Thienamycins

Open Access

Mechanisms of Resistance
Meropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae
Dongxu Sun, Debora Rubio-Aparicio, Kirk Nelson, Michael N. Dudley, Olga Lomovskaya
Experimental Therapeutics
Pharmacokinetics-Pharmacodynamics of CB-618 in Combination with Cefepime, Ceftazidime, Ceftolozane, or Meropenem: the Pharmacological Basis for a Stand-Alone β-Lactamase Inhibitor
Paul G. Ambrose, Brian D. VanScoy, Michael Trang, Jennifer McCauley-Miller, Haley Conde, Sujata M. Bhavnani, Dylan C. Alexander, Lawrence V. Friedrich
Clinical Therapeutics
Influence of β-Lactam Infusion Strategy on Acute Kidney Injury
Sarah E. Cotner, W. Cliff Rutter, Donna R. Burgess, Katie L. Wallace, Craig A. Martin, David S. Burgess
Susceptibility
Multicenter Evaluation of Ceftazidime-Avibactam and Ceftolozane-Tazobactam Inhibitory Activity against Meropenem-Nonsusceptible Pseudomonas aeruginosa from Blood, Respiratory Tract, and Wounds
Mordechai Grupper, Christina Sutherland, David P. Nicolau
Clinical Therapeutics
Population Pharmacokinetics of High-Dose Continuous-Infusion Meropenem and Considerations for Use in the Treatment of Infections Due to KPC-Producing Klebsiella pneumoniae
Piergiorgio Cojutti, Assunta Sartor, Elda Righi, Claudio Scarparo, Matteo Bassetti, Federico Pea
Epidemiology and Surveillance
Meropenem-Vaborbactam Tested against Contemporary Gram-Negative Isolates Collected Worldwide during 2014, Including Carbapenem-Resistant, KPC-Producing, Multidrug-Resistant, and Extensively Drug-Resistant Enterobacteriaceae
Mariana Castanheira, Michael D. Huband, Rodrigo E. Mendes, Robert K. Flamm
Clinical Therapeutics
Mortality Associated with Bacteremia Due to Colistin-Resistant Klebsiella pneumoniae with High-Level Meropenem Resistance: Importance of Combination Therapy without Colistin and Carbapenems
Isabel Machuca, Belén Gutiérrez-Gutiérrez, Irene Gracia-Ahufinger, Francisco Rivera Espinar, Ángela Cano, Julia Guzmán-Puche, Elena Pérez-Nadales, Clara Natera, Marina Rodríguez, Rafael León, Juan J. Castón, Fernando Rodríguez-López, Jesús Rodríguez-Baño, Julián Torre-Cisneros
Pharmacology
Substantial Impact of Altered Pharmacokinetics in Critically Ill Patients on the Antibacterial Effects of Meropenem Evaluated via the Dynamic Hollow-Fiber Infection Model
Phillip J. Bergen, Jürgen B. Bulitta, Carl M. J. Kirkpatrick, Kate E. Rogers, Megan J. McGregor, Steven C. Wallis, David L. Paterson, Roger L. Nation, Jeffrey Lipman, Jason A. Roberts, Cornelia B. Landersdorfer
Mechanisms of Resistance
In Vitro Selection of Meropenem Resistance among Ceftazidime-Avibactam-Resistant, Meropenem-Susceptible Klebsiella pneumoniae Isolates with Variant KPC-3 Carbapenemases
Ryan K. Shields, M. Hong Nguyen, Ellen G. Press, Liang Chen, Barry N. Kreiswirth, Cornelius J. Clancy
Pharmacology
New Polymyxin B Dosing Strategies To Fortify Old Allies in the War against KPC-2-Producing Klebsiella pneumoniae
Zackery P. Bulman, Michael J. Satlin, Liang Chen, Barry N. Kreiswirth, Beom Soo Shin, Thomas J. Walsh, Patricia N. Holden, Alan Forrest, Roger L. Nation, Jian Li, Brian T. Tsuji

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