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respiratory tract infections

  • Pharmacology
    Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model
    Yu-Wei Lin, Qi Tony Zhou, Mei-Ling Han, Nikolas J. Onufrak, Ke Chen, Jiping Wang, Alan Forrest, Hak-Kim Chan, Jian Li
  • Pharmacology
    Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-Resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model
    Yu-Wei Lin, Qi Tony Zhou, Mei-Ling Han, Ke Chen, Nikolas J. Onufrak, Jiping Wang, John D. Turnidge, Benjamin P. Howden, Alan Forrest, Hak-Kim Chan, Jian Li
  • Pharmacology
    The Fluorocycline TP-271 Is Efficacious in Models of Aerosolized Bacillus anthracis Infection in BALB/c Mice and Cynomolgus Macaques
    Trudy H. Grossman, Michael S. Anderson, Lindsay Drabek, Melanie Gooldy, Henry S. Heine, Lisa N. Henning, Winston Lin, Joseph V. Newman, Rene Nevarez, Kaylyn Siefkas-Patterson, Anne K. Radcliff, Joyce A. Sutcliffe
  • Clinical Therapeutics
    Pharmacokinetic-Pharmacodynamic Target Attainment Analyses To Determine Optimal Dosing of Ceftazidime-Avibactam for the Treatment of Acute Pulmonary Exacerbations in Patients with Cystic Fibrosis
    Timothy J. Bensman, Joshua Wang, Jordanna Jayne, Lynn Fukushima, Adupa P. Rao, David Z. D'Argenio, Paul M. Beringer
  • Experimental Therapeutics
    Evaluation of Combination Drug Therapy for Treatment of Antibiotic-Resistant Inhalation Anthrax in a Murine Model
    H. S. Heine, S. V. Shadomy, A. E. Boyer, L. Chuvala, R. Riggins, A. Kesterson, J. Myrick, J. Craig, M. G. Candela, J. R. Barr, K. Hendricks, W. A. Bower, H. Walke, G. L. Drusano
  • Open Access
    Pharmacology
    Efficacy of Cefiderocol against Carbapenem-Resistant Gram-Negative Bacilli in Immunocompetent-Rat Respiratory Tract Infection Models Recreating Human Plasma Pharmacokinetics
    Shuhei Matsumoto, Christine M. Singley, Jennifer Hoover, Rio Nakamura, Roger Echols, Stephen Rittenhouse, Masakatsu Tsuji, Yoshinori Yamano
  • Experimental Therapeutics
    A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness
    Manon F. Pritchard, Lydia C. Powell, Alison A. Jack, Kate Powell, Konrad Beck, Hannah Florance, Julian Forton, Philip D. Rye, Arne Dessen, Katja E. Hill, David W. Thomas
  • Open Access
    Antiviral Agents
    Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor
    Matthew Coates, Daniel Brookes, Young-In Kim, Heather Allen, Euan A. F. Fordyce, Elizabeth A. Meals, Thomas Colley, Claire-Lise Ciana, Guillaume F. Parra, Vladimir Sherbukhin, Jennifer A. Stockwell, Jennifer C. Thomas, S. Fraser Hunt, Lauren Anderson-Dring, Stuart T. Onions, Lindsey Cass, Peter J. Murray, Kazuhiro Ito, Pete Strong, John P. DeVincenzo, Garth Rapeport
  • Pharmacology
    The Fluorocycline TP-271 Is Efficacious in Models of Aerosolized Francisella tularensis SCHU S4 Infection in BALB/c Mice and Cynomolgus Macaques
    Trudy H. Grossman, Michael S. Anderson, David Christ, Melanie Gooldy, Lisa N. Henning, Henry S. Heine, M. Victoria Kindt, Winston Lin, Kaylyn Siefkas-Patterson, Anne K. Radcliff, Vincent H. Tam, Joyce A. Sutcliffe
  • Pharmacology
    Aerosolized Polymyxin B for Treatment of Respiratory Tract Infections: Determination of Pharmacokinetic-Pharmacodynamic Indices for Aerosolized Polymyxin B against Pseudomonas aeruginosa in a Mouse Lung Infection Model
    Yu-Wei Lin, Qi Zhou, Nikolas J. Onufrak, Veronika Wirth, Ke Chen, Jiping Wang, Alan Forrest, Hak-Kim Chan, Jian Li

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