urinary

  • Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury
    Pharmacology
    Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury

    Urinary biomarkers are superior to serum creatinine for defining onset and extent of kidney injury. This study classifies the temporal predictive ability of biomarkers for vancomycin-induced kidney injury (VIKI) as defined by histopathologic damage.

    Gwendolyn M. Pais, Sean N. Avedissian, J. Nicholas O’Donnell, Nathaniel J. Rhodes, Thomas P. Lodise, Walter C. Prozialeck, Peter C. Lamar, Cameron Cluff, Anil Gulati, Julie C. Fitzgerald, Kevin J. Downes, Athena F. Zuppa, Marc H. Scheetz
  • <em>In Vitro</em> Activity of Sulopenem, an Oral Penem, against Urinary Isolates of <em>Escherichia coli</em>
    Susceptibility
    In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli

    The in vitro activity of sulopenem was assessed against a collection from 2014 to 2016 of 539 urinary isolates of Escherichia coli from Canadian patients by using CLSI-defined broth microdilution methodology. A concentration of sulopenem 0.03 µg/ml inhibited both 50% (MIC50) and 90% (MIC90) of isolates tested; sulopenem MICs ranged from...

    James A. Karlowsky, Heather J. Adam, Melanie R. Baxter, Andrew J. Denisuik, Philippe R. S. Lagacé-Wiens, Andrew J. Walkty, Sailaja Puttagunta, Michael W. Dunne, George G. Zhanel
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