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vancomycin resistance

  • Oral Fosfomycin Treatment for Enterococcal Urinary Tract Infections in a Dynamic <em>In Vitro</em> Model
    Pharmacology
    Oral Fosfomycin Treatment for Enterococcal Urinary Tract Infections in a Dynamic In Vitro Model

    There are limited treatment options for enterococcal urinary tract infections, especially vancomycin-resistant Enterococcus (VRE). Oral fosfomycin is a potential option, although limited data are available guiding dosing and susceptibility. We undertook pharmacodynamic profiling of fosfomycin against E. faecalis and...

    Iain J. Abbott, Elke van Gorp, Aart van der Meijden, Rixt A. Wijma, Joseph Meletiadis, Jason A. Roberts, Johan W. Mouton, Anton Y. Peleg
  • Expansion of Vancomycin-Resistant <em>Enterococcus faecium</em> in an Academic Tertiary Hospital in Southwest Germany: a Large-Scale Whole-Genome-Based Outbreak Investigation
    Epidemiology and Surveillance
    Expansion of Vancomycin-Resistant Enterococcus faecium in an Academic Tertiary Hospital in Southwest Germany: a Large-Scale Whole-Genome-Based Outbreak Investigation

    Vancomycin-resistant Enterococcus faecium (VREfm) is a frequent cause of nosocomial outbreaks. In the second half of 2015, a sharp increase in the incidence of VREfm was observed at our university medical center.

    Jan Liese, Leonard Schüle, Philipp Oberhettinger, Leonie Tschörner, Tran Nguyen, Daniela Dörfel, Wichard Vogel, Matthias Marschal, Ingo Autenrieth, Matthias Willmann, Silke Peter
  • Epidemiology and Surveillance
    Identification of a Novel Genomic Island Associated with vanD-Type Vancomycin Resistance in Six Dutch Vancomycin-Resistant Enterococcus faecium Isolates
    Janetta Top, Jan C. Sinnige, Ellen C. Brouwer, Guido Werner, Jukka Corander, Juliëtte A. Severin, Rogier Jansen, E. Bathoorn, Marc J. M. Bonten, John W. A. Rossen, Rob J. L. Willems
  • Experimental Therapeutics
    Combination Antibiotic Exposure Selectively Alters the Development of Vancomycin Intermediate Resistance in Staphylococcus aureus
    Xuting Zheng, Andrew D. Berti, Sue McCrone, Melanie Roch, Adriana E. Rosato, Warren E. Rose, Baiyi Chen
  • Mechanisms of Resistance
    Metabolic Mitigation of Staphylococcus aureus Vancomycin Intermediate-Level Susceptibility
    Stewart G. Gardner, Darrell D. Marshall, Robert S. Daum, Robert Powers, Greg A. Somerville
  • Open Access
    Mechanisms of Resistance
    Prevalence of Slow-Growth Vancomycin Nonsusceptibility in Methicillin-Resistant Staphylococcus aureus
    Yuki Katayama, Takuya Azechi, Motoyasu Miyazaki, Tohru Takata, Miwa Sekine, Hidehito Matsui, Hideaki Hanaki, Koji Yahara, Hiroshi Sasano, Kota Asakura, Tomoiku Takaku, Tomonori Ochiai, Norio Komatsu, Henry F. Chambers
  • Pharmacology
    Comparative Pharmacodynamics of Single-Dose Oritavancin and Daily High-Dose Daptomycin Regimens against Vancomycin-Resistant Enterococcus faecium Isolates in an In Vitro Pharmacokinetic/Pharmacodynamic Model of Infection
    Adam Belley, David Lalonde-Séguin, Francis F. Arhin, Greg Moeck
  • Mechanisms of Resistance
    Influence of IS256 on Genome Variability and Formation of Small-Colony Variants in Staphylococcus aureus
    Franziska Kleinert, René Kallies, Michael Hort, Annegret Zweynert, Christiane Szekat, Michael Nagel, Gabriele Bierbaum
  • Clinical Therapeutics
    Effect of Continuous and Sequential Therapy among Veterans Receiving Daptomycin or Linezolid for Vancomycin-Resistant Enterococcus faecium Bacteremia
    Nicholas S. Britt, Emily M. Potter, Nimish Patel, Molly E. Steed
  • Biologic Response Modifiers
    VraR Binding to the Promoter Region of agr Inhibits Its Function in Vancomycin-Intermediate Staphylococcus aureus (VISA) and Heterogeneous VISA
    Yuanyuan Dai, Wenjiao Chang, Changcheng Zhao, Jing Peng, Liangfei Xu, Huaiwei Lu, Shusheng Zhou, Xiaoling Ma

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