respiratory tract infections

Pharmacology
Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model
Yu-Wei Lin, Qi Tony Zhou, Mei-Ling Han, Nikolas J. Onufrak, Ke Chen, Jiping Wang, Alan Forrest, Hak-Kim Chan, Jian Li
Pharmacology
Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-Resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model
Yu-Wei Lin, Qi Tony Zhou, Mei-Ling Han, Ke Chen, Nikolas J. Onufrak, Jiping Wang, John D. Turnidge, Benjamin P. Howden, Alan Forrest, Hak-Kim Chan, Jian Li
Clinical Therapeutics
Pharmacokinetic-Pharmacodynamic Target Attainment Analyses To Determine Optimal Dosing of Ceftazidime-Avibactam for the Treatment of Acute Pulmonary Exacerbations in Patients with Cystic Fibrosis
Timothy J. Bensman, Joshua Wang, Jordanna Jayne, Lynn Fukushima, Adupa P. Rao, David Z. D'Argenio, Paul M. Beringer
Pharmacology
The Fluorocycline TP-271 Is Efficacious in Models of Aerosolized Bacillus anthracis Infection in BALB/c Mice and Cynomolgus Macaques
Trudy H. Grossman, Michael S. Anderson, Lindsay Drabek, Melanie Gooldy, Henry S. Heine, Lisa N. Henning, Winston Lin, Joseph V. Newman, Rene Nevarez, Kaylyn Siefkas-Patterson, Anne K. Radcliff, Joyce A. Sutcliffe
Experimental Therapeutics
Evaluation of Combination Drug Therapy for Treatment of Antibiotic-Resistant Inhalation Anthrax in a Murine Model
H. S. Heine, S. V. Shadomy, A. E. Boyer, L. Chuvala, R. Riggins, A. Kesterson, J. Myrick, J. Craig, M. G. Candela, J. R. Barr, K. Hendricks, W. A. Bower, H. Walke, G. L. Drusano
Open Access

Pharmacology
Efficacy of Cefiderocol against Carbapenem-Resistant Gram-Negative Bacilli in Immunocompetent-Rat Respiratory Tract Infection Models Recreating Human Plasma Pharmacokinetics
Shuhei Matsumoto, Christine M. Singley, Jennifer Hoover, Rio Nakamura, Roger Echols, Stephen Rittenhouse, Masakatsu Tsuji, Yoshinori Yamano
Experimental Therapeutics
A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness
Manon F. Pritchard, Lydia C. Powell, Alison A. Jack, Kate Powell, Konrad Beck, Hannah Florance, Julian Forton, Philip D. Rye, Arne Dessen, Katja E. Hill, David W. Thomas
Open Access

Antiviral Agents
Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor
Matthew Coates, Daniel Brookes, Young-In Kim, Heather Allen, Euan A. F. Fordyce, Elizabeth A. Meals, Thomas Colley, Claire-Lise Ciana, Guillaume F. Parra, Vladimir Sherbukhin, Jennifer A. Stockwell, Jennifer C. Thomas, S. Fraser Hunt, Lauren Anderson-Dring, Stuart T. Onions, Lindsey Cass, Peter J. Murray, Kazuhiro Ito, Pete Strong, John P. DeVincenzo, Garth Rapeport
Pharmacology
The Fluorocycline TP-271 Is Efficacious in Models of Aerosolized Francisella tularensis SCHU S4 Infection in BALB/c Mice and Cynomolgus Macaques
Trudy H. Grossman, Michael S. Anderson, David Christ, Melanie Gooldy, Lisa N. Henning, Henry S. Heine, M. Victoria Kindt, Winston Lin, Kaylyn Siefkas-Patterson, Anne K. Radcliff, Vincent H. Tam, Joyce A. Sutcliffe
Pharmacology
Aerosolized Polymyxin B for Treatment of Respiratory Tract Infections: Determination of Pharmacokinetic-Pharmacodynamic Indices for Aerosolized Polymyxin B against Pseudomonas aeruginosa in a Mouse Lung Infection Model
Yu-Wei Lin, Qi Zhou, Nikolas J. Onufrak, Veronika Wirth, Ke Chen, Jiping Wang, Alan Forrest, Hak-Kim Chan, Jian Li

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