Pyrimidines

Open Access

Antiviral Agents
Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response
Marianne Lucas-Hourani, Daniel Dauzonne, Hélène Munier-Lehmann, Samira Khiar, Sébastien Nisole, Julien Dairou, Olivier Helynck, Philippe V. Afonso, Frédéric Tangy, Pierre-Olivier Vidalain
Antiviral Agents
In Vitro Cross-Resistance Profiles of Rilpivirine, Dapivirine, and MIV-150, Nonnucleoside Reverse Transcriptase Inhibitor Microbicides in Clinical Development for the Prevention of HIV-1 Infection
Nicholas S. Giacobbi, Nicolas Sluis-Cremer
Experimental Therapeutics
Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites
Joachim Müller, Adriana Aguado-Martínez, Vreni Balmer, Dustin J. Maly, Erkang Fan, Luis-Miguel Ortega-Mora, Kayode K. Ojo, Wesley C. Van Voorhis, Andrew Hemphill
Antiviral Agents
Frequent Cross-Resistance to Dapivirine in HIV-1 Subtype C-Infected Individuals after First-Line Antiretroviral Therapy Failure in South Africa
Kerri J. Penrose, Carole L. Wallis, Chanson J. Brumme, Kristen A. Hamanishi, Kelley C. Gordon, Raquel V. Viana, P. Richard Harrigan, John W. Mellors, Urvi M. Parikh
Experimental Therapeutics
Impact of cyp51A Mutations on the Pharmacokinetic and Pharmacodynamic Properties of Voriconazole in a Murine Model of Disseminated Aspergillosis
Eleftheria Mavridou, Roger J. M. Bruggemann, Willem J. G. Melchers, Paul E. Verweij, Johan W. Mouton
Mechanisms of Action: Physiological Effects
Discovery and Analysis of 4H-Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors
Wendy Ribble, Walter E. Hill, Urs A. Ochsner, Thale C. Jarvis, Joseph W. Guiles, Nebojsa Janjic, James M. Bullard
Pharmacology
Bioavailability and Population Pharmacokinetics of Voriconazole in Lung Transplant Recipients
K. Han, B. Capitano, R. Bies, B. A. Potoski, S. Husain, S. Gilbert, D. L. Paterson, K. McCurry, R. Venkataramanan
Clinical Therapeutics
International Retrospective Analysis of 73 Cases of Invasive Fusariosis Treated with Voriconazole
Olivier Lortholary, Gaelle Obenga, Pinaki Biswas, Denis Caillot, Elisabeth Chachaty, Anne-Lise Bienvenu, Muriel Cornet, John Greene, Raoul Herbrecht, Claire Lacroix, Frédéric Grenouillet, Issam Raad, Karine Sitbon, Peter Troke
and and the French Mycoses Study Group
Experimental Therapeutics
Antifungal Therapy in a Murine Model of Disseminated Infection by Cryptococcus gattii
Enrique Calvo, F. Javier Pastor, M. Mar Rodríguez, Isabel Pujol, Josep Guarro
Pharmacology
Pharmacokinetics, Safety, and Tolerability of Voriconazole in Immunocompromised Children
Thomas J. Walsh, Timothy Driscoll, Peter A. Milligan, Nolan D. Wood, Haran Schlamm, Andreas H. Groll, Hasan Jafri, Antonio C. Arrieta, Nigel J. Klein, Irja Lutsar

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Pyrimidines

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