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quinolones

  • Cold Shock Induces Chromosomal <em>qnr</em> in <em>Vibrio</em> Species and Plasmid-Mediated <em>qnrS1</em> in <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Mechanisms of Resistance
    Cold Shock Induces Chromosomal qnr in Vibrio Species and Plasmid-Mediated qnrS1 in Escherichia coli

    qnr genes are found in aquatic bacteria and were present in the bacterial community before the introduction of synthetic quinolones. Their natural functions are unknown. We evaluated expression of chromosomal qnr in Vibrio species in response to environmental stresses and DNA-damaging agents. Subinhibitory concentrations of quinolones, but not other DNA-damaging agents, increased expression of chromosomal ...

    Hee-Chang Jang, Yin Wang, Chunhui Chen, Laura Vinué, George A. Jacoby, David C. Hooper
  • Novel Quinolone Resistance Determinant, <em>qepA8</em>, in <span class="named-content genus-species" id="named-content-1">Shigella flexneri</span> Isolated in the United States in 2016
    Letter to the Editor
    Novel Quinolone Resistance Determinant, qepA8, in Shigella flexneri Isolated in the United States in 2016
    Hattie E. Webb, Kaitlin A. Tagg, Jessica C. Chen, Justin Kim, Rebecca Lindsey, Louise K. Francois Watkins, Beth E. Karp, Yo Sugawara, Jason P. Folster
  • <em>In Vitro</em> Activity of Levonadifloxacin (WCK 771) against <span class="named-content genus-species" id="named-content-1">Chlamydia pneumoniae</span>
    Letter to the Editor
    In Vitro Activity of Levonadifloxacin (WCK 771) against Chlamydia pneumoniae
    Stephan Kohlhoff, Natalia Huerta, Margaret R. Hammerschlag
  • <em>In Vitro</em> Mechanistic Study of the Distribution of Lascufloxacin into Epithelial Lining Fluid
    Pharmacology
    In Vitro Mechanistic Study of the Distribution of Lascufloxacin into Epithelial Lining Fluid

    The present study aimed to clarify the mechanism underlying the high distribution of lascufloxacin in epithelial lining fluid (ELF). Involvement of transporters was examined by transcellular transport across Calu-3 and transporter-overexpressing cells; the binding of lascufloxacin to ELF components was examined by an organic solvent-water partitioning system that employed pulmonary surfactant and phospholipids.

    Kouhei Ohya, Junichi Takano, Shigeru Manita
  • Emergence of Resistance to Quinolones and β-Lactam Antibiotics in Enteroaggregative and Enterotoxigenic <em>Escherichia coli</em> Causing Traveler’s Diarrhea
    Epidemiology and Surveillance
    Emergence of Resistance to Quinolones and β-Lactam Antibiotics in Enteroaggregative and Enterotoxigenic Escherichia coli Causing Traveler’s Diarrhea

    The objective of this study was to assess the antimicrobial resistance of enteroaggregative Escherichia coli (EAEC) and enterotoxigenic E. coli (ETEC) strains causing traveler’s diarrhea (TD) and to investigate the molecular characterization of antimicrobial resistance genes to third-generation...

    Elisabet Guiral, Milene Gonçalves Quiles, Laura Muñoz, Javier Moreno-Morales, Izaskun Alejo-Cancho, Pilar Salvador, Miriam J. Alvarez-Martinez, Francesc Marco, Jordi Vila
  • Mechanisms of Resistance
    Functional Characterization of AbaQ, a Novel Efflux Pump Mediating Quinolone Resistance in Acinetobacter baumannii

    Acinetobacter baumannii has emerged as an important multidrug-resistant nosocomial pathogen. In previous work, we identified a putative MFS transporter, AU097_RS17040, involved in the pathogenicity of A. baumannii (M.

    María Pérez-Varela, Jordi Corral, Jesús Aranda, Jordi Barbé
  • Mechanisms of Resistance
    Genes and Proteins Involved in qnrS1 Induction

    Expression of the quinolone resistance gene qnrS1 is increased by quinolones, but unlike induction of some other qnr genes, the bacterial SOS system is not involved and no lexA box is found upstream. Nonetheless, at least 205 bp of upstream sequence is required for induction to take place.

    Rubén Monárrez, Yin Wang, Yingmei Fu, Chun-Hsing Liao, Ryo Okumura, Molly R. Braun, George A. Jacoby, David C. Hooper
  • Mechanisms of Resistance
    CrpP Is a Novel Ciprofloxacin-Modifying Enzyme Encoded by the Pseudomonas aeruginosa pUM505 Plasmid
    Víctor M. Chávez-Jacobo, Karen C. Hernández-Ramírez, Pamela Romo-Rodríguez, Rocío Viridiana Pérez-Gallardo, Jesús Campos-García, J. Félix Gutiérrez-Corona, Juan Pablo García-Merinos, Víctor Meza-Carmen, Jesús Silva-Sánchez, Martha I. Ramírez-Díaz
  • Pharmacology
    Intrapulmonary Pharmacokinetics of Lascufloxacin in Healthy Adult Volunteers
    Hidetoshi Furuie, Sayoko Tanioka, Keiko Shimizu, Shigeru Manita, Masaharu Nishimura, Hisao Yoshida
  • Susceptibility
    In Vitro Activity and MIC of Sitafloxacin against Multidrug-Resistant and Extensively Drug-Resistant Mycobacterium tuberculosis Isolated in Thailand
    Manoon Leechawengwongs, Therdsak Prammananan, Sarinya Jaitrong, Pamaree Billamas, Nampueng Makhao, Nongnard Thamnongdee, Arirat Thanormchat, Arisa Phurattanakornkul, Somcharn Rattanarangsee, Chate Ratanajaraya, Areeya Disratthakit, Angkana Chaiprasert

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