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Staphylococcus

  • Open Access
    Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in <span class="named-content genus-species" id="named-content-1">Staphylococcus lugdunensis</span>
    Mechanisms of Resistance
    Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis

    Lugdunin is the first reported nonribosomally synthesized antibiotic from human microbiomes. Its production by the commensal Staphylococcus lugdunensis eliminates the pathogen Staphylococcus aureus from human nasal microbiomes. The cycloheptapeptide lugdunin is the founding member of the new class...

    Sophia Krauss, Alexander Zipperer, Sebastian Wirtz, Julian Saur, Martin C. Konnerth, Simon Heilbronner, Benjamin O. Torres Salazar, Stephanie Grond, Bernhard Krismer, Andreas Peschel
  • Free
    Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent <span class="named-content genus-species" id="named-content-1">Staphylococcus argenteus</span> Sepsis
    Editor's Pick Challenging Clinical Case in Antimicrobial Resistance
    Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent Staphylococcus argenteus Sepsis

    Staphylococcus argenteus is a novel staphylococcal species associated with invasive disease. We report the first case of daptomycin/vancomycin-resistant S. argenteus, initially speciated as Staphylococcus aureus, that developed...

    Samantha Hao, Mazin Abdelghany, Amy Lyden, Rene Sit, Michelle Tan, Cristina M. Tato, Joseph L. DeRisi, Steve Miller, Sarah B. Doernberg, Charles Langelier
  • Open Access
    Afabicin, a First-in-Class Antistaphylococcal Antibiotic, in the Treatment of Acute Bacterial Skin and Skin Structure Infections: Clinical Noninferiority to Vancomycin/Linezolid
    Clinical Therapeutics
    Afabicin, a First-in-Class Antistaphylococcal Antibiotic, in the Treatment of Acute Bacterial Skin and Skin Structure Infections: Clinical Noninferiority to Vancomycin/Linezolid

    Afabicin (formerly Debio 1450, AFN-1720) is a prodrug of afabicin desphosphono, an enoyl-acyl carrier protein reductase (FabI) inhibitor, and is a first-in-class antibiotic with a novel mode of action to specifically target fatty acid synthesis in Staphylococcus spp. The efficacy, safety, and tolerability of afabicin were compared with those of vancomycin/linezolid in the treatment of acute bacterial skin and skin structure...

    Frederick Wittke, Catherine Vincent, James Chen, Barry Heller, Heidi Kabler, J. Scott Overcash, François Leylavergne, Guennaëlle Dieppois
  • Synergistic Activity of Exebacase (CF-301) in Addition to Daptomycin against <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> in a Neutropenic Murine Thigh Infection Model
    Experimental Therapeutics
    Synergistic Activity of Exebacase (CF-301) in Addition to Daptomycin against Staphylococcus aureus in a Neutropenic Murine Thigh Infection Model

    We evaluated the efficacy of escalating doses of exebacase administered with subtherapeutic daptomycin exposures against 8 Staphylococcus aureus isolates in a neutropenic murine thigh infection model. Daptomycin alone resulted in mean growth of 0.39 ± 1.19 log10 CFU/thigh.

    Tomefa E. Asempa, Kamilia Abdelraouf, Teresa Carabeo, Raymond Schuch, David P. Nicolau
  • Antimicrobial Activity of Exebacase (Lysin CF-301) against the Most Common Causes of Infective Endocarditis
    Experimental Therapeutics
    Antimicrobial Activity of Exebacase (Lysin CF-301) against the Most Common Causes of Infective Endocarditis

    Exebacase, a recombinantly produced lysin (cell wall hydrolase), and comparator antibiotics were tested by the broth microdilution method against strain sets of Staphylococcus and Streptococcus spp., which are the most common causes of infective endocarditis in humans. Exebacase was active against all Staphylococcus spp. tested, including S. aureus...

    Aubrey Watson, Jun Taek Oh, Karen Sauve, Patricia A. Bradford, Cara Cassino, Raymond Schuch
  • A Novel, Widespread <em>qacA</em> Allele Results in Reduced Chlorhexidine Susceptibility in <em>Staphylococcus epidermidis</em>
    Editor's Pick Mechanisms of Resistance
    A Novel, Widespread qacA Allele Results in Reduced Chlorhexidine Susceptibility in Staphylococcus epidermidis

    Chlorhexidine gluconate (CHG) is a topical antiseptic widely used in health care settings. In Staphylococcus spp., the pump QacA effluxes CHG, while the closely related QacB cannot due to a single amino acid substitution.

    Amin Addetia, Alexander L. Greninger, Amanda Adler, Shuhua Yuan, Negar Makhsous, Xuan Qin, Danielle M. Zerr
  • Role of Rifampin against Staphylococcal Biofilm Infections <em>In Vitro</em>, in Animal Models, and in Orthopedic-Device-Related Infections
    Minireview
    Role of Rifampin against Staphylococcal Biofilm Infections In Vitro, in Animal Models, and in Orthopedic-Device-Related Infections

    Rifampin has been used as an agent in combination therapy in orthopedic device-related infections (ODRI) for almost three decades. The aim of this review is to provide data regarding the role of rifampin against biofilm infection in vitro, in animal models, and in clinical ODRI.

    Werner Zimmerli, Parham Sendi
  • Rifampin Resistance in Staphylococci after Rifaximin Intake for Surgical Prophylaxis in Elective Colorectal Surgery
    Susceptibility
    Rifampin Resistance in Staphylococci after Rifaximin Intake for Surgical Prophylaxis in Elective Colorectal Surgery

    The aim of our study was to determine whether rifampin resistance emerges in human skin staphylococci after oral intake of rifaximin for surgical prophylaxis. Rifampin-resistant staphylococci appeared on the skin of 32 out of 74 patients (43.2%) two weeks after prophylactic treatment with rifaximin.

    Emma Padilla, Lluis Oms, Elena Espejo, Laura Gómez, Lurdes Pagespetit, Núria Boada, Feliu Bella, Josefa Pérez
  • Mechanisms of Resistance
    Colocation of the Multiresistance Gene cfr and the Fosfomycin Resistance Gene fosD on a Novel Plasmid in Staphylococcus arlettae from a Chicken Farm
    Bi-Hui Liu, Chang-Wei Lei, An-Yun Zhang, Yun Pan, Ling-Han Kong, Rong Xiang, Yong-Xiang Wang, Yan-Xian Yang, Hong-Ning Wang
  • Clinical Therapeutics
    Intracavitary and Systemic Daptomycin for Successful Treatment of a Postpneumonectomy Intrathoracic Infection
    Paloma Sangro, Francisco Carmona-Torre, Miguel Mesa, Jose L. Del Pozo, Jose R. Yuste

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