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Staphylococcus epidermidis

  • Rifampin, Rifapentine, and Rifabutin Are Active against Intracellular Periprosthetic Joint Infection-Associated <span class="named-content genus-species" id="named-content-1">Staphylococcus epidermidis</span>
    Susceptibility
    Rifampin, Rifapentine, and Rifabutin Are Active against Intracellular Periprosthetic Joint Infection-Associated Staphylococcus epidermidis

    Staphylococcus epidermidis is a major cause of periprosthetic joint infection (PJI); its intracellular persistence within osteoblasts may compromise therapy if that therapy is not intracellularly active. The intracellular activity of rifampin, rifapentine, and rifabutin was assessed against five rifampin-susceptible and two rifampin-resistant...

    Cody Fisher, Robin Patel
  • Vancomycin Heteroresistance and Clinical Outcomes in Bloodstream Infections Caused by Coagulase-Negative Staphylococci
    Editor's Pick Mechanisms of Resistance
    Vancomycin Heteroresistance and Clinical Outcomes in Bloodstream Infections Caused by Coagulase-Negative Staphylococci

    Coagulase-negative staphylococci (CoNS) are a common etiology of serious and recurrent infections in immunocompromised patients. Although most isolates appear susceptible to vancomycin, a single strain might have a subpopulation of resistant bacteria. This phenomenon is termed heteroresistance and may adversely affect the response to treatment. A retrospective cohort study was performed of pediatric patients with leukemia treated at St...

    Tina H. Dao, Ramzi Alsallaq, Joshua B. Parsons, Jose Ferrolino, Randall T. Hayden, Jeffrey E. Rubnitz, Iftekhar M. Rafiqullah, D. Ashley Robinson, Elisa B. Margolis, Jason W. Rosch, Joshua Wolf
  • Vancomycin Is Protective in a Neonatal Mouse Model of <em>Staphylococcus epidermidis</em>-Potentiated Hypoxic-Ischemic Brain Injury
    Editor's Pick Experimental Therapeutics
    Vancomycin Is Protective in a Neonatal Mouse Model of Staphylococcus epidermidis-Potentiated Hypoxic-Ischemic Brain Injury

    Infection is correlated with increased risk of neurodevelopmental sequelae in preterm infants. In modeling neonatal brain injury, Toll-like receptor agonists have often been used to mimic infections and induce inflammation. Using the most common cause of bacteremia in preterm infants, Staphylococcus epidermidis, we present a more clinically relevant neonatal mouse...

    Jacqueline C. Y. Lai, Pernilla Svedin, C. Joakim Ek, Amin Mottahedin, Xiaoyang Wang, Ofer Levy, Andrew Currie, Tobias Strunk, Carina Mallard
  • <em>In Vitro</em> Activity of Rifampin, Rifabutin, Rifapentine, and Rifaximin against Planktonic and Biofilm States of Staphylococci Isolated from Periprosthetic Joint Infection
    Susceptibility
    In Vitro Activity of Rifampin, Rifabutin, Rifapentine, and Rifaximin against Planktonic and Biofilm States of Staphylococci Isolated from Periprosthetic Joint Infection

    The in vitro activities of rifampin, rifabutin, rifapentine, and rifaximin were tested against 200 periprosthetic joint infection (PJI)-associated staphylococci. Seven rifampin-resistant isolates had MICs of ≥4 μg/ml. Three isolates had rifampin MICs of 0.25 to 1 μg/ml and harbored an Asp471Gly RpoB variant, suggesting that the CLSI rifampin-susceptible staphylococcal breakpoint of ≤1 μg/ml may be too high.

    Mariana Albano, Melissa J. Karau, Kerryl E. Greenwood-Quaintance, Douglas R. Osmon, Caitlin P. Oravec, Daniel J. Berry, Matthew P. Abdel, Robin Patel
  • A Novel, Widespread <em>qacA</em> Allele Results in Reduced Chlorhexidine Susceptibility in <em>Staphylococcus epidermidis</em>
    Editor's Pick Mechanisms of Resistance
    A Novel, Widespread qacA Allele Results in Reduced Chlorhexidine Susceptibility in Staphylococcus epidermidis

    Chlorhexidine gluconate (CHG) is a topical antiseptic widely used in health care settings. In Staphylococcus spp., the pump QacA effluxes CHG, while the closely related QacB cannot due to a single amino acid substitution.

    Amin Addetia, Alexander L. Greninger, Amanda Adler, Shuhua Yuan, Negar Makhsous, Xuan Qin, Danielle M. Zerr
  • Pharmacology
    Activities of Combinations of Antistaphylococcal Antibiotics with Fusidic Acid against Staphylococcal Biofilms in In Vitro Static and Dynamic Models
    Wafi Siala, Hector Rodriguez-Villalobos, Prabhavathi Fernandes, Paul M. Tulkens, Françoise Van Bambeke
  • Open Access
    Epidemiology and Surveillance
    First Detailed Genetic Characterization of the Structural Organization of Type III Arginine Catabolic Mobile Elements Harbored by Staphylococcus epidermidis by Using Whole-Genome Sequencing
    Brenda A. McManus, Aoife M. O'Connor, Peter M. Kinnevey, Michael O'Sullivan, Ioannis Polyzois, David C. Coleman
  • Susceptibility
    Pharmacokinetics of Cefuroxime in Synovial Fluid
    R. Schwameis, S. Syré, D. Marhofer, A. Appelt, D. Burau, K. Sarahrudi, C. Kloft, M. Zeitlinger
  • Experimental Therapeutics
    Efficient Killing of Planktonic and Biofilm-Embedded Coagulase-Negative Staphylococci by Bactericidal Protein P128
    Nethravathi Poonacha, Sandhya Nair, Srividya Desai, Darshan Tuppad, Deepika Hiremath, Thulasi Mohan, Aradhana Vipra, Umender Sharma
  • Clinical Therapeutics
    Activity of Tedizolid in Methicillin-Resistant Staphylococcus epidermidis Experimental Foreign Body-Associated Osteomyelitis
    Kyung-Hwa Park, Kerryl E. Greenwood-Quaintance, Audrey N. Schuetz, Jayawant N. Mandrekar, Robin Patel

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