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zebrafish

  • Rifabutin Is Bactericidal against Intracellular and Extracellular Forms of <span class="named-content genus-species" id="named-content-1">Mycobacterium abscessus</span>
    Mechanisms of Action: Physiological Effects
    Rifabutin Is Bactericidal against Intracellular and Extracellular Forms of Mycobacterium abscessus

    Mycobacterium abscessus is increasingly recognized as an emerging opportunistic pathogen causing severe lung diseases. As it is intrinsically resistant to most conventional antibiotics, there is an unmet medical need for effective treatments. Repurposing of clinically validated pharmaceuticals represents an attractive option for the development of chemotherapeutic...

    Matt D. Johansen, Wassim Daher, Françoise Roquet-Banères, Clément Raynaud, Matthéo Alcaraz, Florian P. Maurer, Laurent Kremer
  • Zebrafish Embryo Model for Assessment of Drug Efficacy on Mycobacterial Persisters
    Experimental Therapeutics
    Zebrafish Embryo Model for Assessment of Drug Efficacy on Mycobacterial Persisters

    Tuberculosis continues to kill millions of people each year. The main difficulty in eradication of the disease is the prolonged duration of treatment, which takes at least 6 months. Persister cells have long been associated with failed treatment and disease relapse because of their phenotypical, though transient, tolerance to drugs. By targeting these persisters, the duration of treatment could be shortened, leading to improved...

    Susanna Commandeur, Nino Iakobachvili, Marion Sparrius, Mariam Mohamed Nur, Galina V. Mukamolova, Wilbert Bitter
  • Dissecting <em>erm</em>(41)-Mediated Macrolide-Inducible Resistance in <span class="named-content genus-species" id="named-content-1">Mycobacterium abscessus</span>
    Mechanisms of Resistance
    Dissecting erm(41)-Mediated Macrolide-Inducible Resistance in Mycobacterium abscessus

    Macrolides are the cornerstone of Mycobacterium abscessus multidrug therapy, despite that most patients respond poorly to this class of antibiotics due to the inducible resistance phenotype that occurs during drug treatment. This mechanism is driven by the macrolide-inducible ribosomal methylase encoded by erm(41), whose expression is activated by the...

    Matthias Richard, Ana Victoria Gutiérrez, Laurent Kremer
  • Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish
    Pharmacology
    Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish

    Isoniazid (INH) is a first-line antituberculosis drug. The incidence of adverse reactions accompanied by inflammation in the liver during drug administration to tuberculosis patients is high and severely affects clinical treatment.

    Yun Zhang, Juan Cen, Zhili Jia, Chung-Der Hsiao, Qing Xia, Xue Wang, Xiqiang Chen, Rongchun Wang, Zhenzhou Jiang, Luyong Zhang, Kechun Liu
  • Immunosuppressed Adult Zebrafish Model of Mucormycosis
    Letter to the Editor
    Immunosuppressed Adult Zebrafish Model of Mucormycosis
    A. M. Tatara, S. Wurster, C. R. Lockworth, N. D. Albert, T. J. Walsh, A. G. Mikos, G. T. Eisenhoffer, D. P. Kontoyiannis
  • Mechanisms of Resistance
    Bedaquiline Inhibits the ATP Synthase in Mycobacterium abscessus and Is Effective in Infected Zebrafish
    Christian Dupont, Albertus Viljoen, Sangeeta Thomas, Françoise Roquet-Banères, Jean-Louis Herrmann, Kevin Pethe, Laurent Kremer
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