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Topoisomerase II Inhibitors

  • Susceptibility
    In Vitro Activities of Gepotidacin (GSK2140944) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas
    Ken B. Waites, Donna M. Crabb, Li Xiao, Lynn B. Duffy
  • Experimental Therapeutics
    Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria
    Cédric Charrier, Anne-Marie Salisbury, Victoria J. Savage, Thomas Duffy, Emmanuel Moyo, Nathan Chaffer-Malam, Nicola Ooi, Rebecca Newman, Jonathan Cheung, Richard Metzger, David McGarry, Mark Pichowicz, Ralph Sigerson, Ian R. Cooper, Gary Nelson, Hayley S. Butler, Mark Craighead, Andrew J. Ratcliffe, Stuart A. Best, Neil R. Stokes
  • Mechanisms of Action: Physiological Effects
    Newly Identified Antibacterial Compounds Are Topoisomerase Poisons in African Trypanosomes
    Sonya C. Tang, Theresa A. Shapiro
  • Mechanisms of Action: Physiological Effects
    Probing the Differential Interactions of Quinazolinedione PD 0305970 and Quinolones with Gyrase and Topoisomerase IV
    Xiao-Su Pan, Katherine A. Gould, L. Mark Fisher
  • Mechanisms of Action: Physiological Effects
    Mechanism of Action of the Antibiotic NXL101, a Novel Nonfluoroquinolone Inhibitor of Bacterial Type II Topoisomerases
    Michael T. Black, Thérèse Stachyra, Denis Platel, Anne-Marie Girard, Monique Claudon, Jean-Michel Bruneau, Christine Miossec
  • Mechanisms of Action: Physiological Effects
    Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors
    Alita A. Miller, Gordon L. Bundy, John E. Mott, Jill E. Skepner, Timothy P. Boyle, Douglas W. Harris, Alexander E. Hromockyj, Keith R. Marotti, Gary E. Zurenko, Jennifer B. Munzner, Michael T. Sweeney, Gary F. Bammert, Judith C. Hamel, Charles W. Ford, Wei-Zhu Zhong, David R. Graber, Gary E. Martin, Fusen Han, Lester A. Dolak, Eric P. Seest, J. Craig Ruble, Gregg M. Kamilar, John R. Palmer, Lee S. Banitt, Alexander R. Hurd, Michael R. Barbachyn
  • Chemistry; Biosynthesis
    Biological Activities of Novel Gyrase Inhibitors of the Aminocoumarin Class
    Christine Anderle, Martin Stieger, Matthew Burrell, Stefan Reinelt, Anthony Maxwell, Malcolm Page, Lutz Heide
  • Chemistry; Biosynthesis
    Discovery of Novel DNA Gyrase Inhibitors by High-Throughput Virtual Screening
    David A. Ostrov, José A. Hernández Prada, Patrick E. Corsino, Kathryn A. Finton, Nhan Le, Thomas C. Rowe
  • Mechanisms of Action: Physiological Effects
    Dual Targeting of DNA Gyrase and Topoisomerase IV: Target Interactions of Heteroaryl Isothiazolones in Staphylococcus aureus
    Jijun Cheng, Jane A. Thanassi, Christy L. Thoma, Barton J. Bradbury, Milind Deshpande, Michael J. Pucci
  • Susceptibility
    Expression and Purification of an Active Form of the Mycobacterium leprae DNA Gyrase and Its Inhibition by Quinolones
    Stéphanie Matrat, Stéphanie Petrella, Emmanuelle Cambau, Wladimir Sougakoff, Vincent Jarlier, Alexandra Aubry

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