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stewardship

  • Decreased Overall and Inappropriate Antibiotic Prescribing in a Veterans Affairs Hospital Emergency Department following a Peer Comparison-Based Stewardship Intervention
    Clinical Therapeutics
    Decreased Overall and Inappropriate Antibiotic Prescribing in a Veterans Affairs Hospital Emergency Department following a Peer Comparison-Based Stewardship Intervention

    Antibiotic prescribing is very common in emergency departments (EDs). Optimal stewardship intervention strategies in EDs are not well defined. We conducted a prospective, observational cohort study in a Veterans Affairs ED in which clinician education and monthly e-mail-based peer comparisons were directed against all oral antibiotic prescribing for discharged patients. Oral antibiotic prescriptions were compared in baseline (June 2016...

    Deanna J. Buehrle, Rameez H. Phulputo, Marilyn M. Wagener, Cornelius J. Clancy, Brooke K. Decker
  • Utility of Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Nares Screening for Patients with a Diabetic Foot Infection
    Clinical Therapeutics
    Utility of Methicillin-Resistant Staphylococcus aureus Nares Screening for Patients with a Diabetic Foot Infection

    Treatment of suspected methicillin-resistant Staphylococcus aureus (MRSA) is a cornerstone of severe diabetic foot infections; however, antibiotics can be associated with toxicity. The objective of this study was to determine the negative predictive value (NPV) of MRSA nares screening in the determination of subsequent MRSA in patients with a diabetic foot infection....

    Kari A. Mergenhagen, Michael Croix, Kaitlyn E. Starr, John A. Sellick, Alan J. Lesse
  • Comparison of Pharmacist-Directed Management of Multiplex PCR Blood Culture Results with Conventional Microbiology Methods on Effective and Optimal Therapy within a Community Hospital
    Editor's Pick Clinical Therapeutics
    Comparison of Pharmacist-Directed Management of Multiplex PCR Blood Culture Results with Conventional Microbiology Methods on Effective and Optimal Therapy within a Community Hospital

    Multiplex PCR combined with a pharmacist-driven reporting protocol was compared to the standard of care within a community hospital to evaluate initial changes after notification of a positive blood culture. The intervention group demonstrated decreased times to changes in antimicrobial therapy (P = 0.0081), increased changes to optimal antimicrobial therapy (P = 0.013), and decreased vancomycin use for coagulase-...

    Allison M. Porter, Christopher M. Bland, Henry N. Young, David R. Allen, Sabrina R. Croft, R. Ellen Gayheart, Parks W. Miller, Rachel J. Musgrove, Emilee M. Robertson, Geneen M. Gibson
  • Clinical Therapeutics
    An Antibiotic Stewardship Program Blueprint for Optimizing Verigene BC-GN within an Institution: a Tale of Two Cities
    Jason M. Pogue, Emily L. Heil, Paul Lephart, J. Kristie Johnson, Ryan P. Mynatt, Hossein Salimnia, Kimberly C. Claeys
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