Triazines
Chemistry; BiosynthesisRegioisomerization of Antimalarial Drug WR99210 Explains the Inactivity of a Commercial StockWR99210, a former antimalarial drug candidate now widely used for the selection of Plasmodium transfectants, selectively targets the parasite’s dihydrofolate reductase thymidine synthase bifunctional enzyme (DHFR-TS) but not human DHFR, which is not fused with TS. Accordingly, WR99210 and plasmids expressing the human dhfr gene have become valued tools for the genetic modification of parasites in the laboratory....
- Experimental TherapeuticsTriazine Inhibits Toxoplasma gondii Tachyzoites In Vitro and In Vivo
- Experimental TherapeuticsTrypanocidal Activity of Melamine-Based Nitroheterocycles
- Mechanisms of Action: Physiological EffectsNovel Saccharomyces cerevisiae Screen Identifies WR99210 Analogues That Inhibit Mycobacterium tuberculosis Dihydrofolate Reductase
- Antiviral AgentsRFI-641, a Potent Respiratory Syncytial Virus Inhibitor