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in vivo

  • The Added Value of Longitudinal Imaging for Preclinical <em>In Vivo</em> Efficacy Testing of Therapeutic Compounds against Cerebral Cryptococcosis
    Experimental Therapeutics
    The Added Value of Longitudinal Imaging for Preclinical In Vivo Efficacy Testing of Therapeutic Compounds against Cerebral Cryptococcosis

    Brain infections with Cryptococcus neoformans are associated with significant morbidity and mortality. Cryptococcosis typically presents as meningoencephalitis or fungal mass lesions called cryptococcomas. Despite frequent in vitro discoveries of promising novel antifungals, the clinical need for drugs that can more efficiently treat these brain infections...

    Liesbeth Vanherp, Jennifer Poelmans, Amy Hillen, Guilhem Janbon, Matthias Brock, Katrien Lagrou, Greetje Vande Velde, Uwe Himmelreich
  • Comparative <em>In Vivo</em> Antibacterial Activity of Human-Simulated Exposures of Cefiderocol and Ceftazidime against <em>Stenotrophomonas maltophilia</em> in the Murine Thigh Model
    Pharmacology
    Comparative In Vivo Antibacterial Activity of Human-Simulated Exposures of Cefiderocol and Ceftazidime against Stenotrophomonas maltophilia in the Murine Thigh Model

    Cefiderocol is a novel siderophore cephalosporin that utilizes bacterial ferric iron transports to cross the outer membrane. Cefiderocol shows high stability against all classes of β-lactamases, rendering it extremely potent against carbapenem- and multidrug-resistant Gram-negative organisms.

    Iris H. Chen, James M. Kidd, Kamilia Abdelraouf, David P. Nicolau
  • Open Access
    <em>In Vivo</em> Pharmacodynamic Study of Cefiderocol, a Novel Parenteral Siderophore Cephalosporin, in Murine Thigh and Lung Infection Models
    Experimental Therapeutics
    In Vivo Pharmacodynamic Study of Cefiderocol, a Novel Parenteral Siderophore Cephalosporin, in Murine Thigh and Lung Infection Models

    The pharmacokinetic (PK) and pharmacodynamic (PD) parameters which correlated with the in vivo efficacy of cefiderocol were evaluated using neutropenic murine thigh and lung infection models in which the infections were caused by a variety of Gram-negative bacilli.

    Rio Nakamura, Tsukasa Ito-Horiyama, Miki Takemura, Shinsuke Toba, Shuhei Matsumoto, Tatsuya Ikehara, Masakatsu Tsuji, Takafumi Sato, Yoshinori Yamano
  • <em>In Vitro</em> and <em>In Vivo</em> Activities of the Riminophenazine TBI-166 against <em>Mycobacterium tuberculosis</em>
    Experimental Therapeutics
    In Vitro and In Vivo Activities of the Riminophenazine TBI-166 against Mycobacterium tuberculosis

    The riminophenazine agent clofazimine (CFZ) is repurposed as an important component of the new short-course multidrug-resistant tuberculosis regimen and significantly shortens first-line regimen for drug-susceptible tuberculosis in mice. However, CFZ use is hampered by its unwelcome skin discoloration in patients.

    Jian Xu, Bin Wang, Lei Fu, Hui Zhu, Shaochen Guo, Haihong Huang, Dali Yin, Ye Zhang, Yu Lu
  • Evaluation of Carbapenems for Treatment of Multi- and Extensively Drug-Resistant <em>Mycobacterium tuberculosis</em>
    Pharmacology
    Evaluation of Carbapenems for Treatment of Multi- and Extensively Drug-Resistant Mycobacterium tuberculosis

    Multi- and extensively drug-resistant tuberculosis (M/XDR-TB) has become an increasing threat not only in countries where the TB burden is high but also in affluent regions, due to increased international travel and globalization. Carbapenems are earmarked as potentially active drugs for the treatment of Mycobacterium tuberculosis.

    Sander P. van Rijn, Marlanka A. Zuur, Richard Anthony, Bob Wilffert, Richard van Altena, Onno W. Akkerman, Wiel C. M. de Lange, Tjip S. van der Werf, Jos G. W. Kosterink, Jan-Willem C. Alffenaar
  • Implications of the EUCAST Trailing Phenomenon in <span class="named-content genus-species" id="named-content-1">Candida tropicalis</span> for the <em>In Vivo</em> Susceptibility in Invertebrate and Murine Models
    Susceptibility
    Implications of the EUCAST Trailing Phenomenon in Candida tropicalis for the In Vivo Susceptibility in Invertebrate and Murine Models

    Candida tropicalis isolates often display reduced but persistent growth (trailing) over a broad fluconazole concentration range during EUCAST susceptibility testing. Whereas weak trailing (<25% of the positive growth control) is common and found not to impair fluconazole efficacy, we investigated if more pronounced trailing impacted treatment efficacy.

    ...
    K. M. T. Astvad, D. Sanglard, E. Delarze, R. K. Hare, M. C. Arendrup
  • Immunosuppressed Adult Zebrafish Model of Mucormycosis
    Letter to the Editor
    Immunosuppressed Adult Zebrafish Model of Mucormycosis
    A. M. Tatara, S. Wurster, C. R. Lockworth, N. D. Albert, T. J. Walsh, A. G. Mikos, G. T. Eisenhoffer, D. P. Kontoyiannis
  • Antiviral Agents
    High Dose and Delayed Treatment with Bile Acids Ineffective in RML Prion-Infected Mice
    Grant Norman, Jody Campeau, Valerie L. Sim
  • Open Access
    Pharmacology
    Pharmacokinetics and Pharmacodynamics of Fosfomycin and Its Activity against Extended-Spectrum-β-Lactamase-, Plasmid-Mediated AmpC-, and Carbapenemase-Producing Escherichia coli in a Murine Urinary Tract Infection Model
    Ilya Nikolaevich Zykov, Ørjan Samuelsen, Lotte Jakobsen, Lars Småbrekke, Dan I. Andersson, Arnfinn Sundsfjord, Niels Frimodt-Møller
  • Experimental Therapeutics
    In Vitro, In Silico, and In Vivo Analyses of Novel Aromatic Amidines against Trypanosoma cruzi
    Camila C. Santos, Jéssica R. Lionel, Raiza B. Peres, Marcos M. Batista, Patrícia B. da Silva, Gabriel M. de Oliveira, Cristiane F. da Silva, Denise G. J. Batista, Sandra Maria O. Souza, Carolina H. Andrade, Bruno J. Neves, Rodolpho C. Braga, Donald A. Patrick, Svetlana M. Bakunova, Richard R. Tidwell, Maria de Nazaré C. Soeiro

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