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virtual screening

  • Promising New Antifungal Treatment Targeting Chorismate Synthase from <em>Paracoccidioides brasiliensis</em>
    Chemistry; Biosynthesis
    Promising New Antifungal Treatment Targeting Chorismate Synthase from Paracoccidioides brasiliensis

    Paracoccidioidomycosis (PCM), caused by Paracoccidioides, is a systemic mycosis with granulomatous character and a restricted therapeutic arsenal. The aim of this work was to search for new alternatives to treat largely neglected tropical mycosis, such as PCM.

    Franciele Abigail Vilugron Rodrigues-Vendramini, Cidnei Marschalk, Marina Toplak, Peter Macheroux, Patricia de Souza Bonfim-Mendonça, Terezinha Inez Estivalet Svidzinski, Flavio Augusto Vicente Seixas, Erika Seki Kioshima
  • Pharmacology
    Targeting the Homoserine Dehydrogenase of Paracoccidioides Species for Treatment of Systemic Fungal Infections
    Mariane C. Bagatin, Arethusa L. Pimentel, Débora C. Biavatti, Ernani A. Basso, Erika S. Kioshima, Flavio A. V. Seixas, Gisele de F. Gauze
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