial Spread of IncP-2-Type VIM-2 Carbapenemase-Encoding Megaplasmids in Nosocomial Pseudomonas aeruginosa Populations

    In 2003 to 2004, the first five VIM-2 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa (MPPA) isolates with an In4-like integron, In461 (aadB-blaVIM-2-aadA6), on conjugative plasmids were identified in three hospitals in Poland. In 2005 to 2015, MPPA expanded much in the country, and as many as 80 isolates in a...

    Paweł Urbanowicz, Ibrahim Bitar, Radosław Izdebski, Anna Baraniak, Elżbieta Literacka, Jaroslav Hrabák, Marek Gniadkowski
  • IS<em>26</em> Mediates the Acquisition of Tigecycline Resistance Gene Cluster <em>tmexCD1-toprJ1</em> by IncHI1B-FIB Plasmids in <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> and <span class="named-content genus-species" id="named-content-2">Klebsiella quasipneumoniae</span> from Food Market Sewage
    Letter to the Editor
    IS26 Mediates the Acquisition of Tigecycline Resistance Gene Cluster tmexCD1-toprJ1 by IncHI1B-FIB Plasmids in Klebsiella pneumoniae and Klebsiella quasipneumoniae from Food Market Sewage
    Miao Wan, Xun Gao, Luchao Lv, Zhongpeng Cai, Jian-Hua Liu
  • Rapid Increase of CTX-M-Producing <span class="named-content genus-species" id="named-content-1">Shigella sonnei</span> Isolates in Switzerland Due to Spread of Common Plasmids and International Clones
    Mechanisms of Resistance
    Rapid Increase of CTX-M-Producing Shigella sonnei Isolates in Switzerland Due to Spread of Common Plasmids and International Clones

    The Swiss Centre for Antibiotic Resistance (ANRESIS) has recently noted an increase of extended-spectrum cephalosporin-resistant (ESC-R) Shigella sonnei isolates nationwide (3.8% in 2016 versus 37.5% in 2019). To understand this phenomenon, we analyzed 25 representative isolates (of which 14 were ESC-R) collected in Switzerland during 2016 to 2019. Whole-genome...

    Edgar I. Campos-Madueno, Odette J. Bernasconi, Aline I. Moser, Peter M. Keller, Francesco Luzzaro, Carola Maffioli, Thomas Bodmer, Andreas Kronenberg, Andrea Endimiani
  • CRISPR-Cas9-Mediated Carbapenemase Gene and Plasmid Curing in Carbapenem-Resistant <em>Enterobacteriaceae</em>
    Mechanisms of Resistance
    CRISPR-Cas9-Mediated Carbapenemase Gene and Plasmid Curing in Carbapenem-Resistant Enterobacteriaceae

    Combating plasmid-mediated carbapenem resistance is essential to control and prevent the dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Here, we conducted a proof-of-concept study to demonstrate that CRISPR-Cas9-mediated resistance gene and plasmid curing can effectively resensitize CRE to carbapenems. A novel CRISPR-Cas9-mediated plasmid-curing system (pCasCure) was developed and electrotransferred into...

    Mingju Hao, Yuzhang He, Haifang Zhang, Xiao-Ping Liao, Ya-Hong Liu, Jian Sun, Hong Du, Barry N. Kreiswirth, Liang Chen
  • Characterization of FosL1, a Plasmid-Encoded Fosfomycin Resistance Protein Identified in <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Mechanisms of Resistance
    Characterization of FosL1, a Plasmid-Encoded Fosfomycin Resistance Protein Identified in Escherichia coli

    Fosfomycin is gaining renewed interest for treating urinary tract infections. Monitoring fosfomycin resistance is therefore important in order to detect the emergence of novel resistance mechanisms. Here, we used the Rapid Fosfomycin NP test to screen a collection of extended-spectrum-β-lactamase-producing Escherichia coli isolates from Switzerland and found a...

