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Pyrimidines

  • Open Access
    Antiviral Agents
    Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response
    Marianne Lucas-Hourani, Daniel Dauzonne, Hélène Munier-Lehmann, Samira Khiar, Sébastien Nisole, Julien Dairou, Olivier Helynck, Philippe V. Afonso, Frédéric Tangy, Pierre-Olivier Vidalain
  • Antiviral Agents
    In Vitro Cross-Resistance Profiles of Rilpivirine, Dapivirine, and MIV-150, Nonnucleoside Reverse Transcriptase Inhibitor Microbicides in Clinical Development for the Prevention of HIV-1 Infection
    Nicholas S. Giacobbi, Nicolas Sluis-Cremer
  • Experimental Therapeutics
    Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites
    Joachim Müller, Adriana Aguado-Martínez, Vreni Balmer, Dustin J. Maly, Erkang Fan, Luis-Miguel Ortega-Mora, Kayode K. Ojo, Wesley C. Van Voorhis, Andrew Hemphill
  • Antiviral Agents
    Frequent Cross-Resistance to Dapivirine in HIV-1 Subtype C-Infected Individuals after First-Line Antiretroviral Therapy Failure in South Africa
    Kerri J. Penrose, Carole L. Wallis, Chanson J. Brumme, Kristen A. Hamanishi, Kelley C. Gordon, Raquel V. Viana, P. Richard Harrigan, John W. Mellors, Urvi M. Parikh
  • Experimental Therapeutics
    Impact of cyp51A Mutations on the Pharmacokinetic and Pharmacodynamic Properties of Voriconazole in a Murine Model of Disseminated Aspergillosis
    Eleftheria Mavridou, Roger J. M. Bruggemann, Willem J. G. Melchers, Paul E. Verweij, Johan W. Mouton
  • Mechanisms of Action: Physiological Effects
    Discovery and Analysis of 4H-Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors
    Wendy Ribble, Walter E. Hill, Urs A. Ochsner, Thale C. Jarvis, Joseph W. Guiles, Nebojsa Janjic, James M. Bullard
  • Pharmacology
    Bioavailability and Population Pharmacokinetics of Voriconazole in Lung Transplant Recipients
    K. Han, B. Capitano, R. Bies, B. A. Potoski, S. Husain, S. Gilbert, D. L. Paterson, K. McCurry, R. Venkataramanan
  • Clinical Therapeutics
    International Retrospective Analysis of 73 Cases of Invasive Fusariosis Treated with Voriconazole
    Olivier Lortholary, Gaelle Obenga, Pinaki Biswas, Denis Caillot, Elisabeth Chachaty, Anne-Lise Bienvenu, Muriel Cornet, John Greene, Raoul Herbrecht, Claire Lacroix, Frédéric Grenouillet, Issam Raad, Karine Sitbon, Peter Troke
    and and the French Mycoses Study Group
  • Experimental Therapeutics
    Antifungal Therapy in a Murine Model of Disseminated Infection by Cryptococcus gattii
    Enrique Calvo, F. Javier Pastor, M. Mar Rodríguez, Isabel Pujol, Josep Guarro
  • Pharmacology
    Pharmacokinetics, Safety, and Tolerability of Voriconazole in Immunocompromised Children
    Thomas J. Walsh, Timothy Driscoll, Peter A. Milligan, Nolan D. Wood, Haran Schlamm, Andreas H. Groll, Hasan Jafri, Antonio C. Arrieta, Nigel J. Klein, Irja Lutsar

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