thiols
Chemistry; BiosynthesisNew Amides Containing Selenium as Potent Leishmanicidal Agents Targeting Trypanothione ReductaseTwo new series of 28 selenocyanate and diselenide derivatives containing amide moieties were designed, synthesized, and evaluated for their leishmanicidal activity against Leishmania infantum axenic amastigotes, and selectivity was assessed in human THP-1 cells. Eleven compounds exhibited excellent leishmanicidal activity with EC50 values lower than the...