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replicon

  • Comparison of Commensal and Clinical Isolates for Diversity of Plasmids in <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> and <span class="named-content genus-species" id="named-content-2">Klebsiella pneumoniae</span>
    Epidemiology and Surveillance
    Comparison of Commensal and Clinical Isolates for Diversity of Plasmids in Escherichia coli and Klebsiella pneumoniae

    In this study, the plasmid content of clinical and commensal strains was analyzed and compared. The replicon profile was similar in both populations, except for L, M, A/C, and N (detected only in clinical strains) and HI1 (only in commensal strains). Although I1 and F were the most frequent replicons, only IncI1, sequence type 12 (ST12) was associated with blaCMY-2 in both populations. In contrast, the widespread...

    Judith Rodríguez-Navarro, Elisenda Miró, Maryury Brown-Jaque, Juan Carlos Hurtado, Albert Moreno, Maite Muniesa, Juan José González-López, Jordi Vila, Paula Espinal, Ferran Navarro
  • <em>In Silico</em> Typing and Comparative Genomic Analysis of IncFII<sub>K</sub> Plasmids and Insights into the Evolution of Replicons, Plasmid Backbones, and Resistance Determinant Profiles
    Mechanisms of Resistance
    In Silico Typing and Comparative Genomic Analysis of IncFIIK Plasmids and Insights into the Evolution of Replicons, Plasmid Backbones, and Resistance Determinant Profiles

    IncFIIK plasmids are associated with the acquisition and dissemination of multiple-antimicrobial resistance in Klebsiella pneumoniae and often encountered in clinical isolates of this species. Since the phylogeny and evolution of IncFIIK plasmids remain unclear, here we performed large-scale in silico typing and comparative analysis of...

    Dexi Bi, Jiayi Zheng, Jun-Jie Li, Zi-Ke Sheng, Xingchen Zhu, Hong-Yu Ou, Qianyu Li, Qing Wei
  • Antiviral Agents
    Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus
    Maryam Ehteshami, Sijia Tao, Keivan Zandi, Hui-Mien Hsiao, Yong Jiang, Emily Hammond, Franck Amblard, Olivia O. Russell, Andres Merits, Raymond F. Schinazi
  • Mechanisms of Resistance
    bla ROB-1 Presence on pB1000 in Haemophilus influenzae Is Widespread, and Variable Cefaclor Resistance Is Associated with Altered Penicillin-Binding Proteins
    Stephen G. Tristram, Rachael Littlejohn, Richard S. Bradbury
  • Mechanisms of Resistance
    Characterization and PCR-Based Replicon Typing of Resistance Plasmids in Acinetobacter baumannii
    Alessia Bertini, Laurent Poirel, Pauline D. Mugnier, Laura Villa, Patrice Nordmann, Alessandra Carattoli
  • Antiviral Agents
    Novel Hepatitis C Virus Reporter Replicon Cell Lines Enable Efficient Antiviral Screening against Genotype 1a
    Margaret Robinson, Huiling Yang, Siu-Chi Sun, Betty Peng, Yang Tian, Nikos Pagratis, Andrew E. Greenstein, William E. Delaney
  • Antiviral Agents
    Mechanism of Resistance of Hepatitis C Virus Replicons to Structurally Distinct Cyclophilin Inhibitors
    Xiaoling Puyang, Danielle L. Poulin, Joanna E. Mathy, Leah J. Anderson, Sue Ma, Zheng Fang, Shejin Zhu, Kai Lin, Roger Fujimoto, Teresa Compton, Brigitte Wiedmann
  • Antiviral Agents
    Identification of Inhibitors of Yellow Fever Virus Replication Using a Replicon-Based High-Throughput Assay
    Chinmay G. Patkar, Martha Larsen, Michael Owston, Janet L. Smith, Richard J. Kuhn
  • Antiviral Agents
    The Octadecyloxyethyl Ester of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy) Propyl]Adenine Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication in Genotype 1A, 1B, and 2A Replicons
    David L. Wyles, Kelly A. Kaihara, Brent E. Korba, Robert T. Schooley, James R. Beadle, Karl Y. Hostetler
  • Antiviral Agents
    Selection and Characterization of Hepatitis C Virus Replicons Dually Resistant to the Polymerase and Protease Inhibitors HCV-796 and Boceprevir (SCH 503034)
    Mike Flint, Stanley Mullen, Anne M. Deatly, Wei Chen, Lynn Z. Miller, Robert Ralston, Colin Broom, Emilio A. Emini, Anita Y. M. Howe

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