trypanothione reductase
Chemistry; BiosynthesisNew Amides Containing Selenium as Potent Leishmanicidal Agents Targeting Trypanothione ReductaseTwo new series of 28 selenocyanate and diselenide derivatives containing amide moieties were designed, synthesized, and evaluated for their leishmanicidal activity against Leishmania infantum axenic amastigotes, and selectivity was assessed in human THP-1 cells. Eleven compounds exhibited excellent leishmanicidal activity with EC50 values lower than the...
Editor's Pick Chemistry; BiosynthesisSynthesis and Leishmanicidal Activity of Novel Urea, Thiourea, and Selenourea Derivatives of DiselenidesA novel series of thirty-one N-substituted urea, thiourea, and selenourea derivatives containing diphenyldiselenide entities were synthesized, fully characterized by spectroscopic and analytical methods, and screened for their in vitro leishmanicidal activities. The cytotoxic activity of these derivatives was tested against Leishmania infantum axenic...