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Trichomonas vaginalis

  • 20S Proteasome as a Drug Target in <span class="named-content genus-species" id="named-content-1">Trichomonas vaginalis</span>
    Experimental Therapeutics
    20S Proteasome as a Drug Target in Trichomonas vaginalis

    Trichomoniasis is a sexually transmitted disease with hundreds of millions of annual cases worldwide. Approved treatment options are limited to two related nitro-heterocyclic compounds, yet resistance to these drugs is an increasing concern. New antimicrobials against the causative agent, Trichomonas vaginalis, are urgently needed.

    Anthony J. O’Donoghue, Betsaida Bibo-Verdugo, Yukiko Miyamoto, Steven C Wang, Justin Z. Yang, Douglas E. Zuill, Shoun Matsuka, Zhenze Jiang, Jehad Almaliti, Conor R. Caffrey, William H. Gerwick, Lars Eckmann
  • Susceptibility
    In Vitro Study of the Susceptibility of Clinical Isolates of Trichomonas vaginalis to Metronidazole and Secnidazole
    Arindam P. Ghosh, Cheri Aycock, Jane R. Schwebke
  • Clinical Therapeutics
    Prevalence of Trichomonas vaginalis Isolates with Resistance to Metronidazole and Tinidazole
    Jane R. Schwebke, Frank J. Barrientes
  • Susceptibility
    5-Nitroimidazole Drugs Effective against Metronidazole-Resistant Trichomonas vaginalis and Giardia duodenalis
    Jacqueline A. Upcroft, Linda A. Dunn, Janelle M. Wright, Kamel Benakli, Peter Upcroft, Patrice Vanelle
  • Mechanisms of Action: Physiological Effects
    Alternative Pathway of Metronidazole Activation in Trichomonas vaginalis Hydrogenosomes
    Ivan Hrdý, Richard Cammack, Pavel Stopka, Jaroslav Kulda, Jan Tachezy
  • Chemistry; Biosynthesis
    Activities of Dicationic Compounds against Trichomonas vaginalis
    Andrea L. Crowell, Chad E. Stephens, Arvind Kumar, David W. Boykin, W. Evan Secor
  • Susceptibility
    In Vitro Metronidazole and Tinidazole Activities against Metronidazole- Resistant Strains of Trichomonas vaginalis
    Andrea L. Crowell, Kolby A. Sanders-Lewis, W. Evan Secor
  • Mechanisms of Action: Physiological Effects
    Reactivity of Reduced [2Fe-2S] Ferredoxins Parallels Host Susceptibility to Nitroimidazoles
    Momcilo Vidakovic, Chetlen R. Crossnoe, Christopher Neidre, Kyonghee Kim, Kurt L. Krause, Juris P. Germanas
  • Susceptibility
    In Vitro Activities of Position 2 Substitution-Bearing 6-Nitro- and 6-Amino-Benzothiazoles and Their Corresponding Anthranilic Acid Derivatives against Leishmania infantum and Trichomonas vaginalis
    Florence Delmas, Carole Di Giorgio, Maxime Robin, Nadine Azas, Monique Gasquet, Claire Detang, Muriel Costa, Pierre Timon-David, Jean-Pierre Galy
  • Experimental Therapeutics
    Trifluoromethionine, a Prodrug Designed against Methionine γ-Lyase-Containing Pathogens, Has Efficacy In Vitro and In Vivo against Trichomonas vaginalis
    Graham H. Coombs, Jeremy C. Mottram

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