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Pneumocystis

  • Site-Directed Mutagenesis of the 1,3-β-Glucan Synthase Catalytic Subunit of <em>Pneumocystis jirovecii</em> and Susceptibility Assays Suggest Its Sensitivity to Caspofungin
    Susceptibility
    Site-Directed Mutagenesis of the 1,3-β-Glucan Synthase Catalytic Subunit of Pneumocystis jirovecii and Susceptibility Assays Suggest Its Sensitivity to Caspofungin

    The echinocandin caspofungin inhibits the catalytic subunit Gsc1 of the enzymatic complex synthesizing 1,3-β-glucan, an essential compound of the fungal wall. Studies with rodents showed that caspofungin is effective against Pneumocystis asci.

    A. Luraschi, S. Richard, P. M. Hauser
  • Chloroquine Analogues as Leads against <span class="named-content genus-species" id="named-content-1">Pneumocystis</span> Lung Pathogens
    Susceptibility
    Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens

    The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP...

    Ana Gomes, Ricardo Ferraz, Lauren Ficker, Margaret S. Collins, Cristina Prudêncio, Melanie T. Cushion, Cátia Teixeira, Paula Gomes
  • Letter to the Editor
    The Fascinating Echinocandin-Treated Mouse Model of Pneumocystis murina To Understand Pneumocystis jirovecii
    Gilles Nevez, Anne Totet, Céline Damiani, Solène Le Gal
  • Open Access
    Mechanisms of Action: Physiological Effects
    Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction, Cell Wall Integrity, and Cell Cycle Arrest, Indicating a Requirement for Ascus Formation for Proliferation
    Melanie T. Cushion, Alan Ashbaugh, Keeley Hendrix, Michael J. Linke, Nikeya Tisdale, Steven G. Sayson, Aleksey Porollo
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Print ISSN: 0066-4804; Online ISSN: 1098-6596