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quinazolines

  • Quinazoline-Based Antivirulence Compounds Selectively Target <em>Salmonella</em> PhoP/PhoQ Signal Transduction System
    Biologic Response Modifiers
    Quinazoline-Based Antivirulence Compounds Selectively Target Salmonella PhoP/PhoQ Signal Transduction System

    The rapid emergence of multidrug resistance among bacterial pathogens has become a significant challenge to human health in our century. Therefore, development of next-generation antibacterial compounds is an urgent need. Two-component signal transduction systems (TCS) are stimulus-response coupling devices that allow bacteria to sense and elaborate adaptive responses to changing environmental conditions, including the challenges that...

    María Ayelén Carabajal, Christopher R. M. Asquith, Tuomo Laitinen, Graham J. Tizzard, Lucía Yim, Analía Rial, José A. Chabalgoity, William J. Zuercher, Eleonora García Véscovi
  • Chemistry; Biosynthesis
    Characterizing the Antimicrobial Activity of N2,N4-Disubstituted Quinazoline-2,4-Diamines toward Multidrug-Resistant Acinetobacter baumannii
    Renee Fleeman, Kurt S. Van Horn, Megan M. Barber, Whittney N. Burda, David L. Flanigan, Roman Manetsch, Lindsey N. Shaw
  • Mechanisms of Action: Physiological Effects
    Novel Effects of Lapatinib Revealed in the African Trypanosome by Using Hypothesis-Generating Proteomics and Chemical Biology Strategies
    Paul J. Guyett, Ranjan Behera, Yuko Ogata, Michael Pollastri, Kojo Mensa-Wilmot
  • Pharmacology
    Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N′6′-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate
    Alexis Nzila, Matthias Rottmann, Penchit Chitnumsub, Stevens M. Kiara, Sumalee Kamchonwongpaisan, Cherdsak Maneeruttanarungroj, Supannee Taweechai, Bryan K. S. Yeung, Anne Goh, Suresh B. Lakshminarayana, Bin Zou, Josephine Wong, Ngai Ling Ma, Margaret Weaver, Thomas H. Keller, Veronique Dartois, Sergio Wittlin, Reto Brun, Yongyuth Yuthavong, Thierry T. Diagana
  • Antiviral Agents
    InVitro and In Vivo Activities of the Novel Anticytomegalovirus Compound AIC246
    Peter Lischka, Guy Hewlett, Tobias Wunberg, Judith Baumeister, Daniela Paulsen, Thomas Goldner, Helga Ruebsamen-Schaeff, Holger Zimmermann
  • Experimental Therapeutics
    Efficacy of Albaconazole against Candida albicans in a Vaginitis Model
    Gloria M. González, Efrén Robledo, Elvira Garza-González, Mariana Elizondo, J. Gerardo González
  • Susceptibility
    Inhibition of Toxoplasma gondii by Indirubin and Tryptanthrin Analogs
    Bogdana Krivogorsky, Peter Grundt, Robert Yolken, Lorraine Jones-Brando
  • Mechanisms of Action: Physiological Effects
    Anaerobic NADH-Fumarate Reductase System Is Predominant in the Respiratory Chain of Echinococcus multilocularis, Providing a Novel Target for the Chemotherapy of Alveolar Echinococcosis
    Jun Matsumoto, Kimitoshi Sakamoto, Noriko Shinjyo, Yasutoshi Kido, Nao Yamamoto, Kinpei Yagi, Hideto Miyoshi, Nariaki Nonaka, Ken Katakura, Kiyoshi Kita, Yuzaburo Oku
  • Pharmacology
    Pharmacokinetics, Safety, and Hydrolysis of Oral Pyrroloquinazolinediamines Administered in Single and Multiple Doses in Rats
    Qigui Li, Michael P. Kozar, Todd W. Shearer, Lisa H. Xie, Ai J. Lin, Kirsten S. Smith, Yuanzheng Si, Lalaine Anova, Jing Zhang, Wilbur K. Milhous, Donald R. Skillman
  • Experimental Therapeutics
    New Potential Antimalarial Agents: Therapeutic-Index Evaluation of Pyrroloquinazolinediamine and Its Prodrugs in a Rat Model of Severe Malaria
    Lisa H. Xie, Qigui Li, Ai J. Lin, Kirsten Smith, Jing Zhang, Donald S. Skillman

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