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urine

  • <em>Ex Vivo</em> Urinary Bactericidal Activity and Urinary Pharmacodynamics of Fosfomycin after Two Repeated Dosing Regimens of Oral Fosfomycin Tromethamine in Healthy Adult Subjects
    Pharmacology
    Ex Vivo Urinary Bactericidal Activity and Urinary Pharmacodynamics of Fosfomycin after Two Repeated Dosing Regimens of Oral Fosfomycin Tromethamine in Healthy Adult Subjects

    The ex vivo bactericidal activity and pharmacodynamics of fosfomycin in urine were evaluated in 18 healthy subjects. Subjects received 3 g every other day (QOD) for 3 doses and then every day (QD) for 7 doses or vice versa. Serial urine samples were collected before and up to 24 h after dosing on days 1 and 5. Eight bacterial strains with various genotypic and phenotypic susceptibilities to fosfomycin were used for all...

    E. Wenzler, K. M. Meyer, S. C. Bleasdale, M. Sikka, R. E. Mendes, K. L. Bunnell, M. Finnemeyer, S. L. Rosenkranz, L. H. Danziger, K. A. Rodvold
    and for the Antibacterial Resistance Leadership Group
  • Open Access
    Experimental Therapeutics
    Pharmacodynamics of Finafloxacin, Ciprofloxacin, and Levofloxacin in Serum and Urine against TEM- and SHV-Type Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae Isolates from Patients with Urinary Tract Infections
    A. Dalhoff, S. Schubert, A. Vente
  • Pharmacology
    Urine Bactericidal Activity against Escherichia coli Isolates Exhibiting Different Resistance Phenotypes/Genotypes in an In Vitro Pharmacodynamic Model Simulating Urine Concentrations Obtained after Oral Administration of a 400-Milligram Single Dose of Cefditoren-Pivoxil
    David Sevillano, Lorenzo Aguilar, Luis Alou, María-José Giménez, Martha Torrico, Natalia González, Fabio Cafini, María-Teresa Relaño, Pilar Coronel, José Prieto
  • Clinical Therapeutics
    Urinary Bactericidal Activity of Extended-Release Ciprofloxacin (1,000 Milligrams) versus Levofloxacin (500 Milligrams) in Healthy Volunteers Receiving a Single Oral Dose
    Florian M. E. Wagenlehner, Martina Kinzig-Schippers, Uwe Tischmeyer, Christine Wagenlehner, Fritz Sörgel, Kurt G. Naber
  • Pharmacology
    Urinary Excretion and Bactericidal Activities of Gemifloxacin and Ofloxacin after a Single Oral Dose in Healthy Volunteers
    Christoph K. Naber, Michaela Hammer, Martina Kinzig-Schippers, Christian Sauber, Fritz Sörgel, Elizabeth A. Bygate, Amanda J. Fairless, Konstanze Machka, Kurt G. Naber
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