WCK 5153

Mechanisms of Action: Physiological Effects
In Vitro and In Vivo Activities of β-Lactams in Combination with the Novel β-Lactam Enhancers Zidebactam and WCK 5153 against Multidrug-Resistant Metallo-β-Lactamase-Producing Klebsiella pneumoniae
Zidebactam and WCK 5153 are novel bicyclo-acyl hydrazide (BCH) agents that have previously been shown to act as β-lactam enhancer (BLE) antibiotics in Pseudomonas aeruginosa and Acinetobacter baumannii. The objectives of this work were to identify the molecular targets of these BCHs in...

Bartolome Moya, Isabel M. Barcelo, Gabriel Cabot, Gabriel Torrens, Snehal Palwe, Prashant Joshi, Kushal Umarkar, Swapna Takalkar, Hariharan Periasamy, Sachin Bhagwat, Mahesh Patel, German Bou, Antonio Oliver
Mechanisms of Action: Physiological Effects
Potent β-Lactam Enhancer Activity of Zidebactam and WCK 5153 against Acinetobacter baumannii, Including Carbapenemase-Producing Clinical Isolates
Bartolome Moya, Isabel M. Barcelo, Sachin Bhagwat, Mahesh Patel, German Bou, Krisztina M. Papp-Wallace, Robert A. Bonomo, Antonio Oliver
Mechanisms of Action: Physiological Effects
WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent “β-Lactam Enhancer” Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones
Bartolome Moya, Isabel M. Barcelo, Sachin Bhagwat, Mahesh Patel, German Bou, Krisztina M. Papp-Wallace, Robert A. Bonomo, Antonio Oliver

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