    Nicolas Kieffer, Laurent Poirel, Marie-Christine Descombes, Patrice Nordmann
  • First Occurrence of the OXA-198 Carbapenemase in <em>Enterobacterales</em>
    Mechanisms of Resistance
    First Occurrence of the OXA-198 Carbapenemase in Enterobacterales

    A carbapenem-resistant Citrobacter sp. was recovered from routine screening of multidrug-resistant bacteria. This isolate coproduced OXA-48 and OXA-198. OXA-48 was carried by the prototypical IncL plasmid, whereas OXA-198 was carried by a peculiar IncHI-type plasmid. This carbapenemase gene was inserted within a class 1 integron located on a conjugative plasmid. This report describes the first occurrence of OXA-198 in ...

    Rémy A. Bonnin, Agnès B. Jousset, Lauraine Gauthier, Cécile Emeraud, Delphine Girlich, Aimie Sauvadet, Garance Cotellon, Thomas Jové, Laurent Dortet, Thierry Naas
  • Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, <em>erm</em>(50), in <span class="named-content genus-species" id="named-content-1">Cutibacterium acnes</span>
    Editor's Pick Mechanisms of Resistance
    Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes

    Antimicrobial-resistant Cutibacterium acnes strains have emerged and disseminated throughout the world. The 23S rRNA mutation and erm(X) gene are known as the major resistance determinants of macrolides and clindamycin in C. acnes. We isolated eight high-level macrolide-clindamycin-resistant C. acnes strains with no known resistance...

    Sae Aoki, Keisuke Nakase, Hidemasa Nakaminami, Takeaki Wajima, Nobukazu Hayashi, Norihisa Noguchi
  • Evolution of a 72-Kilobase Cointegrant, Conjugative Multiresistance Plasmid in Community-Associated Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Isolates from the Early 1990s
    Mechanisms of Resistance
    Evolution of a 72-Kilobase Cointegrant, Conjugative Multiresistance Plasmid in Community-Associated Methicillin-Resistant Staphylococcus aureus Isolates from the Early 1990s

    Horizontal transfer of plasmids encoding antimicrobial resistance and virulence determinants has been instrumental in Staphylococcus aureus evolution, including the emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). In the early 1990s, the first CA-MRSA strain isolated in...

    Karina Yui Eto, Neville Firth, Amy M. Davis, Stephen M. Kwong, Marcelina Krysiak, Yung Thin Lee, Frances G. O’Brien, Warren B. Grubb, Geoffrey W. Coombs, Charles S. Bond, Joshua P. Ramsay
  • Conjugative Delivery of CRISPR-Cas9 for the Selective Depletion of Antibiotic-Resistant Enterococci
    Editor's Pick Mechanisms of Resistance
    Conjugative Delivery of CRISPR-Cas9 for the Selective Depletion of Antibiotic-Resistant Enterococci

    The innovation of new therapies to combat multidrug-resistant (MDR) bacteria is being outpaced by the continued rise of MDR bacterial infections. Of particular concern are hospital-acquired infections (HAIs) that are recalcitrant to antibiotic therapies. The Gram-positive intestinal pathobiont Enterococcus faecalis is associated with HAIs, and some strains are MDR....

    Marinelle Rodrigues, Sara W. McBride, Karthik Hullahalli, Kelli L. Palmer, Breck A. Duerkop
  • Plasmid-Mediated <em>mcr-1</em> Colistin Resistance in <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> from a Black Kite in Russia
    Mechanisms of Resistance
    Plasmid-Mediated mcr-1 Colistin Resistance in Escherichia coli from a Black Kite in Russia

    The gene mcr-1 conferring resistance to last-line antibiotic colistin has been reported globally. Here, we describe the first detection of plasmid-mediated colistin resistance in Russian wildlife, an isolate of Escherichia coli sequence type 2280 from a black kite (Milvus migrans) scavenging raptor. Whole-genome sequencing and plasmid transferability...

    Hassan Tarabai, Adam Valcek, Ivana Jamborova, Sergey V. Vazhov, Igor V. Karyakin, Rainer Raab, Ivan Literak, Monika Dolejska

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