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Plasmodium vivax

  • Influence of <em>CYP2C8</em>, <em>CYP3A4</em>, and <em>CYP3A5</em> Host Genotypes on Early Recurrence of <span class="named-content genus-species" id="named-content-1">Plasmodium vivax</span>
    Mechanisms of Resistance
    Influence of CYP2C8, CYP3A4, and CYP3A5 Host Genotypes on Early Recurrence of Plasmodium vivax

    Cytochrome P450 (CYP) enzymes are involved in the biotransformation of chloroquine (CQ), but the role of the different profiles of metabolism of this drug in relation to Plasmodium vivax recurrences has not been properly investigated. To investigate the influence of the CYP genotypes associated with CQ metabolism on the rates of...

    Anne C. G. Almeida, Maria C. B. Puça, Erick F. G. Figueiredo, Laila R. Barbosa, Yanka E. A. R. Salazar, Emanuelle L. Silva, Marcelo A. M. Brito, André M. Siqueira, José L. F. Vieira, Marcus V. G. Lacerda, Wuelton M. Monteiro, Gisely C. Melo
  • Novel Insights into <span class="named-content genus-species" id="named-content-1">Plasmodium vivax</span> Therapeutic Failure: CYP2D6 Activity and Time of Exposure to Malaria Modulate the Risk of Recurrence
    Epidemiology and Surveillance
    Novel Insights into Plasmodium vivax Therapeutic Failure: CYP2D6 Activity and Time of Exposure to Malaria Modulate the Risk of Recurrence

    Plasmodium vivax relapse is one of the major causes of sustained global malaria transmission. Primaquine (PQ) is the only commercial drug available to prevent relapses, and its efficacy is dependent on metabolic activation by cytochrome P450 2D6 (CYP2D6). Impaired CYP2D6 function, caused by allelic polymorphisms, leads to the therapeutic failure of PQ as a radical...

    Ana Carolina Rios Silvino, Flora Satiko Kano, Marcelo Azevedo Costa, Cor Jesus Fernandes Fontes, Irene Silva Soares, Cristiana Ferreira Alves de Brito, Luzia Helena Carvalho, Tais Nobrega Sousa
  • <em>In Vivo</em> Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the <em>Aotus</em> Monkey-Human Malaria Model
    Susceptibility
    In Vivo Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Aotus Monkey-Human Malaria Model

    Nonimmune Aotus monkeys infected with Plasmodium falciparum and Plasmodium vivax were cured of their infections when treated with a single oral dose of 5 mg/kg and 10 mg/kg of the 2-aminomethylphenol, JPC-3210, respectively. Corresponding mean blood elimination half-lives of JPC-3210 were...

    Fiona J. McCallum, Geoffrey W. Birrell, Marina Chavchich, Ivor Harris, Nicanor Obaldia, Karin Van Breda, Gavin D. Heffernan, David P. Jacobus, Dennis Shanks, Michael D. Edstein
  • Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for the Treatment of Malaria in Western Cambodia
    Clinical Therapeutics
    Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for the Treatment of Malaria in Western Cambodia

    This single-arm trial (n = 104) in western Cambodia showed high efficacy for 3-day treatment with pyronaridine-artesunate plus single-dose primaquine in Plasmodium falciparum malaria.

    Rithea Leang, Nimol Khim, Huch Chea, Rekol Huy, Melissa Mairet-Khedim, Denis Mey Bouth, Maria Dorina Bustos, Pascal Ringwald, Benoit Witkowski
  • Evolution and Genetic Diversity of the <em>k13</em> Gene Associated with Artemisinin Delayed Parasite Clearance in <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span>
    Epidemiology and Surveillance
    Evolution and Genetic Diversity of the k13 Gene Associated with Artemisinin Delayed Parasite Clearance in Plasmodium falciparum

    Mutations in the Plasmodium falciparum k13 (Pfk13) gene are linked to delayed parasite clearance in response to artemisinin-based combination therapies (ACTs) in Southeast Asia. To explore the evolutionary rate and constraints acting on this gene, k13 orthologs from species sharing a recent common ancestor with...

    M. Andreína Pacheco, Esha R. Kadakia, Zainab Chaudhary, Douglas J. Perkins, Julia Kelley, Shashidhar Ravishankar, Michael Cranfield, Eldin Talundzic, Venkatachalam Udhayakumar, Ananias A. Escalante
  • Monitoring the Efficacy of Chloroquine-Primaquine Therapy for Uncomplicated <span class="named-content genus-species" id="named-content-1">Plasmodium vivax</span> Malaria in the Main Transmission Hot Spot of Brazil
    Epidemiology and Surveillance
    Monitoring the Efficacy of Chloroquine-Primaquine Therapy for Uncomplicated Plasmodium vivax Malaria in the Main Transmission Hot Spot of Brazil

    Emerging Plasmodium vivax resistance to chloroquine (CQ) may undermine malaria elimination efforts in South America. CQ-resistant P. vivax has been found in the major port city of Manaus but not in the main malaria hot spots across the Amazon Basin of Brazil, where CQ is routinely coadministered...

    Simone Ladeia-Andrade, Maria José Menezes, Taís Nóbrega de Sousa, Ana Carolina R. Silvino, Jaques F. de Carvalho, Laís C. Salla, Odaílton A. Nery, Gladson N. P. de Melo, Rodrigo M. Corder, Priscila T. Rodrigues, Marcelo U. Ferreira
  • Experimental Therapeutics
    Reversal of Chloroquine Resistance of Plasmodium vivax in Aotus Monkeys

    Chloroquine-resistant (CQR) vivax malaria has emerged as a threat to the malaria elimination agenda. The objective of this study was to assess if a combination of chloroquine (CQ) and prochlorperazine was able to reverse CQ resistance of the Plasmodium vivax AMRU-1 strain from Papua New Guinea in infected ...

    Nicanor Obaldia, Wilbur K. Milhous, Dennis E. Kyle
  • Susceptibility
    Enhanced Ex Vivo Plasmodium vivax Intraerythrocytic Enrichment and Maturation for Rapid and Sensitive Parasite Growth Assays
    Gabriel W. Rangel, Martha A. Clark, Usheer Kanjee, Caeul Lim, Kathryn Shaw-Saliba, Maria José Menezes, Anjali Mascarenhas, Laura Chery, Edwin Gomes, Pradipsinh K. Rathod, Marcelo U. Ferreira, Manoj T. Duraisingh
  • Open Access
    Susceptibility
    Plasmodium falciparum and Plasmodium vivax Demonstrate Contrasting Chloroquine Resistance Reversal Phenotypes
    Grennady Wirjanata, Irene Handayuni, Pak Prayoga, Leo Leonardo, Dwi Apriyanti, Leily Trianty, Ruland Wandosa, Basbak Gobay, Enny Kenangalem, Jeanne Rini Poespoprodjo, Rintis Noviyanti, Dennis E. Kyle, Qin Cheng, Ric N. Price, Jutta Marfurt
  • Susceptibility
    In Vitro Activity of Pyronaridine against Multidrug-Resistant Plasmodium falciparum and Plasmodium vivax
    R. N. Price, J. Marfurt, F. Chalfein, E. Kenangalem, K. A. Piera, E. Tjitra, N. M. Anstey, B. Russell

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