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Pneumocystis

  • Open Access
    <em>In Vitro</em> Activity of a Novel Antifungal Compound, MYC-053, against Clinically Significant Antifungal-Resistant Strains of <em>Candida glabrata</em>, <em>Candida auris</em>, <em>Cryptococcus neoformans</em>, and <em>Pneumocystis</em> spp.
    Experimental Therapeutics
    In Vitro Activity of a Novel Antifungal Compound, MYC-053, against Clinically Significant Antifungal-Resistant Strains of Candida glabrata, Candida auris, Cryptococcus neoformans, and Pneumocystis spp.

    An urgent need exists for new antifungal compounds to treat fungal infections in immunocompromised patients. The aim of the current study was to investigate the potency of a novel antifungal compound, MYC-053, against the emerging yeast and yeast-like pathogens Candida glabrata, Candida auris,...

    G. Tetz, M. Collins, D. Vikina, V. Tetz
  • Site-Directed Mutagenesis of the 1,3-β-Glucan Synthase Catalytic Subunit of <em>Pneumocystis jirovecii</em> and Susceptibility Assays Suggest Its Sensitivity to Caspofungin
    Susceptibility
    Site-Directed Mutagenesis of the 1,3-β-Glucan Synthase Catalytic Subunit of Pneumocystis jirovecii and Susceptibility Assays Suggest Its Sensitivity to Caspofungin

    The echinocandin caspofungin inhibits the catalytic subunit Gsc1 of the enzymatic complex synthesizing 1,3-β-glucan, an essential compound of the fungal wall. Studies with rodents showed that caspofungin is effective against Pneumocystis asci.

    A. Luraschi, S. Richard, P. M. Hauser
  • Chloroquine Analogues as Leads against <span class="named-content genus-species" id="named-content-1">Pneumocystis</span> Lung Pathogens
    Susceptibility
    Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens

    The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP...

    Ana Gomes, Ricardo Ferraz, Lauren Ficker, Margaret S. Collins, Cristina Prudêncio, Melanie T. Cushion, Cátia Teixeira, Paula Gomes
  • Letter to the Editor
    The Fascinating Echinocandin-Treated Mouse Model of Pneumocystis murina To Understand Pneumocystis jirovecii
    Gilles Nevez, Anne Totet, Céline Damiani, Solène Le Gal
  • Open Access
    Mechanisms of Action: Physiological Effects
    Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction, Cell Wall Integrity, and Cell Cycle Arrest, Indicating a Requirement for Ascus Formation for Proliferation
    Melanie T. Cushion, Alan Ashbaugh, Keeley Hendrix, Michael J. Linke, Nikeya Tisdale, Steven G. Sayson, Aleksey Porollo
  • Experimental Therapeutics
    Mechanisms of Action of Vitamin D as Supplemental Therapy for Pneumocystis Pneumonia
    Guang-Sheng Lei, Chen Zhang, Bi-Hua Cheng, Chao-Hung Lee
  • Mechanisms of Resistance
    Mutations in the Pneumocystis jirovecii DHPS Gene Confer Cross-Resistance to Sulfa Drugs
    Peter Iliades, Steven R. Meshnick, Ian G. Macreadie
  • Mechanisms of Resistance
    Mutations of Pneumocystis jirovecii Dihydrofolate Reductase Associated with Failure of Prophylaxis
    Aimable Nahimana, Meja Rabodonirina, Jacques Bille, Patrick Francioli, Philippe M. Hauser
  • Mechanisms of Resistance
    Genotypes of Pneumocystis jiroveci Isolates Obtained in Harare, Zimbabwe, and London, United Kingdom
    Robert F. Miller, Austin R. Lindley, Helen E. Ambrose, Adam S. Malin, Ann E. Wakefield
  • Mechanisms of Resistance
    Recapitulation in Saccharomyces cerevisiae of Cytochrome b Mutations Conferring Resistance to Atovaquone in Pneumocystis jiroveci
    Philip Hill, Jacques Kessl, Nicholas Fisher, Steven Meshnick, Bernard L. Trumpower, Brigitte Meunier

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