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Scedosporium

  • Olorofim Susceptibility Testing of 1,423 Danish Mold Isolates Obtained in 2018-2019 Confirms Uniform and Broad-Spectrum Activity
    Susceptibility
    Olorofim Susceptibility Testing of 1,423 Danish Mold Isolates Obtained in 2018-2019 Confirms Uniform and Broad-Spectrum Activity

    Olorofim is a novel antifungal drug in phase 2 trials. It has shown promising in vitro activity against various molds, except for Mucorales. Initially, we observed a broad range of EUCAST MICs for Aspergillus fumigatus. Here, we explored the MIC variability in more detail and prospectively investigated the susceptibility of contemporary clinical mold isolates...

    Karen Marie Thyssen Astvad, Karin Meinike Jørgensen, Rasmus Krøger Hare, Raluca Datcu, Maiken Cavling Arendrup
  • Open Access
    Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis
    Editor's Pick Experimental Therapeutics
    Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis

    There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium. Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. We evaluated the in vitro activity of MGX and the efficacy of the prodrug fosmanogepix (APX001)...

    Sondus Alkhazraji, Teclegiorgis Gebremariam, Abdullah Alqarihi, Yiyou Gu, Zeinab Mamouei, Shakti Singh, Nathan P. Wiederhold, Karen J. Shaw, Ashraf S. Ibrahim
  • Therapeutic Challenges of Non-<em>Aspergillus</em> Invasive Mold Infections in Immunosuppressed Patients
    Editor's Pick Minireview
    Therapeutic Challenges of Non-Aspergillus Invasive Mold Infections in Immunosuppressed Patients

    While Aspergillus spp. remain the major cause of invasive mold infections in hematologic cancer patients and transplant recipients, other opportunistic molds, such as Mucorales, Fusarium, and Scedosporium spp. are increasingly encountered in an expanding population of patients with severe and prolonged immunosuppression. High potential for tissue invasion and dissemination, resistance to multiple...

    Frederic Lamoth, Dimitrios P. Kontoyiannis
  • Susceptibility
    Molecular Identification and Susceptibility Testing of Molds Isolated in a Prospective Surveillance of Triazole Resistance in Spain (FILPOP2 Study)

    Antifungal resistance is increasing by the emergence of intrinsically resistant species and by the development of secondary resistance in susceptible species. A previous study performed in Spain revealed levels of azole resistance in molds of between 10 and 12.7%, but secondary resistance in Aspergillus fumigatus was not detected.

    Ana Alastruey-Izquierdo, Laura Alcazar-Fuoli, Olga Rivero-Menéndez, Josefina Ayats, Carmen Castro, Julio García-Rodríguez, Lidia Goterris-Bonet, Elisa Ibáñez-Martínez, María José Linares-Sicilia, M. Teresa Martin-Gomez, Estrella Martín-Mazuelos, Teresa Pelaez, Javier Peman, Antonio Rezusta, Susana Rojo, Rocio Tejero, Diego Vicente Anza, Jesús Viñuelas, Maria Soledad Zapico, Manuel Cuenca-Estrella
    and on behalf of the FILPOP2 Project from GEMICOMED (SEIMC) and REIPI
  • Experimental Therapeutics
    Experimental Murine Scedosporiosis: Histopathology and Azole Treatment
    M. Mar Rodríguez, F. Javier Pastor, Valentina Salas, Enrique Calvo, Emilio Mayayo, Josep Guarro
  • Experimental Therapeutics
    Effects of Double and Triple Combinations of Antifungal Drugs in a Murine Model of Disseminated Infection by Scedosporium prolificans
    M. Mar Rodríguez, Enrique Calvo, Carolina Serena, Marçal Mariné, F. Javier Pastor, Josep Guarro
  • Clinical Therapeutics
    Treatment of Scedosporiosis with Voriconazole: Clinical Experience with 107 Patients
    Peter Troke, Koldo Aguirrebengoa, Carmen Arteaga, David Ellis, Christopher H. Heath, Irja Lutsar, Montserrat Rovira, Quoc Nguyen, Monica Slavin, Sharon C. A. Chen
    and on behalf of the Global Scedosporium Study Group
  • Susceptibility
    In Vitro Activities of 35 Double Combinations of Antifungal Agents against Scedosporium apiospermum and Scedosporium prolificans
    Manuel Cuenca-Estrella, Ana Alastruey-Izquierdo, Laura Alcazar-Fuoli, Leticia Bernal-Martinez, Alicia Gomez-Lopez, Maria J. Buitrago, Emilia Mellado, Juan L. Rodriguez-Tudela
  • Susceptibility
    Prevalence and Susceptibility Testing of New Species of Pseudallescheria and Scedosporium in a Collection of Clinical Mold Isolates
    Ana Alastruey-Izquierdo, Manuel Cuenca-Estrella, Araceli Monzón, Juan L. Rodriguez-Tudela
  • Susceptibility
    Antifungal Susceptibilities of the Species of the Pseudallescheria boydii Complex
    Fèlix Gilgado, Carolina Serena, Josep Cano, Josepa Gené, Josep Guarro

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