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Staphylococcus aureus

  • Concurrent Local Delivery of Diflunisal Limits Bone Destruction but Fails To Improve Systemic Vancomycin Efficacy during <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Osteomyelitis
    Clinical Therapeutics
    Concurrent Local Delivery of Diflunisal Limits Bone Destruction but Fails To Improve Systemic Vancomycin Efficacy during Staphylococcus aureus Osteomyelitis

    Staphylococcus aureus osteomyelitis is a debilitating infection of bone. Treatment of osteomyelitis is impaired by the propensity of invading bacteria to induce pathological bone remodeling that may limit antibiotic penetration to the infectious focus. The nonsteroidal anti-inflammatory drug diflunisal was previously identified as an osteoprotective adjunctive therapy...

    Thomas J. Spoonmore, Caleb A. Ford, Jacob M. Curry, Scott A. Guelcher, James E. Cassat
  • Stp1 Loss of Function Promotes β-Lactam Resistance in <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> That Is Independent of Classical Genes
    Mechanisms of Resistance
    Stp1 Loss of Function Promotes β-Lactam Resistance in Staphylococcus aureus That Is Independent of Classical Genes

    β-Lactam resistance in Staphylococcus aureus limits treatment options. Stp1 and Stk1, a serine-threonine phosphatase and kinase, respectively, mediate serine-threonine kinase (STK) signaling. Loss-of-function point mutations in stp1 were detected among laboratory-passaged β-lactam-resistant S....

    Aditi Chatterjee, Raymond Poon, Som S. Chatterjee
  • Open Access
    Antimicrobial Activity of the Quinoline Derivative HT61 against <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Biofilms
    Susceptibility
    Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms

    Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing ...

    C. J. Frapwell, P. J. Skipp, R. P. Howlin, E. M. Angus, Y. Hu, A. R. M. Coates, R. N. Allan, J. S. Webb
  • Hydrogen Peroxide-Generating Electrochemical Scaffold Activity against Trispecies Biofilms
    Experimental Therapeutics
    Hydrogen Peroxide-Generating Electrochemical Scaffold Activity against Trispecies Biofilms

    The antibiofilm activity of a hydrogen peroxide-generating electrochemical scaffold (e-scaffold) was determined against mono- and trispecies biofilms of methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aeruginosa, and...

    Yash S. Raval, Abdelrhman Mohamed, James Song, Kerryl E. Greenwood-Quaintance, Haluk Beyenal, Robin Patel
  • Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Necrotizing Pneumonia
    Experimental Therapeutics
    Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia

    Staphylococcus aureus is a major human pathogen that causes a wide range of infections by producing an arsenal of cytotoxins.

    Trang T. T. Vu, Nhu T. Q. Nguyen, Vuvi G. Tran, Emmanuelle Gras, Yanjie Mao, David H. Jung, Christine Tkaczyk, Bret R. Sellman, Binh An Diep
  • Evaluation of the Activity of a Combination of Three Bacteriophages Alone or in Association with Antibiotics on <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Embedded in Biofilm or Internalized in Osteoblasts
    Editor's Pick Experimental Therapeutics
    Evaluation of the Activity of a Combination of Three Bacteriophages Alone or in Association with Antibiotics on Staphylococcus aureus Embedded in Biofilm or Internalized in Osteoblasts

    Staphylococcus aureus is responsible for difficult-to-treat bone and joint infections (BJIs). This is related to its ability to form biofilm and to be internalized and persist inside osteoblasts. Recently, bacteriophage therapy has emerged as a promising option to improve treatment of such infections, but data on its activity against the specific bacterial lifestyles...

    Camille Kolenda, Jérôme Josse, Mathieu Medina, Cindy Fevre, Sébastien Lustig, Tristan Ferry, Frédéric Laurent
  • Subinhibitory Concentrations of Mupirocin Stimulate <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Biofilm Formation by Upregulating <em>cidA</em>
    Mechanisms of Action: Physiological Effects
    Subinhibitory Concentrations of Mupirocin Stimulate Staphylococcus aureus Biofilm Formation by Upregulating cidA

    Previous studies have shown that the administration of antibiotics at subinhibitory concentrations stimulates biofilm formation by the majority of multidrug-resistant Staphylococcus aureus (MRSA) strains. Here, we investigated the effect of subinhibitory concentrations of mupirocin on biofilm formation by the community-associated (CA) mupirocin-sensitive MRSA strain...

    Ye Jin, Yinjuan Guo, Qing Zhan, Yongpeng Shang, Di Qu, Fangyou Yu
  • Clinical Mutations That Partially Activate the Stringent Response Confer Multidrug Tolerance in <em>Staphylococcus aureus</em>
    Mechanisms of Resistance
    Clinical Mutations That Partially Activate the Stringent Response Confer Multidrug Tolerance in Staphylococcus aureus

    Antibiotic tolerance is an underappreciated antibiotic escape strategy that is associated with recurrent and relapsing infections, as well as acting as a precursor to resistance. Tolerance describes the ability of a bacterial population to survive transient exposure to an otherwise lethal concentration of antibiotic without exhibiting an elevated MIC.

    Duncan Bryson, Andrew G. Hettle, Alisdair B. Boraston, Joanne K. Hobbs
  • Ability of Bicarbonate Supplementation To Sensitize Selected Methicillin-Resistant <em>Staphylococcus aureus</em> Strains to β-Lactam Antibiotics in an <em>Ex Vivo</em> Simulated Endocardial Vegetation Model
    Experimental Therapeutics
    Ability of Bicarbonate Supplementation To Sensitize Selected Methicillin-Resistant Staphylococcus aureus Strains to β-Lactam Antibiotics in an Ex Vivo Simulated Endocardial Vegetation Model

    Supplementation of standard growth media (cation-adjusted Mueller-Hinton Broth [CAMHB]) with bicarbonate (NaHCO3) increases β-lactam susceptibility of selected methicillin-resistant Staphylococcus aureus (MRSA) strains (“NaHCO3 responsive”). This “sensitization” phenomenon translated to enhanced β-lactam efficacy in a rabbit model of endocarditis...

    Warren E. Rose, Ana M. Bienvenida, Yan Q. Xiong, Henry F. Chambers, Arnold S. Bayer, Selvi C. Ersoy
  • Relationship between Vancomycin MIC and Virulence Gene Expression in Clonal Complexes of Methicillin-Susceptible <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Strains Isolated from Left-Sided Endocarditis
    Clinical Therapeutics
    Relationship between Vancomycin MIC and Virulence Gene Expression in Clonal Complexes of Methicillin-Susceptible Staphylococcus aureus Strains Isolated from Left-Sided Endocarditis

    Higher vancomycin MICs have been associated with more complicated courses and higher mortality rates in patients with Staphylococcus aureus bacteremia and infective endocarditis (IE).

    Juan M. Pericàs, Carlos Cervera, Cristina Garcia-de-la-Mària, Batu K. Sharma-Kuinkel, Rachelle Gonzales, Asunción Moreno, Manel Almela, Carlos Falces, Eduard Quintana, David Fuster, Francesc Marco, Arnold S. Bayer, Vance G. Fowler, José M. Miró
    and the Hospital Clinic Endocarditis Study Group

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