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Thienamycins

  • Open Access
    Mechanisms of Resistance
    Meropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae
    Dongxu Sun, Debora Rubio-Aparicio, Kirk Nelson, Michael N. Dudley, Olga Lomovskaya
  • Experimental Therapeutics
    Pharmacokinetics-Pharmacodynamics of CB-618 in Combination with Cefepime, Ceftazidime, Ceftolozane, or Meropenem: the Pharmacological Basis for a Stand-Alone β-Lactamase Inhibitor
    Paul G. Ambrose, Brian D. VanScoy, Michael Trang, Jennifer McCauley-Miller, Haley Conde, Sujata M. Bhavnani, Dylan C. Alexander, Lawrence V. Friedrich
  • Clinical Therapeutics
    Influence of β-Lactam Infusion Strategy on Acute Kidney Injury
    Sarah E. Cotner, W. Cliff Rutter, Donna R. Burgess, Katie L. Wallace, Craig A. Martin, David S. Burgess
  • Susceptibility
    Multicenter Evaluation of Ceftazidime-Avibactam and Ceftolozane-Tazobactam Inhibitory Activity against Meropenem-Nonsusceptible Pseudomonas aeruginosa from Blood, Respiratory Tract, and Wounds
    Mordechai Grupper, Christina Sutherland, David P. Nicolau
  • Clinical Therapeutics
    Population Pharmacokinetics of High-Dose Continuous-Infusion Meropenem and Considerations for Use in the Treatment of Infections Due to KPC-Producing Klebsiella pneumoniae
    Piergiorgio Cojutti, Assunta Sartor, Elda Righi, Claudio Scarparo, Matteo Bassetti, Federico Pea
  • Epidemiology and Surveillance
    Meropenem-Vaborbactam Tested against Contemporary Gram-Negative Isolates Collected Worldwide during 2014, Including Carbapenem-Resistant, KPC-Producing, Multidrug-Resistant, and Extensively Drug-Resistant Enterobacteriaceae
    Mariana Castanheira, Michael D. Huband, Rodrigo E. Mendes, Robert K. Flamm
  • Clinical Therapeutics
    Mortality Associated with Bacteremia Due to Colistin-Resistant Klebsiella pneumoniae with High-Level Meropenem Resistance: Importance of Combination Therapy without Colistin and Carbapenems
    Isabel Machuca, Belén Gutiérrez-Gutiérrez, Irene Gracia-Ahufinger, Francisco Rivera Espinar, Ángela Cano, Julia Guzmán-Puche, Elena Pérez-Nadales, Clara Natera, Marina Rodríguez, Rafael León, Juan J. Castón, Fernando Rodríguez-López, Jesús Rodríguez-Baño, Julián Torre-Cisneros
  • Pharmacology
    Substantial Impact of Altered Pharmacokinetics in Critically Ill Patients on the Antibacterial Effects of Meropenem Evaluated via the Dynamic Hollow-Fiber Infection Model
    Phillip J. Bergen, Jürgen B. Bulitta, Carl M. J. Kirkpatrick, Kate E. Rogers, Megan J. McGregor, Steven C. Wallis, David L. Paterson, Roger L. Nation, Jeffrey Lipman, Jason A. Roberts, Cornelia B. Landersdorfer
  • Mechanisms of Resistance
    In Vitro Selection of Meropenem Resistance among Ceftazidime-Avibactam-Resistant, Meropenem-Susceptible Klebsiella pneumoniae Isolates with Variant KPC-3 Carbapenemases
    Ryan K. Shields, M. Hong Nguyen, Ellen G. Press, Liang Chen, Barry N. Kreiswirth, Cornelius J. Clancy
  • Pharmacology
    New Polymyxin B Dosing Strategies To Fortify Old Allies in the War against KPC-2-Producing Klebsiella pneumoniae
    Zackery P. Bulman, Michael J. Satlin, Liang Chen, Barry N. Kreiswirth, Beom Soo Shin, Thomas J. Walsh, Patricia N. Holden, Alan Forrest, Roger L. Nation, Jian Li, Brian T. Tsuji

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