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Saccharomyces cerevisiae

  • The Siderophore Transporter Sit1 Determines Susceptibility to the Antifungal VL-2397
    Susceptibility
    The Siderophore Transporter Sit1 Determines Susceptibility to the Antifungal VL-2397

    VL-2397 (previously termed ASP2397) is an antifungal, aluminum-chelating cyclic hexapeptide with a structure analogous to that of ferrichrome-type siderophores, whereby replacement of aluminum by iron was shown to decrease the antifungal activity of this compound. Here, we found that inactivation of an importer for ferrichrome-type siderophores, termed Sit1, renders ...

    Anna-Maria Dietl, Matthias Misslinger, Mario M. Aguiar, Vasyl Ivashov, David Teis, Joachim Pfister, Clemens Decristoforo, Martin Hermann, Sean M. Sullivan, Larry R. Smith, Hubertus Haas
  • Inhibition of Vesicular Transport Influences Fungal Susceptibility to Fluconazole
    Mechanisms of Resistance
    Inhibition of Vesicular Transport Influences Fungal Susceptibility to Fluconazole

    Fungal infections pose a substantial threat to the human population. They can cause either mild and relatively harmless infections or invasive and often lethal diseases in patients with a weakened immune system.

    Liesbeth Demuyser, Katrien Van Dyck, Bea Timmermans, Patrick Van Dijck
  • Vacuolar Sequestration of Azoles, a Novel Strategy of Azole Antifungal Resistance Conserved across Pathogenic and Nonpathogenic Yeast
    Mechanisms of Resistance
    Vacuolar Sequestration of Azoles, a Novel Strategy of Azole Antifungal Resistance Conserved across Pathogenic and Nonpathogenic Yeast

    Target alteration and overproduction and drug efflux through overexpression of multidrug transporters localized in the plasma membrane represent the conventional mechanisms of azole antifungal resistance. Here, we identify a novel conserved mechanism of azole resistance not only in the budding yeast Saccharomyces cerevisiae but also in the pathogenic yeast...

    Nitesh Kumar Khandelwal, Mohd Wasi, Remya Nair, Meghna Gupta, Mohit Kumar, Alok K. Mondal, Naseem A. Gaur, Rajendra Prasad
  • Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161
    Experimental Therapeutics
    Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161

    Tetrazole antifungals designed to target fungal lanosterol 14α-demethylase (LDM) appear to be effective against a range of fungal pathogens. In addition, a crystal structure of the catalytic domain of Candida albicans LDM in complex with the tetrazole VT-1161 has been obtained.

    Brian C. Monk, Mikhail V. Keniya, Manya Sabherwal, Rajni K. Wilson, Danyon O. Graham, Harith F. Hassan, Danni Chen, Joel D. A. Tyndall
  • Mechanisms of Resistance
    Molecular Confirmation of the Relationship between Candida guilliermondii Fks1p Naturally Occurring Amino Acid Substitutions and Its Intrinsic Reduced Echinocandin Susceptibility
    Catiana Dudiuk, Daiana Macedo, Florencia Leonardelli, Laura Theill, Matias S. Cabeza, Soledad Gamarra, Guillermo Garcia-Effron
  • Mechanisms of Action: Physiological Effects
    Fludioxonil Induces Drk1, a Fungal Group III Hybrid Histidine Kinase, To Dephosphorylate Its Downstream Target, Ypd1
    Stephanie M. Lawry, Brad Tebbets, Iain Kean, Douglas Stewart, Joel Hetelle, Bruce S. Klein
  • Mechanisms of Action: Physiological Effects
    Mechanism of Antifungal Activity of Terpenoid Phenols Resembles Calcium Stress and Inhibition of the TOR Pathway
    Anjana Rao, Yongqiang Zhang, Sabina Muend, Rajini Rao
  • Susceptibility
    Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14α-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B
    Claire M. Martel, Josie E. Parker, Andrew G. S. Warrilow, Nicola J. Rolley, Steven L. Kelly, Diane E. Kelly
  • Mechanisms of Action: Physiological Effects
    Natamycin Inhibits Vacuole Fusion at the Priming Phase via a Specific Interaction with Ergosterol
    Yvonne Maria te Welscher, Lynden Jones, Martin Richard van Leeuwen, Jan Dijksterhuis, Ben de Kruijff, Gary Eitzen, Eefjan Breukink
  • Mechanisms of Action: Physiological Effects
    Transcriptomic Profiling of the Saccharomyces cerevisiae Response to Quinine Reveals a Glucose Limitation Response Attributable to Drug-Induced Inhibition of Glucose Uptake
    Sandra C. dos Santos, Sandra Tenreiro, Margarida Palma, Jorg Becker, Isabel Sá-Correia

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