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tribendimidine

  • Pharmacometric Analysis of Tribendimidine Monotherapy and Combination Therapies To Achieve High Cure Rates in Patients with Hookworm Infections
    Clinical Therapeutics
    Pharmacometric Analysis of Tribendimidine Monotherapy and Combination Therapies To Achieve High Cure Rates in Patients with Hookworm Infections

    In the treatment of hookworm infections, pharmacotherapy has been only moderately successful and drug resistance is a threat. Therefore, novel treatment options including combination therapies should be considered, in which tribendimidine could play a role. Our aims were to (i) characterize the pharmacokinetics of tribendimidine’s metabolites in adolescents receiving tribendimidine monotherapy or in combination with ivermectin or...

    Janneke M. Brussee, Anna Neodo, Jessica D. Schulz, Jean T. Coulibaly, Marc Pfister, Jennifer Keiser
  • Population Pharmacokinetics and Exposure-Response Analysis of Tribendimidine To Improve Treatment for Children with Hookworm Infection
    Clinical Therapeutics
    Population Pharmacokinetics and Exposure-Response Analysis of Tribendimidine To Improve Treatment for Children with Hookworm Infection

    Tribendimidine has been successful in treating hookworm infections and may serve as an alternative to albendazole should resistance arise. Our aims were to (i) characterize the pharmacokinetics (PK) of tribendimidine’s primary metabolite, deacetylated amidantel (dADT), and secondary metabolite, acetylated derivative of amidantel (adADT), in school-aged children and adolescents, (ii) link exposure to efficacy against hookworm, and (iii)...

    Janneke M. Brussee, Noemi Hiroshige, Anna Neodo, Jean T. Coulibaly, Marc Pfister, Jennifer Keiser
  • Open Access
    Pooled Population Pharmacokinetic Analysis of Tribendimidine for the Treatment of <em>Opisthorchis viverrini</em> Infections
    Clinical Therapeutics
    Pooled Population Pharmacokinetic Analysis of Tribendimidine for the Treatment of Opisthorchis viverrini Infections

    Opisthorchiasis, caused by the foodborne trematode Opisthorchis viverrini, affects more than 8 million people in Southeast Asia. In the framework of a phase 2b clinical trial conducted in Lao People’s Democratic Republic, pharmacokinetic samples were obtained from 125 adult and adolescent O. viverrini...

    Isabel Meister, Piyanan Assawasuwannakit, Fiona Vanobberghen, Melissa A. Penny, Peter Odermatt, Somphou Sayasone, Jörg Huwyler, Joel Tarning, Jennifer Keiser
  • <em>In Vitro</em> and <em>In Vivo</em> Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine
    Experimental Therapeutics
    In Vitro and In Vivo Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine

    Soil-transmitted helminth (STH) infections still remain a major health problem in poor rural settings. The lack of efficacious drugs against all STH species raises interest in drug combinations.

    Anna Neodo, Jessica D. Schulz, Jörg Huwyler, Jennifer Keiser
  • Clinical Therapeutics
    Pharmacokinetics of a Pediatric Tribendimidine Dose-Finding Study To Treat Hookworm Infection in African Children

    Tribendimidine is a broad-spectrum anthelminthic available in China, which is currently being pursued for U.S. Food and Drug Administration approval for soil-transmitted helminth infections.

    Noemi Hiroshige, Jean Coulibaly, Jörg Huwyler, Peter L. Bonate, Jennifer Keiser
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