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Plasmodium berghei

  • Open Access
    <em>In Vivo</em> Efficacy and Metabolism of the Antimalarial Cycleanine and Improved <em>In Vitro</em> Antiplasmodial Activity of Semisynthetic Analogues
    Pharmacology
    In Vivo Efficacy and Metabolism of the Antimalarial Cycleanine and Improved In Vitro Antiplasmodial Activity of Semisynthetic Analogues

    Bisbenzylisoquinoline (BBIQ) alkaloids are a diverse group of natural products that demonstrate a range of biological activities. In this study, the in vitro antiplasmodial activity of three BBIQ alkaloids (cycleanine [compound 1], isochondodendrine [compound 2], and 2′-norcocsuline [compound 3]) isolated from the Triclisia subcordata Oliv. medicinal plant...

    Fidelia Ijeoma Uche, Xiaozhen Guo, Jude Okokon, Imran Ullah, Paul Horrocks, Joshua Boateng, Chenggang Huang, Wen-Wu Li
  • Open Access
    Experimentally Engineered Mutations in a Ubiquitin Hydrolase, UBP-1, Modulate <em>In Vivo</em> Susceptibility to Artemisinin and Chloroquine in <span class="named-content genus-species" id="named-content-1">Plasmodium berghei</span>
    Mechanisms of Resistance
    Experimentally Engineered Mutations in a Ubiquitin Hydrolase, UBP-1, Modulate In Vivo Susceptibility to Artemisinin and Chloroquine in Plasmodium berghei

    As resistance to artemisinins (current frontline drugs in malaria treatment) emerges in Southeast Asia, there is an urgent need to identify the genetic determinants and understand the molecular mechanisms underpinning such resistance. Such insights could lead to prospective interventions to contain resistance and prevent the eventual spread to other regions where malaria is endemic. Reduced susceptibility to artemisinin in Southeast...

    Nelson V. Simwela, Katie R. Hughes, A. Brett Roberts, Michael T. Rennie, Michael P. Barrett, Andrew P. Waters
  • Mechanisms of Resistance
    Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome b That Are Transmissible through Mosquitoes
    Lynn D. Blake, Myles E. Johnson, Sasha V. Siegel, Adonis McQueen, Iredia D. Iyamu, Abdul Kadar Shaikh, Michael W. Shultis, Roman Manetsch, Dennis E. Kyle
  • Open Access
    Pharmacology
    Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds
    Raquel Azevedo, Marija Markovic, Marta Machado, Blandine Franke-Fayard, António M. Mendes, Miguel Prudêncio
  • Mechanisms of Resistance
    Within-Host Selection of Drug Resistance in a Mouse Model Reveals Dose-Dependent Selection of Atovaquone Resistance Mutations
    Suci Nuralitha, Lydia S. Murdiyarso, Josephine E. Siregar, Din Syafruddin, Jessica Roelands, Jan Verhoef, Andy I. M. Hoepelman, Sangkot Marzuki
  • Experimental Therapeutics
    Lipophilic Bisphosphonates Are Potent Inhibitors of Plasmodium Liver-Stage Growth
    Agam Prasad Singh, Yonghui Zhang, Joo-Hwan No, Roberto Docampo, Victor Nussenzweig, Eric Oldfield
  • Experimental Therapeutics
    Piperaquine Pharmacodynamics and Parasite Viability in a Murine Malaria Model
    Brioni R. Moore, Kenneth F. Ilett, Madhu Page-Sharp, Jeffrey D. Jago, Kevin T. Batty
  • Susceptibility
    Novel Inhibitor of Plasmodium Histone Deacetylase That Cures P. berghei-Infected Mice
    S. Agbor-Enoh, C. Seudieu, E. Davidson, A. Dritschilo, M. Jung
  • Experimental Therapeutics
    Antimalarial Activity of a New Stilbene Glycoside from Parthenocissus tricuspidata in Mice
    Won-Hwan Park, Sung-Jae Lee, Hyung-In Moon
  • Susceptibility
    Antiparasitic Activities and Toxicities of Individual Enantiomers of the 8-Aminoquinoline 8-[(4-Amino-1-Methylbutyl)Amino]-6-Methoxy-4-Methyl-5-[3,4-Dichlorophenoxy]Quinoline Succinate
    N. P. Dhammika Nanayakkara, Arba L. Ager, Marilyn S. Bartlett, Vanessa Yardley, Simon L. Croft, Ikhlas A. Khan, James D. McChesney, Larry A. Walker

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