Trichomonas vaginalis
Experimental Therapeutics20S Proteasome as a Drug Target in Trichomonas vaginalisTrichomoniasis is a sexually transmitted disease with hundreds of millions of annual cases worldwide. Approved treatment options are limited to two related nitro-heterocyclic compounds, yet resistance to these drugs is an increasing concern. New antimicrobials against the causative agent, Trichomonas vaginalis, are urgently needed.
- Mechanisms of Action: Physiological EffectsAlternative Pathway of Metronidazole Activation in Trichomonas vaginalis Hydrogenosomes
- Chemistry; BiosynthesisActivities of Dicationic Compounds against Trichomonas vaginalis
- Mechanisms of Action: Physiological EffectsReactivity of Reduced [2Fe-2S] Ferredoxins Parallels Host Susceptibility to Nitroimidazoles