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plasmids

  • Cooccurrence of Two <em>tet</em>(X) Variants in an <span class="named-content genus-species" id="named-content-1">Empedobacter brevis</span> Strain of Shrimp Origin
    Letter to the Editor
    Cooccurrence of Two tet(X) Variants in an Empedobacter brevis Strain of Shrimp Origin
    Ruichao Li, Ziyi Liu, Kai Peng, Yuan Liu, Xia Xiao, Zhiqiang Wang
  • Conjugative IncX1 Plasmid Harboring Colistin Resistance Gene <em>mcr-5.1</em> in <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Isolated from Chicken Rice Retailed in Singapore
    Letter to the Editor
    Conjugative IncX1 Plasmid Harboring Colistin Resistance Gene mcr-5.1 in Escherichia coli Isolated from Chicken Rice Retailed in Singapore
    Siyao Guo, Moon Y. F. Tay, Aung Kyaw Thu, Kelyn Lee Ghee Seow, Yang Zhong, Lee Ching Ng, Joergen Schlundt
  • Loss of <em>mcr</em> Genes Mediated by Plasmid Elimination and IS<em>Apl1</em>
    Mechanisms of Resistance
    Loss of mcr Genes Mediated by Plasmid Elimination and ISApl1

    We characterized the stability of a plasmid pCP53-mcr1_3 encoding mcr-1 and mcr-3.19 with and without colistin exposure during cultural passages via S1-pulsed-field gel electrophoresis (PFGE) and nanopore MinION sequencing. Both mcr-1 and mcr-3.19 were missing in certain subclones, mediated by genetic excision (ISApl1-mcr-1-pap2), and deletions of large multidrug resistance (MDR) regions...

    Pei Zhang, Li Bai, Yan Li, Zhiqiang Wang, Ruichao Li
  • The Arginine Deiminase Operon Is Responsible for a Fitness Trade-Off in Extended-Spectrum-β-Lactamase-Producing Strains of <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Epidemiology and Surveillance
    The Arginine Deiminase Operon Is Responsible for a Fitness Trade-Off in Extended-Spectrum-β-Lactamase-Producing Strains of Escherichia coli

    We previously identified an operon involved in an arginine deiminase (ADI) pathway (arc operon) on a CTX-M-producing plasmid from an O102-ST405 strain of Escherichia coli. As the ADI pathway was shown to be involved in the virulence of various Gram-positive bacteria, we tested whether the ADI pathway could be involved in the epidemiological success of...

    Typhaine Billard-Pomares, Olivier Clermont, Miguel Castellanos, Fatma Magdoud, Guilhem Royer, Bénédicte Condamine, Stéphanie Fouteau, Valérie Barbe, David Roche, Stéphane Cruveiller, Claudine Médigue, Dominique Pognard, Jeremy Glodt, Sara Dion, Odile Rigal, Bertrand Picard, Erick Denamur, Catherine Branger
  • Two Hypervirulent <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> Isolates Producing a <em>bla</em><sub>KPC-2</sub> Carbapenemase from a Canadian Patient
    Mechanisms of Resistance
    Two Hypervirulent Klebsiella pneumoniae Isolates Producing a blaKPC-2 Carbapenemase from a Canadian Patient

    This report describes two hypervirulent Klebsiella pneumoniae isolates that produced K. pneumoniae carbapenemase (KPC), which were identified from a rectal swab and a urine culture upon hospital admission. The patient had recently traveled to Greece, where he was hospitalized.

    Laura F. Mataseje, David A. Boyd, Michael R. Mulvey, Yves Longtin
  • Characterization of <em>mcr-5</em>-Harboring <em>Salmonella enterica</em> subsp. <em>enterica</em> Serovar Typhimurium Isolates from Animal and Food Origin in Germany
    Mechanisms of Resistance
    Characterization of mcr-5-Harboring Salmonella enterica subsp. enterica Serovar Typhimurium Isolates from Animal and Food Origin in Germany

    We characterized eight mcr-5-positive Salmonella enterica subsp. enterica serovar Typhimurium sequence type 34 (ST34) isolates obtained from pigs and meat in Germany.

    Maria Borowiak, Jens A. Hammerl, Carlus Deneke, Jennie Fischer, Istvan Szabo, Burkhard Malorny
  • Characterization of Carbapenemase-Producing <span class="named-content genus-species" id="named-content-1">Klebsiella oxytoca</span> in Spain, 2016–2017
    Epidemiology and Surveillance
    Characterization of Carbapenemase-Producing Klebsiella oxytoca in Spain, 2016–2017

    There is little information about carbapenemase-producing (CP) Klebsiella oxytoca, an important nosocomial pathogen. We characterized CP K. oxytoca isolates collected from different Spanish hospitals between January 2016 and October 2017.

    María Pérez-Vazquez, Jesús Oteo-Iglesias, Pedro J. Sola-Campoy, Hugo Carrizo-Manzoni, Verónica Bautista, Noelia Lara, Belén Aracil, Almudena Alhambra, Luis Martínez-Martínez, José Campos, the Spanish Antibiotic Resistance Surveillance Program Collaborating Group
  • Open Access
    Remodeling of pSK1 Family Plasmids and Enhanced Chlorhexidine Tolerance in a Dominant Hospital Lineage of Methicillin-Resistant <em>Staphylococcus aureus</em>
    Editor's Pick Mechanisms of Resistance
    Remodeling of pSK1 Family Plasmids and Enhanced Chlorhexidine Tolerance in a Dominant Hospital Lineage of Methicillin-Resistant Staphylococcus aureus

    Staphylococcus aureus is a significant human pathogen whose evolution and adaptation have been shaped in part by mobile genetic elements (MGEs), facilitating the global spread of extensive antimicrobial resistance. However, our understanding of the evolutionary dynamics surrounding MGEs, in particular, how changes in the structure of multidrug resistance (MDR)...

    Sarah L. Baines, Slade O. Jensen, Neville Firth, Anders Gonçalves da Silva, Torsten Seemann, Glen P. Carter, Deborah A. Williamson, Benjamin P. Howden, Timothy P. Stinear
  • Circulation of Plasmids Harboring Resistance Genes to Quinolones and/or Extended-Spectrum Cephalosporins in Multiple <em>Salmonella enterica</em> Serotypes from Swine in the United States
    Mechanisms of Resistance
    Circulation of Plasmids Harboring Resistance Genes to Quinolones and/or Extended-Spectrum Cephalosporins in Multiple Salmonella enterica Serotypes from Swine in the United States

    Nontyphoidal Salmonella enterica (NTS) poses a major public health risk worldwide that is amplified by the existence of antimicrobial-resistant strains, especially those resistant to quinolones and extended-spectrum cephalosporins (ESC). Little is known on the dissemination of plasmids harboring the acquired genetic determinants that confer resistance to these...

    Ehud Elnekave, Samuel L. Hong, Seunghyun Lim, Shivdeep S. Hayer, Dave Boxrud, Angela J. Taylor, Victoria Lappi, Noelle Noyes, Timothy J. Johnson, Albert Rovira, Peter Davies, Andres Perez, Julio Alvarez
  • Updated Prevalence of <em>mcr</em>-Like Genes among <em>Escherichia coli</em> and <em>Klebsiella pneumoniae</em> in the SENTRY Program and Characterization of <em>mcr-1.11</em> Variant
    Letter to the Editor
    Updated Prevalence of mcr-Like Genes among Escherichia coli and Klebsiella pneumoniae in the SENTRY Program and Characterization of mcr-1.11 Variant
    Lalitagauri M. Deshpande, Cory Hubler, Andrew P. Davis, Mariana Castanheira

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