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UTI

  • <em>In Vitro</em> and <em>In Vivo</em> Characterization of Tebipenem, an Oral Carbapenem
    Clinical Therapeutics
    In Vitro and In Vivo Characterization of Tebipenem, an Oral Carbapenem

    The continued evolution of bacterial resistance to the β-lactam class of antibiotics has necessitated countermeasures to ensure continued effectiveness in the treatment of infections caused by bacterial pathogens. One relatively successful approach has been the development of new β-lactam analogs with advantages over prior compounds in this class. The carbapenems are an example of such β-lactam analogs possessing improved stability...

    Nicole Cotroneo, Aileen Rubio, Ian A. Critchley, Chris Pillar, Michael J. Pucci
  • Antimicrobial Activity Evaluation of Tebipenem (SPR859), an Orally Available Carbapenem, against a Global Set of <span class="named-content genus-species" id="named-content-1">Enterobacteriaceae</span> Isolates, Including a Challenge Set of Organisms
    Susceptibility
    Antimicrobial Activity Evaluation of Tebipenem (SPR859), an Orally Available Carbapenem, against a Global Set of Enterobacteriaceae Isolates, Including a Challenge Set of Organisms

    The antimicrobial activity of tebipenem and other carbapenem agents were tested in vitro against a set of recent clinical isolates responsible for urinary tract infection (UTI), as well as against a challenge set. Isolates were tested by reference broth microdilution and included Escherichia coli (101 isolates),...

    S. J. Ryan Arends, Paul R. Rhomberg, Nicole Cotroneo, Aileen Rubio, Robert K. Flamm, Rodrigo E. Mendes
  • DS86760016, a Leucyl-tRNA Synthetase Inhibitor with Activity against <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span>
    Experimental Therapeutics
    DS86760016, a Leucyl-tRNA Synthetase Inhibitor with Activity against Pseudomonas aeruginosa

    DS86760016 is a new leucyl-tRNA-synthetase inhibitor at the preclinical development stage. DS86760016 showed potent activity against extended-spectrum multidrug-resistant Pseudomonas aeruginosa isolated from clinical samples and in vitro biofilms.

    Manoj Kumar, Madhvi Rao, Kedar P. Purnapatre, Tarani Kanta Barman, Vattan Joshi, Amuliya Kashyap, Tridib Chaira, Ramesh B. Bambal, Manisha Pandya, Souhaila Al Khodor, Dilip J. Upadhyay, Nobuhisa Masuda
  • Results from a Prospective <em>In Vitro</em> Study on the Mecillinam (Amdinocillin) Susceptibility of <em>Enterobacterales</em>
    Susceptibility
    Results from a Prospective In Vitro Study on the Mecillinam (Amdinocillin) Susceptibility of Enterobacterales

    The activity of mecillinam (amdinocillin) was assessed in Enterobacterales (n = 420) isolated from urine samples between 2016 and 2017. Mecillinam susceptibilities were 97.4% in Escherichia coli isolates (294/302), 89.7% in Klebsiella spp.

    Frieder Fuchs, Axel Hamprecht
  • Open Access
    Pharmacology
    Pharmacokinetics and Pharmacodynamics of Fosfomycin and Its Activity against Extended-Spectrum-β-Lactamase-, Plasmid-Mediated AmpC-, and Carbapenemase-Producing Escherichia coli in a Murine Urinary Tract Infection Model
    Ilya Nikolaevich Zykov, Ørjan Samuelsen, Lotte Jakobsen, Lars Småbrekke, Dan I. Andersson, Arnfinn Sundsfjord, Niels Frimodt-Møller
  • Mechanisms of Resistance
    Urinary Tract Conditions Affect Fosfomycin Activity against Escherichia coli Strains Harboring Chromosomal Mutations Involved in Fosfomycin Uptake
    G. Martín-Gutiérrez, F. Docobo-Pérez, J. Rodriguez-Beltrán, J. M. Rodríguez-Martínez, J. Aznar, A. Pascual, J. Blázquez
  • Mechanisms of Resistance
    Antibacterial Resistance in Ureaplasma Species and Mycoplasma hominis Isolates from Urine Cultures in College-Aged Females
    Marissa A. Valentine-King, Mary B. Brown
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