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therapy

  • Open Access
    Inhibition of Fatty Acid Oxidation as a New Target To Treat Primary Amoebic Meningoencephalitis
    Experimental Therapeutics
    Inhibition of Fatty Acid Oxidation as a New Target To Treat Primary Amoebic Meningoencephalitis

    Primary amoebic meningoencephalitis (PAM) is a rapidly fatal infection caused by the free-living amoeba Naegleria fowleri. The amoeba migrates along the olfactory nerve to the brain, resulting in seizures, coma, and, eventually, death. Previous research has shown that Naegleria gruberi, a close...

    Maarten J. Sarink, Aloysius G. M. Tielens, Annelies Verbon, Robert Sutak, Jaap J. van Hellemond
  • Combination Therapy Using Benznidazole and Aspirin during the Acute Phase of Experimental Chagas Disease Prevents Cardiovascular Dysfunction and Decreases Typical Cardiac Lesions in the Chronic Phase
    Clinical Therapeutics
    Combination Therapy Using Benznidazole and Aspirin during the Acute Phase of Experimental Chagas Disease Prevents Cardiovascular Dysfunction and Decreases Typical Cardiac Lesions in the Chronic Phase

    Chagas disease, caused by the protozoan Trypanosoma cruzi, is one of the main causes of death due to cardiomyopathy and heart failure in Latin American countries. The treatment of Chagas disease is directed at eliminating the parasite, decreasing the probability of cardiomyopathy and disrupting the disease transmission cycle. Benznidazole (BZ) and nifurtimox (Nfx) are...

    Rito Santo Pereira, Aparecida Donizette Malvezi, Maria Isabel Lovo-Martins, Bruno Fernando Cruz Lucchetti, Jussevania Pereira Santos, Eliandro Reis Tavares, Waldiceu Aparecido Verri, Eduardo José de Almeida Araújo, Lucy Megumi Yamauchi, Sueli Fumie Yamada-Ogatta, Marli Cardoso Martins-Pinge, Phileno Pinge-Filho
  • Antiviral Agents
    High Dose and Delayed Treatment with Bile Acids Ineffective in RML Prion-Infected Mice
    Grant Norman, Jody Campeau, Valerie L. Sim
  • Experimental Therapeutics
    A Novel Rabbit Spirometry Model of Type E Botulism and Its Use for the Evaluation of Postsymptom Antitoxin Efficacy
    Eran Diamant, Avi Pass, Osnat Rosen, Alon Ben David, Amram Torgeman, Ada Barnea, Arnon Tal, Amir Rosner, Ran Zichel
  • Antiviral Agents
    A Promising Antiprion Trimethoxychalcone Binds to the Globular Domain of the Cellular Prion Protein and Changes Its Cellular Location
    N. C. Ferreira, L. M. Ascari, A. G. Hughson, G. R. Cavalheiro, C. F. Góes, P. N. Fernandes, J. R. Hollister, R. A. da Conceição, D. S. Silva, A. M. T. Souza, M. L. C. Barbosa, F. A. Lara, R. A. P. Martins, B. Caughey, Y. Cordeiro
  • Experimental Therapeutics
    Efficacy of Telavancin Alone and in Combination with Ampicillin in a Rat Model of Enterococcus faecalis Endocarditis
    Truc T. Tran, Vincent H. Tam, Barbara E. Murray, Cesar A. Arias, Kavindra V. Singh
  • Pharmacology
    Nanoliposomal Buparvaquone Immunomodulates Leishmania infantum-Infected Macrophages and Is Highly Effective in a Murine Model
    Thais Alves da Costa-Silva, Andrés Jimenez Galisteo, José Angelo Lauletta Lindoso, Leandro R. S. Barbosa, Andre Gustavo Tempone
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